TH1601006861A - 1 - ((3S, 4R) -4- (3-fluorophenyl) -1- (2-methoxyethyl) pyridin-3-il) -3- (4-methyl- 3- (2-methyl pyrimidin-5-il) -1-phenyl-1H-pyrazol-5-il) urea as a TRKA kinase inhibitor - Google Patents
1 - ((3S, 4R) -4- (3-fluorophenyl) -1- (2-methoxyethyl) pyridin-3-il) -3- (4-methyl- 3- (2-methyl pyrimidin-5-il) -1-phenyl-1H-pyrazol-5-il) urea as a TRKA kinase inhibitorInfo
- Publication number
- TH1601006861A TH1601006861A TH1601006861A TH1601006861A TH1601006861A TH 1601006861 A TH1601006861 A TH 1601006861A TH 1601006861 A TH1601006861 A TH 1601006861A TH 1601006861 A TH1601006861 A TH 1601006861A TH 1601006861 A TH1601006861 A TH 1601006861A
- Authority
- TH
- Thailand
- Prior art keywords
- methyl
- trka kinase
- diseases
- kinase inhibitor
- syndrome
- Prior art date
Links
- 101700043017 NTRK1 Proteins 0.000 title claims abstract 5
- 239000003757 phosphotransferase inhibitor Substances 0.000 title claims abstract 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 2
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 title 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 title 1
- 102100016102 NTRK1 Human genes 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 claims abstract 8
- 210000000988 Bone and Bones Anatomy 0.000 claims abstract 2
- 208000001636 Diabetic Neuropathy Diseases 0.000 claims abstract 2
- 206010012680 Diabetic neuropathy Diseases 0.000 claims abstract 2
- 206010061218 Inflammation Diseases 0.000 claims abstract 2
- 208000002193 Pain Diseases 0.000 claims abstract 2
- 208000000450 Pelvic Pain Diseases 0.000 claims abstract 2
- 230000002159 abnormal effect Effects 0.000 claims abstract 2
- 230000005540 biological transmission Effects 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims abstract 2
- 201000009273 endometriosis Diseases 0.000 claims abstract 2
- 200000000018 inflammatory disease Diseases 0.000 claims abstract 2
- 230000004054 inflammatory process Effects 0.000 claims abstract 2
- 230000000926 neurological Effects 0.000 claims abstract 2
- 230000001717 pathogenic Effects 0.000 claims abstract 2
- 244000052769 pathogens Species 0.000 claims abstract 2
- 201000007094 prostatitis Diseases 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 201000010874 syndrome Diseases 0.000 claims abstract 2
- 210000001519 tissues Anatomy 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
Abstract
สิ่งที่ถูกจัดให้ขึ้นคือสารประกอบ (I) (สูตรเคมี) 1 หรือเกลือที่ยอมรับได้ทางเภสัชกรรมของพวกมัน ที่ซึ่งเป็นยายับยั้ง TrkA ไคเนส และมี ประโยชน์ในการรักษาโรคที่ซึ่งสามารถรักษาได้ด้วยยายับยั้ง TrkA ไคเนส เช่น ความเจ็บปวด , มะเร็ง, การอักเสบ และโรคที่มีการอักเสบ, โรคทางระบบประสาท, โรคติดเชื้อบางโรค, กลุ่มอาการโจเกรน, โรคเยื่อบุโพรงมดลูกเจริญผิดที่, ภาวะระบบประสาทส่วนปลายเสื่อมจาก โรคเบาหวาน, ต่อมลูกหมากอักเสบ, กลุ่มอาการความเจ็บปวดกระดูกเชิงกราน, โรคที่ เกี่ยวข้องกับการเสียสมดุลของการควบคุมของการปรับรูปร่างกระดูกและโรคที่เป็นผลมาจาก การส่งสัญญาณที่ผิดปกติของคอนเน็กทีฟ ทิชชู โกรธ แฟกเตอร์ What is classified is compound (I) (chemical formula) 1 or their pharmacologically acceptable salt. It is a TrkA kinase inhibitor and is useful in the treatment of diseases that can be treated with TrkA kinase inhibitors such as pain, cancer, inflammation and inflammatory disease, neurological disease, infectious disease. Some pathogens, Jogren's syndrome, endometriosis, diabetic neuropathy, prostatitis, pelvic pain syndrome, diseases associated with imbalance of control. Of bone reshaping and diseases resulting from Abnormal signal transmission of the connected tissue angry factor.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH1601006861A true TH1601006861A (en) | 2019-11-18 |
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