TH76289A - Amorphous Calcium Atorvastatin Process - Google Patents

Amorphous Calcium Atorvastatin Process

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Publication number
TH76289A
TH76289A TH501001166A TH0501001166A TH76289A TH 76289 A TH76289 A TH 76289A TH 501001166 A TH501001166 A TH 501001166A TH 0501001166 A TH0501001166 A TH 0501001166A TH 76289 A TH76289 A TH 76289A
Authority
TH
Thailand
Prior art keywords
amorphous calcium
calcium atorvastatin
phenyl
atorvastatin
dimethylethyl
Prior art date
Application number
TH501001166A
Other languages
Thai (th)
Inventor
คูมาร์ ยาเทนดรา
มาธาวะ ดิลีพ คูมาร์ ซาริดิ
สัตยนารายานะ สวาร์กัม
Original Assignee
นางอรทัย ธรรมเกษร
Filing date
Publication date
Application filed by นางอรทัย ธรรมเกษร filed Critical นางอรทัย ธรรมเกษร
Publication of TH76289A publication Critical patent/TH76289A/en

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Abstract

DC60 (22/04/48) กระบวนการผลิตอะทอร์วาสเตตินแคลเซียมแบบอสัณฐาน และอะทอร์วาสเตติน แคลเซียม แบบอสัณฐานที่ถูกทำให้เสถียรจะถูกจัดให้มีขึ้น กระบวนการผลิตอะทอร์วาสเตตินแคลเซียมแบบอสัณฐาน และอะทอร์วาสเตติน แคลเซียม แบบอสัณฐานที่ถูกทำให้เสถียรจะถูกจัดให้มีขึ้น สิทธิบัตรยา DC60 (22/04/48) Amorphous Calcium Atorvastatin Process And stabilized amorphous calcium atorvastatin is provided. Amorphous calcium atorvastatin production process And stabilized amorphous calcium atorvastatin will be provided.

Claims (1)

1. กระบวนการผลิตอะทอร์วาสเตตินแคลเซียมในรูปแบบอสัณฐาน ซึ่ง ประกอบด้วย a) การทำปฎิกิริยาสารละลาย (4R-ซิส)-1,1- ไดเมธิลเอธิล-6-{2-[2-(4-ฟลูออโรเฟ นิล)-5- (1-เมธิลเอธิล)-3-เฟนิล-4-[(เฟนิลอะมิโน)- คาร์บอนิล]-1H-พีรอล-1อิล]เอธิล}-2,2- ไดเมธิล-1,3-ไดออกเซน-4-อะซีเตต (สาร ประกอบ H ดังแสดงในแผนภูมิ l) ในตัวทำ ละลายที่ละลายในน้ำได้ซึ่งมีกรดเพื่อได้รับ [R-(R*,R*)]-1,1-ไดเมธิลเอธิล-2-(4-ฟลูออโร เฟนิล)-เบตา, เดลตา-ไดไฮดรอกซี-5-(1-เมธิลเอธิล)-3- เฟนิล-4-[(เฟนิลอะมิโน)คาร์บอนิล]-1H-พี รแท็ก : สิทธิบัตรยา1. The production process of amorphous calcium atorvastatin consists of a) solution reaction. (4R-cis) -1,1-dimethylethyl-6- (2- (2- (4- fluorophenyl) -5- (1- methyl ethyl)) -3-phenyl-4 - ((phenylamino) -carbonyl] -1H-perol-1il] ethyl) -2,2-dimethyl -1,3 - dioxane-4-acetate (H compound as shown in l chart) in aqueous solvent containing acid to obtain [R- (R *, R *)] - 1,1- dimethylethyl-2- (4-fluorophenyl) -beta, delta-dihydroxy-5 - (1-methyl ethyl) -3-phenyl-4 - ((phenyl amino) carbonyl] -1H-pretak: drug patent
TH501001166A 2005-03-17 Amorphous Calcium Atorvastatin Process TH76289A (en)

Publications (1)

Publication Number Publication Date
TH76289A true TH76289A (en) 2006-03-09

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