WO2005080549A3 - Trioxacarcins and their use against infections - Google Patents

Trioxacarcins and their use against infections Download PDF

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Publication number
WO2005080549A3
WO2005080549A3 PCT/EP2005/001696 EP2005001696W WO2005080549A3 WO 2005080549 A3 WO2005080549 A3 WO 2005080549A3 EP 2005001696 W EP2005001696 W EP 2005001696W WO 2005080549 A3 WO2005080549 A3 WO 2005080549A3
Authority
WO
WIPO (PCT)
Prior art keywords
trioxacarcins
use against
against infections
parasites
fungi
Prior art date
Application number
PCT/EP2005/001696
Other languages
German (de)
French (fr)
Other versions
WO2005080549A2 (en
Inventor
Oliver Kayser
Hartmut Laatsch
Rajendra Prasad Maskey
Friedrich Hansske
Iris Gruen-Wollny
Elisabeth Helmke
Original Assignee
Biofrontera Discovery Gmbh
Oliver Kayser
Hartmut Laatsch
Rajendra Prasad Maskey
Friedrich Hansske
Iris Gruen-Wollny
Elisabeth Helmke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofrontera Discovery Gmbh, Oliver Kayser, Hartmut Laatsch, Rajendra Prasad Maskey, Friedrich Hansske, Iris Gruen-Wollny, Elisabeth Helmke filed Critical Biofrontera Discovery Gmbh
Publication of WO2005080549A2 publication Critical patent/WO2005080549A2/en
Publication of WO2005080549A3 publication Critical patent/WO2005080549A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the use of trioxacarcins as agents for treating infections caused by fungi, parasites, viruses or bacteria. The invention also relates to the novel trioxacarcin derivatives as such, to drugs containing them or the salts thereof and to the use thereof in the treatment of tumors and inflammatory diseases or in the treatment of infections that are caused by fungi, parasites, viruses or bacteria.
PCT/EP2005/001696 2004-02-21 2005-02-18 Trioxacarcins and their use against infections WO2005080549A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004009921.9 2004-02-21
DE102004009921 2004-02-21
DE102004017793.7 2004-04-05
DE102004017793A DE102004017793A1 (en) 2004-02-21 2004-04-05 Use of trioxacarcins for treatment and prevention of infectious diseases, also new trioxacarcins for treatment of e.g. tumors, inflammatory and autoimmune diseases

Publications (2)

Publication Number Publication Date
WO2005080549A2 WO2005080549A2 (en) 2005-09-01
WO2005080549A3 true WO2005080549A3 (en) 2005-12-08

Family

ID=34888817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/001696 WO2005080549A2 (en) 2004-02-21 2005-02-18 Trioxacarcins and their use against infections

Country Status (2)

Country Link
DE (1) DE102004017793A1 (en)
WO (1) WO2005080549A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (en) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc Inhibitors of sodium glucose co-transporter 2 and methods of their use
WO2008109591A1 (en) 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
EP2550285B1 (en) 2010-03-22 2017-07-19 President and Fellows of Harvard College Trioxacarcins and uses thereof
EP2922575B1 (en) * 2012-11-26 2019-06-26 President and Fellows of Harvard College Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof
US20210230178A1 (en) * 2017-08-17 2021-07-29 William Marsh Rice University Trioxacarcin analogs and dimers as potent anticancer agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071428A1 (en) * 1981-07-22 1983-02-09 Kyowa Hakko Kogyo Kabushiki Kaisha Compounds, having antibiotic activity, obtainable by cultivating Streptomyces bottropensis
US4511560A (en) * 1979-10-26 1985-04-16 Kyowa Hakko Kogyo Kabushiki Kaisha Antibiotic substances DC-45, and their use as medicaments

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5865293A (en) * 1981-10-13 1983-04-18 Kyowa Hakko Kogyo Co Ltd Dc-45-a1, dc-er-a2, and their preparations
EP0157203A3 (en) * 1984-04-04 1986-10-01 American Cyanamid Company Antitumor agents ll-d49194 alpha 1, ll-d49194 beta, ll-d49194 beta 2, ll-d49194 upsilon, ll-d49194 delta, ll-d49194 epsilon, ll-d49194 zeta, and ll-d49194 eta

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511560A (en) * 1979-10-26 1985-04-16 Kyowa Hakko Kogyo Kabushiki Kaisha Antibiotic substances DC-45, and their use as medicaments
EP0071428A1 (en) * 1981-07-22 1983-02-09 Kyowa Hakko Kogyo Kabushiki Kaisha Compounds, having antibiotic activity, obtainable by cultivating Streptomyces bottropensis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FUJIMOTO, KAZUHISA ET AL: "Antitumor activity of trioxacarcin C", JOURNAL OF ANTIBIOTICS , 36(9), 1216-21 CODEN: JANTAJ; ISSN: 0021-8820, 1983, XP008048950 *
MASKEY, RAJENDRA P. ET AL: "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry", JOURNAL OF ANTIBIOTICS , 57(12), 771-779 CODEN: JANTAJ; ISSN: 0021-8820, 2004, XP008048955 *
TAMAOKI, TATSUYA ET AL: "Trioxacarcins, novel antitumor antibiotics. II. Isolation, physicochemical properties and mode of action", JOURNAL OF ANTIBIOTICS , 34(12), 1525-30 CODEN: JANTAJ; ISSN: 0021-8820, 1981, XP008048951 *
TOMITA, FUSAO ET AL: "Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities", JOURNAL OF ANTIBIOTICS , 34(12), 1519-24 CODEN: JANTAJ; ISSN: 0021-8820, 1981, XP008048954 *

Also Published As

Publication number Publication date
WO2005080549A2 (en) 2005-09-01
DE102004017793A1 (en) 2005-09-08

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