TH3902A - The process for the preparation of 5-chloro and 5-bromo-2-hydroxy nicotinic acid - Google Patents
The process for the preparation of 5-chloro and 5-bromo-2-hydroxy nicotinic acidInfo
- Publication number
- TH3902A TH3902A TH8601000547A TH8601000547A TH3902A TH 3902 A TH3902 A TH 3902A TH 8601000547 A TH8601000547 A TH 8601000547A TH 8601000547 A TH8601000547 A TH 8601000547A TH 3902 A TH3902 A TH 3902A
- Authority
- TH
- Thailand
- Prior art keywords
- molecular weight
- low molecular
- acid
- nicotinic acid
- chlorine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- GYXOTADLHQJPIP-UHFFFAOYSA-N 5-bromo-2-oxo-1h-pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC(Br)=CNC1=O GYXOTADLHQJPIP-UHFFFAOYSA-N 0.000 title 1
- CVICEEPAFUYBJG-UHFFFAOYSA-N 5-chloro-2,2-difluoro-1,3-benzodioxole Chemical group C1=C(Cl)C=C2OC(F)(F)OC2=C1 CVICEEPAFUYBJG-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 4
- 239000000460 chlorine Substances 0.000 claims abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052794 bromium Inorganic materials 0.000 claims abstract 3
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 3
- 239000011737 fluorine Substances 0.000 claims abstract 3
- UEYQJQVBUVAELZ-UHFFFAOYSA-N 2-Hydroxynicotinic acid Chemical compound OC(=O)C1=CC=CN=C1O UEYQJQVBUVAELZ-UHFFFAOYSA-N 0.000 claims abstract 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
Abstract
อัลคิลที่มีน้ำหนักโมเลกุลต่ำ, อัลคอกซีที่มีน้ำหนักโมเลกุลต่ำ คลอรีน, โบรมีน, ไอโอดีน หรือฟลูออรีน ซึ่งกระบวนการนี้ ประกอบ ด้วยการทำปฏิกิริยาการเติมฮาโลเจนให้แก่กรด 2-ไฮดรอกซีนิโค ติ นิคชนิดที่ตรงกันด้วยกรดไฮโปเฮลัสในกรดฮาโลเจนเข้มข้นหรือ กับไฮ โปเฮไลท์ของโลหะอัลคาไลในรูปสารละลายในน้ำหรือสารละลายใน น้ำที่ มีเบสผสมอยู่ด้วย สิทธิบัตรยา Low molecular weight alkyl, chlorine, bromine, iodine or fluorine low molecular weight alkyl, the process consists of an acid halogenation reaction. 2-hydroxy nicotinic acid, with hypochlorous acid, in concentrated halogen acid, or with hypochlorite of alkali metals in aqueous or aqueous solution form. There is a base mixed with a patent drug.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH3902A true TH3902A (en) | 1987-02-02 |
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