CA2521980A1 - Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) - Google Patents

Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) Download PDF

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Publication number
CA2521980A1
CA2521980A1 CA002521980A CA2521980A CA2521980A1 CA 2521980 A1 CA2521980 A1 CA 2521980A1 CA 002521980 A CA002521980 A CA 002521980A CA 2521980 A CA2521980 A CA 2521980A CA 2521980 A1 CA2521980 A1 CA 2521980A1
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CA
Canada
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
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CA002521980A
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French (fr)
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CA2521980C (en
Inventor
Stephen Robert Byrn
Karen Sue Gushurst
Henry Grant Ii Morrison
Aeri Park
Petinka Ivanova Vlahova
Zheng Jane Li
Joseph Francis Krzyzaniak
David Andrew Coates
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Warner Lambert Co LLC
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Individual
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Publication date
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Application filed by Individual filed Critical Individual
Priority claimed from CA002450111A external-priority patent/CA2450111C/en
Publication of CA2521980A1 publication Critical patent/CA2521980A1/en
Application granted granted Critical
Publication of CA2521980C publication Critical patent/CA2521980C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta., .DELTA.;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt atorvastatin designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
CA002521980A 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) Expired - Fee Related CA2521980C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30204901P 2001-06-29 2001-06-29
US60/302,049 2001-06-29
CA002450111A CA2450111C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002450111A Division CA2450111C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Publications (2)

Publication Number Publication Date
CA2521980A1 true CA2521980A1 (en) 2003-01-16
CA2521980C CA2521980C (en) 2006-08-29

Family

ID=35452260

Family Applications (14)

Application Number Title Priority Date Filing Date
CA002521891A Expired - Fee Related CA2521891C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002522899A Expired - Fee Related CA2522899C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521953A Expired - Fee Related CA2521953C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521908A Expired - Fee Related CA2521908C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521958A Expired - Fee Related CA2521958C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-pheyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521792A Expired - Fee Related CA2521792C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521933A Expired - Fee Related CA2521933C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521993A Abandoned CA2521993A1 (en) 2001-06-29 2002-05-21 Crystalline forms of ¬r-(r*,r*)|-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino)carbonyl|-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521980A Expired - Fee Related CA2521980C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521828A Expired - Fee Related CA2521828C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521776A Expired - Fee Related CA2521776C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521956A Expired - Fee Related CA2521956C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1-h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521833A Expired - Fee Related CA2521833C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521887A Expired - Fee Related CA2521887C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Family Applications Before (8)

Application Number Title Priority Date Filing Date
CA002521891A Expired - Fee Related CA2521891C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002522899A Expired - Fee Related CA2522899C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521953A Expired - Fee Related CA2521953C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521908A Expired - Fee Related CA2521908C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521958A Expired - Fee Related CA2521958C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-pheyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521792A Expired - Fee Related CA2521792C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521933A Expired - Fee Related CA2521933C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521993A Abandoned CA2521993A1 (en) 2001-06-29 2002-05-21 Crystalline forms of ¬r-(r*,r*)|-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino)carbonyl|-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)

Family Applications After (5)

Application Number Title Priority Date Filing Date
CA002521828A Expired - Fee Related CA2521828C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521776A Expired - Fee Related CA2521776C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521956A Expired - Fee Related CA2521956C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1-h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521833A Expired - Fee Related CA2521833C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
CA002521887A Expired - Fee Related CA2521887C (en) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Country Status (1)

Country Link
CA (14) CA2521891C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0610344A2 (en) 2005-12-13 2016-11-29 Teva Pharma crystallized form of atorvastatin hemi-calcium, process for its preparation, derived pharmaceutical product and its medicinal use

Also Published As

Publication number Publication date
CA2521833A1 (en) 2003-01-16
CA2521887A1 (en) 2003-01-16
CA2521828A1 (en) 2003-01-16
CA2521993A1 (en) 2003-01-16
CA2521956C (en) 2006-04-25
CA2521953C (en) 2006-03-14
CA2521958C (en) 2006-08-29
CA2521887C (en) 2006-04-25
CA2521953A1 (en) 2003-01-16
CA2521776A1 (en) 2003-01-16
CA2521908A1 (en) 2003-01-16
CA2522899A1 (en) 2003-01-16
CA2521891C (en) 2006-04-25
CA2521792A1 (en) 2003-01-16
CA2521908C (en) 2006-04-25
CA2521956A1 (en) 2003-01-16
CA2522899C (en) 2006-04-25
CA2521776C (en) 2006-04-25
CA2521980C (en) 2006-08-29
CA2521933C (en) 2006-03-21
CA2521828C (en) 2006-04-25
CA2521833C (en) 2006-04-25
CA2521891A1 (en) 2003-01-16
CA2521933A1 (en) 2003-01-16
CA2521792C (en) 2006-04-25
CA2521958A1 (en) 2003-01-16

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