TH135903B - Diphenyl-Pirazolopyridine derivatives, their preparations, and their use as a regulator. NUCLEAR RECEPTOR NOT. - Google Patents
Diphenyl-Pirazolopyridine derivatives, their preparations, and their use as a regulator. NUCLEAR RECEPTOR NOT.Info
- Publication number
- TH135903B TH135903B TH1201002610A TH1201002610A TH135903B TH 135903 B TH135903 B TH 135903B TH 1201002610 A TH1201002610 A TH 1201002610A TH 1201002610 A TH1201002610 A TH 1201002610A TH 135903 B TH135903 B TH 135903B
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- hydroxyl
- group
- hydrogen
- alkyls
- Prior art date
Links
- 108020004017 nuclear receptors Proteins 0.000 title abstract 2
- 102000006255 nuclear receptors Human genes 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 10
- 125000005843 halogen group Chemical group 0.000 claims abstract 7
- -1 halos (C1-C6) alkyls Chemical group 0.000 claims abstract 5
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000004429 atoms Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 101710004289 RRM1 Proteins 0.000 abstract 3
- 102100015989 NR4A2 Human genes 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001225 therapeutic Effects 0.000 abstract 2
- 101710003190 ZNF268 Proteins 0.000 abstract 1
- 102100006508 ZNF268 Human genes 0.000 abstract 1
- 230000002378 acidificating Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวกับสูตร (I), ซึ่ง R คือไฮโดรเจน หรือเฮโลเจนอะตอม หรือ หมู่ (C1-C6) แอลคิล; X คือหมู่แทนที่หนึ่งหมู่หรือมากกว่าที่เลือกจากไฮโดรเจนหรือเฮโลเจนอะตอม, หมู่ (C1-C6)แอลคิล, เฮโล(C1-C6)แอลคิล, (C1-C6)แอลคอกซิ, เฮโล(C1-C6)แอลคอกซิ, ไซยาโน, ไฮดรอกซิ, หรือไฮดรอกซิ(C1-C6)แอลคิล; Y คือไฮโดรเจน หรือเฮโลเจนอะตอม หรือ หมู่ (C1-C6)แอลคิล; R1 คือหมู่ NR2R3 หรือ OR4; R2 และ R3 เป็นอิสระต่อกันคือไฮโดรเจนอะตอม, หมู่ (C1-C6)แอลคิล, ไฮดรอกซิ(C1-C6)แอลคิล หรือออกโซ(C1-C6)แอลคิล หรือ R2 และ R3, รวมตัว กับไนโตรเจนอะตอมซึ่งมีหมู่เหล่านี้ต่ออยู่, เกิดเป็นเฮเทอโรไซเคิล ซึ่งเลือกถูกแทนที่โดย หมู่ (C1-C6)แอลคิล, ไฮดรอกซิหรือออกโซ; และ R4 คือหมู่ (C1-C6)แอลคิล, ไฮดรอกซิ(C1-C6)แอลคิล, หรือออกโซ(C1-C6)แอลคิล, ในรูปของเบสหรือเกลือที่เกิดจากการรวมตัว กับกรด สูตรดังกล่าวสมารถใช้ในการบำบัดโรคสำหรับรักษาหรือป้องกันโรคที่สัมพันธ์กับ นิวเคลียร์ รีเซพเตอร์ Nurr-1, ที่รู้จักเช่นกันเป็น NR4A2, NOT, TINUR, RNR-1, และ HZF3 This invention is about the formula (I), where R is a hydrogen or a halogen atom or a group (C1-C6) alkyl; X is one or more substituting groups selected from hydrogen or halogen atoms, (C1-C6) alkyls, halos (C1-C6) alkyls, (C1-C6) alkoxies, halo. (C1-C6) alkyl, cyano, hydroxyl, or hydroxyl (C1-C6) alkyl; Y is a hydrogen or a halogen atom or a group (C1-C6) alkyl; R1 is group NR2R3 or OR4; R2 and R3 are independent hydrogen atoms, group (C1-C6) alkyl, hydroxyl (C1-C6) alkyl. Or oxo (C1-C6) alkyl or R2 and R3, merging with nitrogen atoms which have these groups connected, forming a heterocycle. Which is chosen to be replaced by moo (C1-C6) alkyl, hydroxyl or oxo; And R4 is moo (C1-C6) alkyl, hydroxyl (C1-C6) alkyl, or oxo (C1-C6) alkyl, in the form of a base or salt formed by This combination with acidic formulations can be used in therapeutic, therapeutic, or prophylactic treatment of disease associated with nuclear receptor Nurr-1, also known as NR4A2, NOT, TINUR, RNR-1, and HZF3.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH135903B true TH135903B (en) | 2014-08-18 |
| TH135903A TH135903A (en) | 2014-08-18 |
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