TH5164C3 - - Google Patents

Abstract

DC60 This invention focuses on a newly developed method of preparation of longan seed extract, which includes the extraction of dried longan seeds that have been ground into powder. Solvent selected from a mixture of propylene glycol (PG) and water in a ratio of 10-40% of PG 60-90% of water, with a ratio for extraction of dried longan kernels. : Solvent is 1: 2-10 weight per volume. According to the longan seed extract preparation method of this invention, the appropriate solvent and the appropriate ratio were used. As a result, the seed extract Longan prepared from this invention process contains three polyphenols: gallic acid, ellagic acid and kori. Lagin (corilagin) in higher doses And the extract can be stored for a longer time, which the extract obtained this can be mixed in the preparation. A wide variety of body products, especially those used to inhibit fungi, yeast and bacteria, the invention aims at the newly developed process of preparing longan seed extract. The dried longan seeds were also extracted into powder. Solvent selected from a mixture of propylene glycol (PG) and water at a ratio of 10-40% of PG: 60-90% of water with a ratio for extraction of dried longan seeds. Crushed: Solvent is 1: 2-10 weight per volume. According to the longan seed extract preparation method of this invention, the appropriate solvent and the appropriate ratio were used. As a fruit to extract the seeds Longan prepared from this invention process contains three polyphenols: gallic acid, ellagic acid and kori. Lagin (corilagin) in higher doses And the extract can be stored for a longer time, which the extract obtained this can be mixed in the preparation. Products applicable to the body, especially products used to inhibit mold, yeast and bacteria: drug patent.

Claims (9)

1. Method for preparation of longan seed extract that included steps of a) Preparation of dried longan seeds to be powdered b) Extraction of dried longan seeds to powder with a solvent selected from the mix Of propylene glycol (PG) and water in a ratio of 10-40% of PG: 60-90% of water, with the ratio for extraction of crushed dried longan kernels: solvent is 1: 2. -10 weight per volume c) separation of liquid and residue by centrifugation and filtration d) removal of residue from the process C) re-extraction following extraction of step b) and separation according to step c) e) collection of all the resulting liquid extracts. 2. Process according to claim 1, which includes further PG evaporation process to obtain concentrated extracts. 3. Process according to Clause 1, which includes the process of Adding a binder selected from lactose And maltodetin in the amount of 1-3% w / v of the extract in the extract from the step e), and spray drying at 180 / 85-95 ํ. (In / out) to obtain a dry powder extract 4. Method according to claim 1, where the ratio for extraction of dried longan kernels: solvent is 1:10 weight per volume. 5. Process according to claim 1, whereby longan seeds are longan seeds from selected strains from Edo, pink, green and black leaves. 6. Process according to claim 2 or 3, in which the aqueous extracted concentrate contains Selected key from chorilagin between 2-10 mg / g, gallic acid 3-8 mg / g, or ellagic acid 1.5-6 mg / g. Grams or combinations of that substance And that the dry powder extract contains the selected active substance from chorilagin between 0.01-5 mg / g, gallic acid 0.005-5 mg / g or Ella. Gic acid 0.01-3 mg / g or a mixture of that substance 7. Composition of longan seed extract obtained from the process of Clause 1-6, any one And pharmaceuticals acceptable carriers, additives, solvents or drug additives 8. Composition according to claim 7, which consists of longan seed extract Concentrate obtained from the process of claim No. 2 in the proportion of 1-30% by weight or seed extract. Longan powder obtained from the process of claim No. 3 in the proportion of 1-20% by weight. 9. Use of the elements according to claim 7 or 8 in the preparation of drugs or products for Use on the body for the treatment or relief of disease related to bacteria, fungi or yeast. Which diseases Is a disease associated with Crytococcus neoformans that causes pathologies in the brain and cortex. Especially in patients infected with HIV and Candida sp p. That caused oral or vaginal infection 1 0. Use in accordance with Clause 9 in which the product for use on the body is in a form of choice from The group includes soaps, liquid soaps, shampoos, vaginal wash, mouthwash, wound wash, gel or paste (paste) for mouth ulcers, dental effervescent granules, antifungal creams. Indoor cloth, oral film or candy and toothpaste