TH13075A3 - Drug composition using pineapple starch was chemically modified by carboxymethylation reaction. (carboxymethylation) is a splitting agent in tablets for industrial use. And the process for preparing this drug component - Google Patents

Abstract

Drug composition using pineapple starch was chemically modified by carboxymethylation reaction. (carboxymethylation) is a splitting agent in tablets for industrial use. And the process for preparing this drug component It is made by preparing modified pineapple starch mixed with cracking agent and excipient. With mixer After that, add the slurry agent and mix it together for 2 minutes, then hammer the resulting mixture into tablets. For application in the pharmaceutical industry and also Relying on the principles of green technology Since the pineapple starch obtained from the stems and rhizomes is a natural waste material that can be degraded naturally. As a result, reduce the amount of waste and pollution to the environment as well as add value to the remaining materials. And substitute for importing chemicals from abroad

Claims (7)

1. The composition of the tablets contains dispersants. (Pineapple flour, modified carboxymethyl), 2-6% by weight, 0.75% by weight, 0.75% by weight, 93.25-97.25% by weight 2. Tablet composition According to claim 1, where the slippery agent can be selected from Stearic acid group and stearic acid salt 3. Tablet composition According to claim 1 or 2, where the stearic acid salt is magnesium stearate. 4. The composition of the tablets According to one of the claims 1-3, where the excipient can be selected from the excipient group, it is dibasis calcium phosphate, spray dried lactose. 5.The composition of the tablets According to one of the claims 1-4, where the appropriate amount of carboxymethyl pineapple modified starch for normal split type tablets is 2% by weight. 6.The composition of the tablets According to one of the claims 1-5, where the optimal amount of carboxymethyl-modified pineapple starch for fast-disintegrating tablets is 6% by weight. 7. Preparation process for tablet composition Where the steps are A. Preparation of carboxymethyl modified pineapple starch by mixing 63.5 g of absolute methanol with 6.9 g of monochloroacetic acid. B. Add 27.25 g of pineapple flour and blended with a stirrer. 200 rpm magnetic stirrer (rpm) in a closed system. C. Add a 50% alkaline solution by weight of 27.5 g, heated at 60 ° C for 60 min. There is a reaction between the starch molecule and monochloroacetic acid. D. The modified starch obtained was adjusted to pH to 7 with glacial acetic acid. Wash modified starch with 80% methanol by volume several times until no sodium chloride was found, then rinse again. Absolute methanol It was then dried at 60 ° C for 12 hours. The modified starch dried through No. 100 mineral and stored in a desiccator bowl for use as an additive. Help break down in the recipe for tablets The displacement of modified starch was 0.08 e. Mix 2-6% by wt. And 93.25-97.25% by weight excipients together for 5 min by mixer. F. After that add 0.75% by weight slippery agent, mix it up for 2 minutes and then press The resulting mixture is a tablet. By using a hydraulic tablet press machine with a force of 1-2 tons for 5-20 seconds, using a 6.35 mm diameter unravel set to produce tablets weighing 200 mg.