TH14841EX - Granulation - Google Patents

Abstract

A process for granulation, which is pre-treated Carrier contains diluents, binders, and may also contain dispersants. In a container separated from the carrier They provide steroids, lubricants, and possibly anti-oxidants, dissolved in organic solvents that may be pre-heated. The resulting solution was put into the substance. Bring in a mixer such as a vacuum mixer. Then mix the mixture further, removing the organic solvent from the mixture. The mixture is further mixed to form a granulation. The process also introduces a flow promoting agent, such as colloidal silicon dioxide, into the granulation granules for making a dose unit into a granule. Characteristic granules consisting of a) a carrier containing a diluent and a binder and b) such a film-like carrier coat.The film contains a disogester and lubricant. And has specific characteristics The dezogestrail was stored 90% at a pressure of 150 mbar and a temperature of 70 ° C for 72 hours.

Claims (2)

1. The process for granulation containing steroids consists of a) dissolving steroids and lubricants in organic solvents in A sufficient amount to form a solution, b) mixing this solution with a carrier containing a diluent and a fixing agent, thus forming a mixture of the solution and the carrier and c) removing the organic solvent from the mixture while Mix the mixture to Make granulation where the steroid is 2. Process according to claim 1 in which INSEE solvent