TH1701007409A - Benzoxepin oxasolidinone compounds and methods of use - Google Patents
Benzoxepin oxasolidinone compounds and methods of useInfo
- Publication number
- TH1701007409A TH1701007409A TH1701007409A TH1701007409A TH1701007409A TH 1701007409 A TH1701007409 A TH 1701007409A TH 1701007409 A TH1701007409 A TH 1701007409A TH 1701007409 A TH1701007409 A TH 1701007409A TH 1701007409 A TH1701007409 A TH 1701007409A
- Authority
- TH
- Thailand
- Prior art keywords
- pi3k
- oxasolidinone
- benzoxepin
- compounds
- therapeutic agents
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 5
- LWZYUACNWRVDDJ-UHFFFAOYSA-N 1-benzoxepine Chemical compound O1C=CC=CC2=CC=CC=C12 LWZYUACNWRVDDJ-UHFFFAOYSA-N 0.000 title claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 5
- 102000030951 Phosphotransferases Human genes 0.000 claims abstract 2
- 108091000081 Phosphotransferases Proteins 0.000 claims abstract 2
- 230000002159 abnormal effect Effects 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 230000001404 mediated Effects 0.000 claims abstract 2
- 230000004048 modification Effects 0.000 claims abstract 2
- 238000006011 modification reaction Methods 0.000 claims abstract 2
- 230000000051 modifying Effects 0.000 claims abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims 1
Abstract
ชุดประกาศโฆษณา วันที่ 15 มีนาคม 2562 ที่บรรยายไว้ในที่นี้คือ สารประกอบเบนซ์ออกซะเซพินออกซะโซลิดิโนนที่มีแอกทิวิตีหรือ หน้าที่ในการดัดแปลงฟอสโฟอิโนซิไทด์-3 ไคเนส (PI3K) ซึ่งมีโครงสร้างสูตรโครงสร้าง I (โครงสร้างสูตรเคมี) I หรือสเตอรีโอไอโซเมอร์, เทาว์โทเมอร์, หรือเกลือที่ยอมรับได้ทางเภสัชกรรมของมัน, และ ที่มีตัวแทนที่และลักษณะทางโครงสร้างที่บรรยายไว้ในที่นี้ ที่ยังบรรยายไว้คือ องค์ประกอบทาง เภสัชกรรมและยารักษาโรคที่รวมสารประกอบสูตรโครงสร้าง I ตลอดจนวีธีของการใช้ตัวดัดเเปลง PI3K ดังกล่าว โดยลำพังและในการรวมกันกับสารบำบัดอื่น เพื่อการรักษามะเร็งหรือภาวะที่ถูกสื่อ หรือขึ้นอยู่กับการควบคุมผิดปกติของ PI3K: The March 15, 2019 announcement set described here is Benzoxepin oxasolidinone compounds with activity or Functional modification of phosphoocytide-3 kinase (PI3K) with structural formula I (structure chemical formula) I or stereosomer, thousandthomer. , Or its pharmacologically acceptable salt, and that has the agents and structural characteristics described herein What is also described is Path element Pharmaceutical and therapeutic agents combining the compound structural formula I as well as the method of using the aforementioned PI3K modulator alone and in combination with other therapeutic agents. For the treatment of cancer or mediated conditions Or depending on the abnormal control of PI3K:
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH1701007409A true TH1701007409A (en) | 2019-03-15 |
Family
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