TH29600B - "Acepen and its homologous Preparation and use of these substances as pharmaceuticals " - Google Patents
"Acepen and its homologous Preparation and use of these substances as pharmaceuticals "Info
- Publication number
- TH29600B TH29600B TH9601002231A TH9601002231A TH29600B TH 29600 B TH29600 B TH 29600B TH 9601002231 A TH9601002231 A TH 9601002231A TH 9601002231 A TH9601002231 A TH 9601002231A TH 29600 B TH29600 B TH 29600B
- Authority
- TH
- Thailand
- Prior art keywords
- small
- phenyl
- replaced
- hydroxyl
- substances
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 4
- 239000003814 drug Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Abstract
สารประกอบสูตรทั่วไป ( สูตรเคมี ) I ที่ซึ่ง R1 เป็นฟินิลหรือแอลฟา-หรือมีตา-แนฟธิล ซึ่งเป็นหมู่ที่ซึ่งสามารถถูกแทนที่โดยไฮดรอกซิ อัลคิลขนาดเล็ก อัลคอกซิขนาดเล็ก อัลคอกซิขนาดเล็ก-คาร์บอนิล ฟินอกซิ แอซิลอกซิ ไฮดรอกซิ ฟีนอกซิ-ซัลโฟนิล ฮาโลเจน ไนโตร อะมิโน แอซิลอะมิโน หรือ N-อัลคิลขนาดเล็ก แอซิลอะมิโน R2 เป็นฟีนิล หรือฟีนิลที่ถูกแทนที่โดยไฮดรอกซิ หรือแอซิลอกซิ Y เป็นพันธะคาร์บอน-คาร์บอนหรือเป็นไวนิลีน; และ n เป็น 1,2 หรือ 3 และเกลือที่เกิดจากการเติมกรดที่ยอมรับทางยาของสารเหล่านี้เป็นสารยับยั้งโปรทีนไคเนส และ สามารถถูกใช้สำหรับการบำบัดการเป็นสื่อที่ผิดปกติโดยเอ็นไซม์เช่นนี้รวมถึงโรคที่เกี่ยวกับการ อักเสบ General formula compound (chemical formula) I, where R1 is phenyl, or alpha- or ta-naphthyl. Which is a group that can be replaced by hydroxyl Small alkyl Small alcoxin Small alkoxin - carbonylfoxyloxi, hydroxyphenoxin-sulfonyl, halogen, nitroaminoacylamino or N-Al. Small kyl, azylamino R2, is a phenyl or phenyl that has been replaced by hydroxyl. Or asyloxi Y, a carbon-carbon bond, or is vinilene; And n is 1,2 or 3, and the salts formed by the addition of a drug-tolerant acid of these substances are protene kinase inhibitors and can be used for the treatment of abnormal mediation by enzymes. This includes diseases related to inflammation.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH29600B true TH29600B (en) | 1998-08-14 |
Family
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