TH17756Y - Sugarcane wax nanoparticles for encapsulating active ingredients for transdermal delivery, and methods for preparing such particles. - Google Patents

Abstract

------July 26, 2019------(OCR) Page 1 of 1 Abstract of the Invention This invention concerns the development of a formulated sugarcane wax nanoparticle encapsulation for transdermal delivery. This nanoparticle is composed of sugarcane wax, liquid fat, active ingredient, surfactant, solvent, and water in optimal ratios that allow for a higher amount of sugarcane wax compared to conventional formulas. This results in improved stability and enhanced skin penetration. The resulting sugarcane wax nanoparticles have a particle size greater than 200 nanometers, exhibit good stability under accelerated conditions for over 4 months, and can encapsulate over 70% of the active ingredient. The preparation process of the sugarcane wax nanoparticles for transdermal delivery includes the steps of oil phase preparation, drug loading, aqueous phase preparation, and aqueous phase mixing. With the oil phase containing the active ingredient (homogenization) ------------ Page 1 of 1 page. Abstract of the Invention. This invention concerns the development of a formulated cane wax nanoparticle encapsulation for transdermal delivery. The nanoparticles consist of cane wax, liquid fat, active ingredient, surfactant, solvent, and water in optimal ratios that allow for a higher concentration of cane wax than conventional formulas. This results in improved stability and enhanced skin penetration. The resulting cane wax nanoparticles have a particle size less than 200 nm, exhibit good stability under accelerated conditions for over 4 months, and can encapsulate over 70% of the active ingredient. The preparation process for these cane wax nanoparticles for transdermal delivery includes the following steps: oil phase preparation, drug loading, aqueous phase preparation, and homogenization of the aqueous and oil phases containing the active ingredient.

Claims (10)

