TH20342A - Pharmaceutical ingredients - Google Patents
Pharmaceutical ingredientsInfo
- Publication number
- TH20342A TH20342A TH9501002652A TH9501002652A TH20342A TH 20342 A TH20342 A TH 20342A TH 9501002652 A TH9501002652 A TH 9501002652A TH 9501002652 A TH9501002652 A TH 9501002652A TH 20342 A TH20342 A TH 20342A
- Authority
- TH
- Thailand
- Prior art keywords
- cyclosporin
- macrolide
- lower alkyl
- dimethyl isosorbide
- carrier media
- Prior art date
Links
- 239000004615 ingredient Substances 0.000 title claims abstract 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 claims abstract 3
- 108010036949 Cyclosporine Proteins 0.000 claims abstract 3
- 239000013543 active substance Substances 0.000 claims abstract 3
- 229960001265 ciclosporin Drugs 0.000 claims abstract 3
- 239000003120 macrolide antibiotic agent Substances 0.000 claims abstract 3
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 229930182912 cyclosporin Natural products 0.000 claims abstract 2
- 150000002148 esters Chemical class 0.000 claims abstract 2
- 239000004530 micro-emulsion Substances 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 229940041033 macrolides Drugs 0.000 abstract 1
Abstract
การประดิษฐ์นี้ทำให้มีไมโครอีมัลชัน พรีคอนเซนเทรท ที่ประกอบด้วยตัวกระทำออกฤทธิ์ที่ละลายยาก และสารตัวกลางพาหะ ที่ประกอบด้วย 1) วัฎภาคไฮโดรฟิลิค ซึ่งประกอบด้วยไดเมทิล ไอโซซอร์ไบด์ และ/หรือ โลเวอร์อัลคิล อัลตาโนอิค เอสเทอร์ 2) วัฎภาคลิโปฟิลิค และ 3) เซอร์แฟคแทนท์ ตัวกระทำออกฤทธิ์ อาจเป็นไซโคลสปอรินหรือมาโครไลด์ ในอีกลักษณะหนึ่งการ ประดิษฐ์นี้ทำให้มีส่วนผสมเภสัชภัณฑ์สำหรับใช้บริหารภายใน ลำไส้ หรือภายนอกลำไส้ทีป่ระกอบด้วยมาโครไลด์ อับเกรด สิทธิบัตรยา This invention has micro-emulsions. Preconcentrate Containing active agents that are difficult to dissolve And carrier media Consisting of 1) the hydrophilic cycle It consists of dimethyl isosorbide and / or lower alkyl altanoic esters, 2) lipophilic phase, and 3) serfactant. Active agent It could be cyclosporin or macrolide. On the other hand, the The invention makes it a pharmaceutical ingredient for intramuscular administration or outside the intestine containing patented drug-grade macrolides.
Claims (3)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH20342A true TH20342A (en) | 1996-09-03 |
Family
ID=
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