TH137267A - Process for the preparation of methyl (4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-il] pi Rimidin-5-il) methylcarbamate (methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl) ] pyrimidin-5-yl} methylcarbamate) and purification for use as an active pharmaceutical ingredient. - Google Patents
Process for the preparation of methyl (4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-il] pi Rimidin-5-il) methylcarbamate (methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl) ] pyrimidin-5-yl} methylcarbamate) and purification for use as an active pharmaceutical ingredient.Info
- Publication number
- TH137267A TH137267A TH701003757A TH0701003757A TH137267A TH 137267 A TH137267 A TH 137267A TH 701003757 A TH701003757 A TH 701003757A TH 0701003757 A TH0701003757 A TH 0701003757A TH 137267 A TH137267 A TH 137267A
- Authority
- TH
- Thailand
- Prior art keywords
- fluorobenzyl
- pyrazolo
- methyl
- pyridin
- methylcarbamate
- Prior art date
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title claims abstract 8
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 title claims abstract 6
- 238000000034 method Methods 0.000 title claims abstract 4
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 title claims 4
- 238000002360 preparation method Methods 0.000 title claims 2
- 238000000746 purification Methods 0.000 title abstract 5
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 title abstract 4
- 239000008186 active pharmaceutical agent Substances 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 125000004175 fluorobenzyl group Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- OJVAMHKKJGICOG-UHFFFAOYSA-N 2,5-hexanedione Chemical compound CC(=O)CCC(C)=O OJVAMHKKJGICOG-UHFFFAOYSA-N 0.000 abstract 1
Abstract
DC60(28/05/55) การประดิษฐ์นี้เกี่ยวข้องกับกระบวนการสำหรับเตรียมเมทิล{4,6ไดอะมิโน2[1(2 ฟลูออโรเบนซิล)1Hไพราโซโล[3,4b]ไพริดิน3อิล]ไพริมิดิน5อิล}เมทิลคาร์บาเมตตามสูตร(I) (สูตรเคมี) (I) และกระบวนการสำหรับทำให้ผลิตภัณฑ์ดิบของสารประกอบตามสูตร(I)มีความบริสุทธิ์สำหรับใช้ เป็นสารออกฤทธิ์ทางเภสัชกรรมโดยที่ในการทำให้บริสุทธิ์นั้นเมทิล{4,6ไดอะมิโน2[1(2 ฟลูออโรเบนซิล)1Hไพราโซโล[3,4b]ไพริดิน3อิล]ไพริมิดิน5อิล}เมทิลคาร์บาเมตซัลฟินิล ไดมีเทน(1:1)กล่าวคือสารประกอบตามสูตร(II)ถูกแยกเดี่ยวในรูปของสารมัธยันตร์หรือถูกทำให้ เกิดขึ้นในฐานะสารมัธยันตร์ในกระบวนการทำให้บริสุทธิ์นี้โดยอยู่ในของผสมถ้าเหมาะสม การประดิษฐ์นี้เกี่ยวข้องกับกระบวนการสำหรับเตรียมเมทิล{4,6ไดอะมิโน2[1(2 ฟลูออโรเบนซิล)1Hไพราโซโล[3,4b]ไพริดิน3อิล]ไพริมิดิน5อิล}เมทิลคาร์บาเมตตามสูตร(I) (สูตรเคมี) (I) และกระบวนการสำหรับทำให้ผลิตภัณฑ์ดิบของสารประกอบตามสูตร(I)มีความบริสุทธิ์สำหรับใช้ เป็นสารออกฤทธิ์ทางเภสัชกรรมโดยที่ในการทำให้บริสุทธิ์นั้นเมทิล{4,6ไดอะมิโน2[1(2 ฟลูออโรเบนซิล)1Hไพราโซโล[3,4b]ไพริดิน3อิล]ไพริมิดิน5อิล}เมทิลคาร์บาเมตซักฟินิล ไดมีเทน(1:1)กล่าวคือสารประกอบตามสูตร(II)ถูกแยกเดี่ยวในรูปของสารมัธยันตร์หรือถูกทำให้ เกิดขึ้นในฐานะสารมัธยันตร์ในกระบวนการทำให้บริสุทธิ์นี้โดยอยู่ในของผสมถ้าเหมาะสม DC60(28/05/12) The present invention relates to a process for preparing methyl{4,6diamino2[1(2). fluorobenzyl)1H pyrazolo[3,4b]pyridin3yl]pyrimidin5yl}methylcarbamet according to formula (I) (chemical formula) (I) and Process for purifying raw products of formula (I) compounds for use. It is a pharmaceutical active substance where in purification it is methyl{4,6diamino2[1(2 fluorobenzyl)1Hpyrazolo[3,4b]pyridine3yl]pyrimidine5yl}methylcarbamatesulfinyl Dimethane (1:1), that is, a compound of formula (II), is isolated in the form of an intermediate or reduced. Occurs as an intermediate in this purification process in the mixture if appropriate. The present invention relates to a process for preparing methyl{4,6diamino2[1(2). fluorobenzyl)1H pyrazolo[3,4b]pyridin3yl]pyrimidin5yl}methylcarbamet according to formula (I) (chemical formula) (I) and Process for purifying raw products of formula (I) compounds for use. It is a pharmaceutical active substance where in purification it is methyl{4,6diamino2[1(2 fluorobenzyl)1Hpyrazolo[3,4b]pyridin3yl]pyrimidin5yl}methylcarbamate succinyl Dimethane (1:1), that is, a compound of formula (II), is isolated in the form of an intermediate or reduced. Occurs as an intermediate in this purification process in the mixture if appropriate.
Claims (1)
Publications (4)
Publication Number | Publication Date |
---|---|
TH93993A TH93993A (en) | 2009-02-27 |
TH137267A true TH137267A (en) | 2014-10-09 |
TH93993B TH93993B (en) | 2014-10-09 |
TH60441B TH60441B (en) | 2018-02-02 |
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