------July 26, 2019------(OCR) Page 1 of 2 pages. Claims 1. Cane wax nanoparticle composition for transdermal delivery consisting of: - Cane wax 0.1 - 6.0% by weight - Liquid fat 0.5 - 9.9% by weight - Active ingredient 0.025 - 5.0% by weight - Surfactant 3.0 - 10.0% by weight - Solvent 5.0 - 15.0% by weight - Water used to adjust volume to 100% by weight. 2. Cane wax nanoparticle composition for encapsulating active ingredients as per Claims 1 where the optimal weight ratio between cane wax and liquid fat is in the range of 2:8 to 6:4. 3. Cane wax nanoparticle composition for encapsulating active ingredients as per Claims 1 or 2 where the liquid fat can be selected from a group containing triglycerides. (Triglyceride), natural oil extract, or a mixture of such substances. 4. The composition of the sugarcane wax nanoparticles encapsulating the active ingredient according to patent claim 3, where the triglyceride can be selected from the group consisting of caprylic triglyceride, capric triglyceride, medium chain triglyceride, or a mixture of such substances. 5. The composition of the sugarcane wax nanoparticles encapsulating the active ingredient according to patent claim 3, where the natural oil extract can be selected from the group consisting of coconut oil, jojoba oil, lavender oil, or a mixture of such substances. 6. The composition of the sugarcane wax nanoparticles encapsulating the active ingredient according to patent claim 1, where the active ingredient is a flavonoid. 7. The composition of the sugarcane wax nanoparticles encapsulating the active ingredient according to patent claim 1, where the surfactant is... The encapsulated sugarcane wax nanoparticles, as per claim 1, may include a solvent of choice from a group consisting of sorbitan monolaurate, poloxamer, cetearyl alcohol (and) coco-glucoside, or a mixture of these substances. 8. The encapsulated sugarcane wax nanoparticles, as per claim 1, may also include a solvent of choice from a group consisting of polyoxyethylene, ethyl alcohol, isopropyl alcohol, or a mixture of these substances. 9. The encapsulated sugarcane wax nanoparticles, as per claim 1, may also include a moisturizing agent in the amount of 10.0 - 30.0 percent by weight; Select from the group containing glycerin, propylene glycol, or a mixture of these substances. Page 2 of 2 pages - Preservatives in the amount of 0.1 -1.0 percent by weight; select from the group containing phenoxyethanol, sodium benzoate, ethylhexylglyceride, methylpropanediol, phenylpropanol, caprylhydroxamic acid, or a mixture of these substances.10. Preparation method of sugarcane wax nanoparticles for encapsulating active ingredients for transdermal delivery according to one of the claims 1-9, which includes the following steps: - Preparation of the oil phase by dissolving sugarcane wax and liquid fat into a homogeneous mixture and adding a surfactant. Next, stir at a temperature of 70-80 degrees Celsius to obtain the oil phase mixture. Drug loading involves dissolving the active ingredient in a solvent until homogeneous, then mixing it with the oil phase to obtain the oil phase mixture containing the active ingredient. Aqueous phase preparation involves dissolving the surfactant soluble in the aqueous phase in water and stirring at 70-80 degrees Celsius until all ingredients are dissolved and homogeneous. This results in the aqueous phase mixture. Homogenization step involves pouring the aqueous phase solution into the hot oil phase mixture and stirring at 200-300 rpm until well combined. Then, stir again with a... High-speed centrifuges operate at speeds ranging from 8,000 to 50,000 rpm for 5-10 minutes, followed by particle size reduction using a high-pressure homogenizer. (High pressure homogenized ------------ Page 1 of 2 pages. Claims) 1. The composition of sugarcane wax nanoparticles encapsulating active ingredients for transdermal delivery consists of: - Sugarcane wax 0.1 - 6.0 percent by weight - Liquid fat 0.5 - 9.9 percent by weight - Active ingredient 0.025 - 5.0 percent by weight - Surfactant 3.0 - 10.0 percent by weight - Solvent 5.0 - 15.0 percent by weight - Water, used to adjust the volume to 100 percent by weight. 2. The nanoparticle composition of sugarcane wax encapsulates the active ingredient as per claim 1, where the optimal weight ratio between sugarcane wax and liquid fat is in the range of 2:8 to 6:4. 3. The nanoparticle composition of sugarcane wax encapsulating the active ingredient as per claim 1 or 2, where the liquid fat can be selected from a group containing triglycerides, natural oils, or a mixture of such ingredients. 4. The nanoparticle composition of sugarcane wax encapsulating the active ingredient, as per claim 3, where the triglyceride can be selected from a group consisting of caprylic triglyceride, capric triglyceride, medium-chain triglyceride, or a mixture of these. 5. The nanoparticle composition of sugarcane wax encapsulates the active ingredient as per claim 3, where the aforementioned natural oil extract can be selected from a group consisting of coconut oil, jojoba oil, lavender oil, or a mixture of these ingredients. 6. The sugarcane wax nanoparticle composition encapsulates the active ingredient as per claim 1, where the active ingredient is a flavonoid. 7. The composition of the sugarcane wax nanoparticles encapsulating the active ingredient, as per claim 1, whereby the surfactant can be selected from a group consisting of sorbitan monolaurate, poloxamer, cetearyl alcohol (and) coco-glucoside, or a mixture of these substances. (Page 2 of 2) 8. The sugarcane wax nanoparticle composition encapsulates the active ingredient as per claim 1, whereby the solvent can be selected from a group consisting of polyoxyethylene, ethyl alcohol, isopropyl alcohol, or a mixture of these substances. 9. The sugarcane wax nanoparticle composition encapsulating the active ingredients, as per claim 1, shall also include: - Moisturizing agents in the amount of 10.0 - 30.0 percent by weight; selectable from the group containing glycerin, propylene glycol, or a mixture of these substances. - Preservatives in the amount of 0.1 - 1.0 percent by weight; selectable from the group containing phenoxyethanol, sodium benzoate, ethylhexyglycerin, methylpropanediol, phenylpropanol, caprylhydroxamic acid, or a mixture of these substances. 10. Preparation method for sugarcane wax nanoparticles for transdermal delivery, according to one of Patents 1-9, which includes the following steps: - Oil phase preparation: Dissolving sugarcane wax and liquid fat until homogeneous, adding surfactant, and stirring at 70-80°C to obtain the oil phase mixture. - Drug loading: Dissolving the active ingredient in a dissolving agent until homogeneous, and then mixing it with the oil phase to obtain the oil phase mixture containing the active ingredient. - Aqueous phase preparation: Dissolving the surfactant dissolved in the aqueous phase in water and stirring at 70-80°C until all components are dissolved homogeneously to obtain the aqueous phase mixture. - Homogenization step: Mixing the aqueous phase mixture with the oil phase mixture containing the active ingredient by pouring the aqueous phase solution into the oil phase mixture while the solution is hot. Stir until well combined at a speed of 200-300 rpm. Then stir with a high-speed mixer at a speed of at least 8000 rpm for 5-10 minutes, and reduce the particle size using a high-pressure homogenizer.