TH6649A - Plasminogen activation of the substance - Google Patents
Plasminogen activation of the substanceInfo
- Publication number
- TH6649A TH6649A TH8801000750A TH8801000750A TH6649A TH 6649 A TH6649 A TH 6649A TH 8801000750 A TH8801000750 A TH 8801000750A TH 8801000750 A TH8801000750 A TH 8801000750A TH 6649 A TH6649 A TH 6649A
- Authority
- TH
- Thailand
- Prior art keywords
- substance
- compounds
- plasminogen activation
- genetic
- gasgas
- Prior art date
Links
- 230000033885 plasminogen activation Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 claims 2
- 102000013566 Plasminogen Human genes 0.000 claims 1
- 108010051456 Plasminogen Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 230000010005 growth-factor like effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับวิธีสำหรับการผลิตสารปลุกฤทธิ์พลาสมิโนเจนชนิดที่ถูกไกลโคซิเลต (glycosylate) (ในที่นี้ได้รับการอ้างถึงภายใต้ชื่อว่า GASGAs) ซึ่งเป็นสารประกอบที่ได้จากสายเดี่ยวของเอนไซม์ ยูโรไคเนส (urokinase) (scuPA) ที่มีโดเมนคล้ายแฟคเตอร์เจริญ (GFD) เปลี่ยนแปลงไป สารประกอบในการดิษฐ์เหล่านี้นิยมเตรียมโดยวิธีพันธ์วิศวกรรมของ ดีเอ็นเอ ถอดรหัส uPA และทำให้ได้คุณสมบัติทางเภสัชของสารเหล่านี้ดีขึ้นกว่าเดิม สิทธิบัตรยา The invention relates to a method for producing glycosylated plasminogen activators. (glycosylate) (hereinafter referred to as GASGAs), a single-chain compound derived from the urokinase (scuPA) enzyme with the growth factor-like domain (GFD). These compounds are commonly prepared using genetic genetic engineering, uPA transcription, and the pharmacological properties of these compounds are improved.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH6649A true TH6649A (en) | 1989-10-02 |
Family
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