CA2522899A1 - Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) - Google Patents

Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) Download PDF

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Publication number
CA2522899A1
CA2522899A1 CA002522899A CA2522899A CA2522899A1 CA 2522899 A1 CA2522899 A1 CA 2522899A1 CA 002522899 A CA002522899 A CA 002522899A CA 2522899 A CA2522899 A CA 2522899A CA 2522899 A1 CA2522899 A1 CA 2522899A1
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Canada
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
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CA002522899A
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French (fr)
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CA2522899C (en
Inventor
Stephen Robert Byrn
David Andrew Coates
Karen Sue Gushurst
Henry Grant Ii Morrison
Aeri Park
Petinka Ivanova Vlahova
Zheng Jane Li
Joseph Francis Krzyzaniak
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Warner Lambert Co LLC
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Individual
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Priority claimed from CA002450111A external-priority patent/CA2450111C/en
Publication of CA2522899A1 publication Critical patent/CA2522899A1/en
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Publication of CA2522899C publication Critical patent/CA2522899C/en
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  • Pyrrole Compounds (AREA)

Abstract

Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-(.beta., .DELTA.;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt atorvastatin designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
CA002522899A 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) Expired - Fee Related CA2522899C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30204901P 2001-06-29 2001-06-29
US60/302,049 2001-06-29
CA002450111A CA2450111C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002450111A Division CA2450111C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Publications (2)

Publication Number Publication Date
CA2522899A1 true CA2522899A1 (en) 2003-01-16
CA2522899C CA2522899C (en) 2006-04-25

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ID=35452260

Family Applications (14)

Application Number Title Priority Date Filing Date
CA002521933A Expired - Fee Related CA2521933C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521792A Expired - Fee Related CA2521792C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521833A Expired - Fee Related CA2521833C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521956A Expired - Fee Related CA2521956C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1-h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521887A Expired - Fee Related CA2521887C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521980A Expired - Fee Related CA2521980C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521891A Expired - Fee Related CA2521891C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521953A Expired - Fee Related CA2521953C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521828A Expired - Fee Related CA2521828C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521958A Expired - Fee Related CA2521958C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-pheyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521908A Expired - Fee Related CA2521908C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002522899A Expired - Fee Related CA2522899C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521993A Abandoned CA2521993A1 (en) 2001-06-29 2002-05-21 Crystalline forms of ¬r-(r*,r*)|-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino)carbonyl|-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521776A Expired - Fee Related CA2521776C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Family Applications Before (11)

Application Number Title Priority Date Filing Date
CA002521933A Expired - Fee Related CA2521933C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521792A Expired - Fee Related CA2521792C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521833A Expired - Fee Related CA2521833C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521956A Expired - Fee Related CA2521956C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1-h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521887A Expired - Fee Related CA2521887C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521980A Expired - Fee Related CA2521980C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521891A Expired - Fee Related CA2521891C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521953A Expired - Fee Related CA2521953C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521828A Expired - Fee Related CA2521828C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521958A Expired - Fee Related CA2521958C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-pheyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521908A Expired - Fee Related CA2521908C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA002521993A Abandoned CA2521993A1 (en) 2001-06-29 2002-05-21 Crystalline forms of ¬r-(r*,r*)|-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino)carbonyl|-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521776A Expired - Fee Related CA2521776C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Country Status (1)

Country Link
CA (14) CA2521933C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8080672B2 (en) 2005-12-13 2011-12-20 Teva Pharmaceutical Industries Ltd. Crystal form of atorvastatin hemi-calcium and processes for preparation thereof

Also Published As

Publication number Publication date
CA2521887A1 (en) 2003-01-16
CA2521956A1 (en) 2003-01-16
CA2521887C (en) 2006-04-25
CA2521953C (en) 2006-03-14
CA2521833C (en) 2006-04-25
CA2521776C (en) 2006-04-25
CA2521828A1 (en) 2003-01-16
CA2521833A1 (en) 2003-01-16
CA2521891C (en) 2006-04-25
CA2521993A1 (en) 2003-01-16
CA2521958A1 (en) 2003-01-16
CA2521953A1 (en) 2003-01-16
CA2521980C (en) 2006-08-29
CA2521891A1 (en) 2003-01-16
CA2521792C (en) 2006-04-25
CA2521908A1 (en) 2003-01-16
CA2521792A1 (en) 2003-01-16
CA2521776A1 (en) 2003-01-16
CA2521933C (en) 2006-03-21
CA2521828C (en) 2006-04-25
CA2521980A1 (en) 2003-01-16
CA2521958C (en) 2006-08-29
CA2521956C (en) 2006-04-25
CA2521933A1 (en) 2003-01-16
CA2521908C (en) 2006-04-25
CA2522899C (en) 2006-04-25

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