TH149042B - Preparation of replaced tetrahydropyran spiropyridinone And Piperidinone And its therapeutic uses - Google Patents
Preparation of replaced tetrahydropyran spiropyridinone And Piperidinone And its therapeutic usesInfo
- Publication number
- TH149042B TH149042B TH901005424A TH0901005424A TH149042B TH 149042 B TH149042 B TH 149042B TH 901005424 A TH901005424 A TH 901005424A TH 0901005424 A TH0901005424 A TH 0901005424A TH 149042 B TH149042 B TH 149042B
- Authority
- TH
- Thailand
- Prior art keywords
- replaced
- phenyl
- spiropyridinone
- piperidinone
- tetrahydropyran
- Prior art date
Links
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title 1
- -1 tetrahydropyran spiropyridinone Chemical compound 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
- 150000003857 carboxamides Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- KFIOZBMCNUODPK-UHFFFAOYSA-N n-phenyl-1-pyrrolidin-1-ylpyrrolidine-2-carboxamide Chemical class C1CCN(N2CCCC2)C1C(=O)NC1=CC=CC=C1 KFIOZBMCNUODPK-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เปิดเผยและอ้างสิทธิในชุดของ N-เฟนิล-ไบไพโรลิดีน คาร์บอกซาไมด์ ที่ถูกแทนที่ (substituted N-phenyl-bipyrrolidine carboxamides)ของสูตร (I) (สูตรเคมี) (I) ซึ่ง R1, R2, m, n และ p เป็นไปตามที่ได้อธิบายไว้ในที่นี้ ที่เฉพาะเจาะจงมากขึ้น สารประกอบต่างๆ ของการประดิษฐ์นี้ เป็นตัวควบคุมของตัวรับ H3 และเป็นประโยชน์ในฐานะที่เป็นสารทางเภสัชกรรม โดยเฉพาะในการใช้รักษา และ/หรือ ป้องกันโรคอันหลากหลาย ซึ่งถูกควบคุมโดยตัวรับ H3 รวมถึง โรคต่างๆ ที่สัมพันธ์กับระบบประสาทส่วนกลาง นอกจากนี้แล้ว การประดิษฐ์นี้ยังเปิดเผยถึงวิธีการ เตรียม N-เฟนิล-ไบไพโรลิดีน คาร์บอกซาไมด์ที่ถูกแทนที่ และสารระหว่างทางต่างๆ ตามนั้น This invention discloses and claims a set of N-phenyl-bypyrolidine Carboxamide that is substituted (substituted N-phenyl-bipyrrolidine carboxamides) of the formula (I) (chemical formula) (I), where R1, R2, m, n, and p are described here. More specific Various compounds Of this invention It is a regulator of H3 receptors and is useful as a pharmaceutical substance. Especially in the treatment and / or prevention of a wide range of diseases Which is controlled by the H3 receptor, including diseases related to the central nervous system In addition The invention also revealed a method for preparing N-phenyl-bypyrolidine. Replaced carboxamides And messages along the way accordingly
Claims (1)
Publications (4)
| Publication Number | Publication Date |
|---|---|
| TH901005424A TH901005424A (en) | |
| TH149042A TH149042A (en) | 2016-04-26 |
| TH149042B true TH149042B (en) | 2016-04-26 |
| TH0901005424A TH0901005424A (en) | 2016-04-26 |
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