TH158380A - Bis (fluoroalkyl) -1,4-benzodiazepinone compounds As a deterrent Notch - Google Patents
Bis (fluoroalkyl) -1,4-benzodiazepinone compounds As a deterrent NotchInfo
- Publication number
- TH158380A TH158380A TH1501001590A TH1501001590A TH158380A TH 158380 A TH158380 A TH 158380A TH 1501001590 A TH1501001590 A TH 1501001590A TH 1501001590 A TH1501001590 A TH 1501001590A TH 158380 A TH158380 A TH 158380A
- Authority
- TH
- Thailand
- Prior art keywords
- deterrent
- fluoroalkyl
- bis
- notch
- compound
- Prior art date
Links
- 125000003709 fluoroalkyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 239000000126 substance Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 102000005650 Notch Receptors Human genes 0.000 abstract 1
- 108010070047 Notch Receptors Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229940079593 drugs Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000000529 probiotic Effects 0.000 abstract 1
- 239000006041 probiotic Substances 0.000 abstract 1
- 235000018291 probiotics Nutrition 0.000 abstract 1
Abstract
ที่เปิดเผยคือ สารประกอบของสูตร (I) และ/หรือเกลือของมัน (สูตรเคมี) (I) ซึ่ง R1 คือ -CH2CH2CF3; R2 คือ -CH2CH2CF3 หรือ -CH2CH2CH2CF3; R3 คือ H, -CH3, หรือ Rx; R4 คือ H หรือ Ry; วงแหวน A คือ เฟนิล หรือ พิริดินิล; และนิยาม Rx, Ry, Ra, Rb, y, และ z ไว้ในที่นี้ ที่ เปิดเผยด้วยเช่นกัน คือ วิธีการใช้สารประกอบดังกล่าวเพื่อยับยั้ง Notch รีเซปเตอร์, และองค์ประกอบ ทางเภสัชกรรมซึ่งประกอบรวมด้วยสารประกอบดังกล่าว สารประกอบเหล่านี้เป็นประโยชน์ในการ บำบัด, การป้องกันม หรือการชะลอการลุกลามของโรคหรือความผิดปกติในบริเวณที่บำบัดต่างๆ, อย่างเช่น มะเร็ง; หรือเป็นโพรดรักของสารประกอบดังกล่าว: สิทธิบัตรยา Disclosed is Compound of formula (I) and / or its salt (chemical formula) (I), where R1 is -CH2CH2CF3; R2 is -CH2CH2CF3 or -CH2CH2CH2CF3; R3 is H, -CH3, or Rx; R4 is H or Ry; Ring A is phenyl or piridinil; And here are the definitions of Rx, Ry, Ra, Rb, y, and z. Also disclosed is how the compound is used to inhibit Notch receptors, and its constituents. Pharmaceuticals, including those compounds These compounds are useful in treating, preventing or slowing the progression of disease or disorders in treatment areas, such as cancer; Or is it the probiotic of that compound: drug patents?
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH158380A true TH158380A (en) | 2016-12-02 |
| TH1501001590A TH1501001590A (en) | 2016-12-02 |
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