TH1618A - The process of fabricating octa-peptides against wasopressins - Google Patents
The process of fabricating octa-peptides against wasopressinsInfo
- Publication number
- TH1618A TH1618A TH8401000053A TH8401000053A TH1618A TH 1618 A TH1618 A TH 1618A TH 8401000053 A TH8401000053 A TH 8401000053A TH 8401000053 A TH8401000053 A TH 8401000053A TH 1618 A TH1618 A TH 1618A
- Authority
- TH
- Thailand
- Prior art keywords
- beta
- phe
- wasopressins
- octa
- fabricating
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- SNDPXSYFESPGGJ-UHFFFAOYSA-N 2-aminopentanoic acid Chemical compound CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims 1
- SNDPXSYFESPGGJ-SCSAIBSYSA-N D-2-aminopentanoic acid Chemical group CCC[C@@H](N)C(O)=O SNDPXSYFESPGGJ-SCSAIBSYSA-N 0.000 claims 1
- -1 D-Chg Chemical compound 0.000 claims 1
- AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical group CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical group CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 claims 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims 1
- 125000001711 D-phenylalanine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000180 D-prolyl group Chemical group N1[C@@H](C(=O)*)CCC1 0.000 claims 1
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical group CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940124280 l-arginine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 2
- 108010004977 Vasopressins Proteins 0.000 abstract 2
- 102000002852 Vasopressins Human genes 0.000 abstract 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- 229960003726 vasopressin Drugs 0.000 abstract 2
- RMYPEYHEPIZYDJ-SNVBAGLBSA-N (2r)-2-azaniumyl-3-(4-ethoxyphenyl)propanoate Chemical compound CCOC1=CC=C(C[C@@H](N)C(O)=O)C=C1 RMYPEYHEPIZYDJ-SNVBAGLBSA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 125000004119 disulfanediyl group Chemical group *SS* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
Abstract
สารออคตาเพบไทด์ ซึ่งมีสูตรที่ประกอบด้วยเพบไทด์ 6หน่วยอยู่เป็นวงและมีหางเป็นไดเพบไทด์และไม่มีไกลซีนในตำแหน่ง ที่ 9 นี้พบว่ามีฤทธิ์รุนแรงในการต่อต้านฤทธิ์ของวาโซเพรสซิน โดยใช้ปฏิกิริยาการเกิดวงของได-เมอร์แคบเพื่อให้ได้วงไดไธโอ ชนิดที่สำคัญของสารประกอบในหมู่นี้คือ (1-(เบตา-เมอร์แคพโต- เบตา, เบตา-ไซโคลเพนตาเมธิลีนโพรพิออนิค แอซิด) -2-(O-เอธิล -D-ไทโรซีน)-4-แวลีน-8-อาร์จินีน-9-เดสไกลซีน) วาโซเพรสซิน Octapheptide Which has a formula containing peptides 6 in a loop and a dipeptide tail and no glycine in the ninth position were found to be highly potent against vasopressin. By using a narrow band diathermy reaction to obtain the dithio band. The major types of compounds among these are (1- (beta-mercapto-beta, beta-cyclopentamethylene propionic acid) -2- (O-ethyl-D-tyrosine ) -4-Valine-8-Arginine-9-Dessglycine) Vasopressin
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH1618A true TH1618A (en) | 1984-06-01 |
Family
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