TH76950A - Phathalazine derivative for PARP inhibitors - Google Patents
Phathalazine derivative for PARP inhibitorsInfo
- Publication number
- TH76950A TH76950A TH501002995A TH0501002995A TH76950A TH 76950 A TH76950 A TH 76950A TH 501002995 A TH501002995 A TH 501002995A TH 0501002995 A TH0501002995 A TH 0501002995A TH 76950 A TH76950 A TH 76950A
- Authority
- TH
- Thailand
- Prior art keywords
- phathalazine
- derivative
- formula
- parp inhibitors
- substance
- Prior art date
Links
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 239000000126 substance Substances 0.000 claims abstract 7
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 101700007241 APOC4 Proteins 0.000 abstract 2
- 101710038729 F2R Proteins 0.000 abstract 2
- 101700036247 PARP1 Proteins 0.000 abstract 2
- 102100014579 PARP1 Human genes 0.000 abstract 2
- 101700053624 PARP2 Proteins 0.000 abstract 2
- 101700027237 PROA Proteins 0.000 abstract 2
- 101700004528 arp Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
Abstract
DC60 (26/09/48) การประดิษฐ์นี้ให้สารประกอบตามสูตร (I), การใช้สารนี้เป็นสารยับยั้ง PARP และสารผสม ทางเภสัชกรรม ซึ่งประกอบรวมด้วยสารประกอบตามสูตร (I) ดังกล่าว (สูตรเคมี) (I) ซึ่ง R1, R2, L1, L2, X, Y, Q และ Z มีความหมายตามที่กำหนด การประดิษฐ์นี้ให้สารประกอบตามสูตร (I), การใช้สารนี้เป็นสารยับยั้ง PARP และสารผสม ทางเภสัชกรรม ซึ่งประกอบรวมด้วยสารประกอบตามสูตร (I) ดังกล่าว (สูตรเคมี) (I) ซึ่ง R1, R2, L1, L2, X, Y, Q และZ มีความหมายตามที่กำหนด สิทธิบัตรยา DC60 (26/09/48) This invention provides a compound according to formula (I), the use of this substance as a PARP inhibitor and a pharmaceutical mixtures comprising such (I) compounds (chemical formula) (I). Where R1, R2, L1, L2, X, Y, Q and Z have the given meanings. The invention provides a compound according to the formula (I), the use of this substance as a PARP inhibitor and a pharmaceutical mixtures comprising such (I) compounds (chemical formulas) (I) which R1, R2, L1, L2. , X, Y, Q, and Z have the meanings defined by the drug patent.
Claims (1)
Publications (1)
Publication Number | Publication Date |
---|---|
TH76950A true TH76950A (en) | 2006-04-05 |
Family
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