TH134115B - Use of substances in the imidaso group [1,2-C] pyrimidine substituted at position 5,7 as a JAK kinase inhibitor. - Google Patents
Use of substances in the imidaso group [1,2-C] pyrimidine substituted at position 5,7 as a JAK kinase inhibitor.Info
- Publication number
- TH134115B TH134115B TH1201005434A TH1201005434A TH134115B TH 134115 B TH134115 B TH 134115B TH 1201005434 A TH1201005434 A TH 1201005434A TH 1201005434 A TH1201005434 A TH 1201005434A TH 134115 B TH134115 B TH 134115B
- Authority
- TH
- Thailand
- Prior art keywords
- substances
- jak kinase
- imidaso
- group
- kinase inhibitor
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 3
- 201000010099 disease Diseases 0.000 abstract 4
- 206010003816 Autoimmune disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000000056 organs Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 210000001519 tissues Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Abstract
สารประกอบที่มีสูตรโครงสร้างที่ Iชนิดต่าง ๆ ( สูตรคมี ) และสเตอริโอไอโซเมอร์ชนิดต่าง ๆ และเกลือและสารที่เกิดจากปฏิกิริยาของตัวทำละลายและตัวถูก ละลายที่เป็นที่ยอมรับทางเภสัชกรรมชนิดต่าง ๆ ของสารประกอบดังกล่าว ซึ่ง R1,R2,R3,R4,R5, R6,R7,X1และ X2 มีความหมายตามที่ให้ไว้รายละเอียดการประดิษฐ์ เป็นสารยับยั้ง JAK ไคเนสหนึ่งหรือมากกว่านั้น และเป็นประโยชน์ในการรักษาโรคภูมิต้านตนเอง โรคทีเกิดจาก การอักเสบ การปฏิเสธอวัยวะ เนื้อเยื่อ และเซลล์ปลูกถ่าย รวมทั้งความผิดปกติและมะเร็งใน ระบบเลือก และภาวะการเจ็บป่วยร่วมจากโรคหรือความผิดปกติดังกล่าว Compounds with various I-type structural formulas (formula Cm) and different types of stereoisomers and salts and substances formed by the reaction of solvents and solvents Various pharmaceutical dissolves of such compounds, of which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given, the fabrication details. It is one or more JAK kinase inhibitors. And it is useful in the treatment of autoimmune diseases, diseases caused by inflammation, rejection of organs, tissues and transplantation cells. Including disorders and elective cancer and co-morbidity from such diseases or disorders.
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH134115B true TH134115B (en) | 2014-05-29 |
TH134115A TH134115A (en) | 2014-05-29 |
Family
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