TH137267B - Process for the preparation of methyl (4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-il] pi Rimidin-5-il) methylcarbamate (methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl) ] pyrimidin-5-yl} methylcarbamate) and purification for use as an active pharmaceutical ingredient. - Google Patents
Process for the preparation of methyl (4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-il] pi Rimidin-5-il) methylcarbamate (methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl) ] pyrimidin-5-yl} methylcarbamate) and purification for use as an active pharmaceutical ingredient.Info
- Publication number
- TH137267B TH137267B TH1201002485A TH1201002485A TH137267B TH 137267 B TH137267 B TH 137267B TH 1201002485 A TH1201002485 A TH 1201002485A TH 1201002485 A TH1201002485 A TH 1201002485A TH 137267 B TH137267 B TH 137267B
- Authority
- TH
- Thailand
- Prior art keywords
- methyl
- pyrazolo
- fluorobenzyl
- diamino
- pyridin
- Prior art date
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title claims abstract 7
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 title claims abstract 6
- 238000000034 method Methods 0.000 title claims abstract 3
- 238000002360 preparation method Methods 0.000 title claims 2
- 238000000746 purification Methods 0.000 title abstract 3
- HEZNVIYQEUHLNI-UHFFFAOYSA-N Ethiofencarb Chemical compound CCSCC1=CC=CC=C1OC(=O)NC HEZNVIYQEUHLNI-UHFFFAOYSA-N 0.000 title 1
- 239000008186 active pharmaceutical agent Substances 0.000 title 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 title 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- OJVAMHKKJGICOG-UHFFFAOYSA-N Hexane-2,5-dione Chemical compound CC(=O)CCC(C)=O OJVAMHKKJGICOG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 methyl carbohydrate Chemical class 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับกระบวนการสำหรับเตรียมเมทิล {4,6-ไดอะมิโน-2-[1-(2- ฟลูออโรเบนซิล)-1H-ไพราโซโล[3,4-b]ไพริดิน-3-อิล]ไพริมิดิน-5-อิล}เมทิลคาร์บาเมตตามสูตร (I) (สูตรเคมี) (I) และกระบวนการสำหรับทำให้ผลิตภัณฑ์ดิบของสารประกอบตามสูตร (I) มีความบริสุทธิ์สำหรับใช้ เป็นสารออกฤทธิ์ทางเภสัชกรรม โดยที่ในการทำให้บริสุทธิ์นั้น เมทิล {4,6-ไดอะมิโน-2-[1-(2- ฟลูออโรเบนซิล)-1H-ไพราโซโล[3,4-b]ไพริดิน-3-อิล] ไพริมิดิน-5-อิล}เมทิลคาร์บาเมตซักฟินิล ไดมีเทน (11) กล่าวคือสารประกอบตามสูตร (II) ถูกแยกเดี่ยวในรูปของสารมัธยันตร์หรือถูกทำให้ เกิดขึ้นในฐานะสารมัธยันตร์ในกระบวนการทำให้บริสุทธิ์นี้ โดยอยู่ในของผสมถ้าเหมาะสม: This invention involves a process for preparing methyl. (4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-il] pi Rimidin-5-il) methyl carbohydrate formula (I) (chemical formula) (I) and process for purifying the raw product of formula (I) compound for use. It is an active ingredient in pharmaceuticals. Where in the purification, methyl {4,6-diamino-2- [1- (2- fluorobenzyl) -1H-pyrazolo [3,4-b] pyrid Soil-3-il] pyrimidin-5-il} methylcarbamate, succinyl dimethane (11), ie the compound according to formula (II) is isolated as a methyl or Was made Takes place as a substance in this purification process In the mix if appropriate:
Claims (1)
Publications (1)
Publication Number | Publication Date |
---|---|
TH137267B true TH137267B (en) | 2014-10-09 |
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