TH131372B - 3- [4- (7H-pyrolo [2, 3-D] pyrimidin-4-il) -1H-pyrazol-1-il] octane nitrile or heparin. Phthane-Nitrile That is a JAK inhibitor (3- [4-7H-PYRROLO [2,3-D] PYRIMIDIN-4-YL) -1H-PYRAZOL-1-YL] OCTANE- or HEPTANE-NITRILE AS JAK INHIBITORS) - Google Patents
3- [4- (7H-pyrolo [2, 3-D] pyrimidin-4-il) -1H-pyrazol-1-il] octane nitrile or heparin. Phthane-Nitrile That is a JAK inhibitor (3- [4-7H-PYRROLO [2,3-D] PYRIMIDIN-4-YL) -1H-PYRAZOL-1-YL] OCTANE- or HEPTANE-NITRILE AS JAK INHIBITORS)Info
- Publication number
- TH131372B TH131372B TH1101003234A TH1101003234A TH131372B TH 131372 B TH131372 B TH 131372B TH 1101003234 A TH1101003234 A TH 1101003234A TH 1101003234 A TH1101003234 A TH 1101003234A TH 131372 B TH131372 B TH 131372B
- Authority
- TH
- Thailand
- Prior art keywords
- nitrile
- pyrimidin
- pyrazol
- octane
- pyrolo
- Prior art date
Links
- SDAXRHHPNYTELL-UHFFFAOYSA-N heptanenitrile Chemical compound CCCCCCC#N SDAXRHHPNYTELL-UHFFFAOYSA-N 0.000 title claims abstract 5
- YSIMAPNUZAVQER-UHFFFAOYSA-N octanenitrile Chemical compound CCCCCCCC#N YSIMAPNUZAVQER-UHFFFAOYSA-N 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title 1
- 229960002897 Heparin Drugs 0.000 title 1
- 229920000669 heparin Polymers 0.000 title 1
- RJKGJBPXVHTNJL-UHFFFAOYSA-N 1-nitronaphthalene Chemical compound C1=CC=C2C([N+](=O)[O-])=CC=CC2=C1 RJKGJBPXVHTNJL-UHFFFAOYSA-N 0.000 claims 1
- 229940073020 Nitrol Drugs 0.000 claims 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N Octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 4
- 206010003816 Autoimmune disease Diseases 0.000 abstract 1
- 241001580017 Jana Species 0.000 abstract 1
- 208000006641 Skin Disease Diseases 0.000 abstract 1
- 230000002757 inflammatory Effects 0.000 abstract 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารยับยั้งเจนัสไคเนส (Janas Kinese)(JAK)ของ 3-[4-(7H- ไพร์โรโล[2,3-d]ไพริมิดิน-4-อิล)-1H-ไพราซอล-1-อิล] ออกเทนไนไตรล์ (3-[4-(7H-ไพร์โรโล[2,3- d]ไพริมิดิน-4-อิล)-1H-ไพราซอล-1-อิล]cotanenitrile)หรือ 3-[4-(7H-ไพร์โรโล[2,3-d]ไพริมิดิน-4- อิล)-1H-ไพราซอล-1-อิล]เฮพเทนไนไตรล์ (3-[4-(7H-ไพร์โรโล[2,3-d]ไพริมิดิน-4-yl)-1H-ไพรา ซอล-1-อิล]เฮพเทนไนไตรล์)ตลอดจนองค์ประกอบของมันและวิธีการใช้ ซึ่งมีประโยชน์ในการ บำบัดโรคที่เกี่ยวข้องกับ JAK ที่รวมถึง ตัวอย่างเช่น การอักเสบ (inflammatory) และความผิดปกติของโรค ที่เป็นภาวะที่มีภูมิต้านทานต่อตัวเอง (autoimmune disorders), ความผิดปกติของโรคทางผิวหนัง,โรคมะเร็ง และโรคอื่นๆ The invention involved a Janas Kinese (JAK) inhibitor of 3- (4- (7H-pyrrolol [2,3-d] pyrimidin-4-il)). -1H-pyrazol-1-il] octane nitrile (3- (4- (7H-pyrolo [2,3-d] pyrimidin-4-il) -1H-pyrazol-1-il) cotanenitrile) or 3- [4- (7H-pirolo [2,3-d] pyrimidin-4-il) -1H-pyrazol-1-il] heptane nitrile (3- [4- (7H-pyrolo [2,3-d] pyrimidin-4-yl) -1H-pira Sol-1-il] Heptane Nitrile) as well as its composition and method of use. Which is useful in Treat JAK-related diseases including, for example, inflammatory and disease disorders. With autoimmune disorders, skin disorders, cancer and other diseases
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH131372A TH131372A (en) | 2014-02-27 |
| TH131372B true TH131372B (en) | 2014-02-27 |
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