TH130492B - 5-amino-4-hydroxy pentoyyl amide - Google Patents
5-amino-4-hydroxy pentoyyl amideInfo
- Publication number
- TH130492B TH130492B TH1201002059A TH1201002059A TH130492B TH 130492 B TH130492 B TH 130492B TH 1201002059 A TH1201002059 A TH 1201002059A TH 1201002059 A TH1201002059 A TH 1201002059A TH 130492 B TH130492 B TH 130492B
- Authority
- TH
- Thailand
- Prior art keywords
- chemical formula
- alkyl
- pentoyyl
- amide
- hydroxy
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 14
- -1 C1-4 alkoxi Chemical group 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Abstract
สารยับยั้ง HIV ของสูตรโครงสร้าง (สูตรเคมี) (I) ในที่ซึ่ง R1 คือ ฮาโล, C1-4อัลคอกซี, ไตรฟลูออโรเมทธอกซี ; R2 คือ (สูตรเคมี หน้า 1) ; R3 คือ: (สูตรเคมี) , (สูตรเคมี) , (สูตรเคมี) , (สูตรเคมี) ; R4 คือ: (สูตรเคมีหน้า 1) n คือ 0 หรือ 1; A คือ CH หรือ N; R5 และ R6 คือ ไฮโดรเจน, C1-4อัลคิล, ฮาโล; R7 และ R8 คือ C1-4 อัลคิล หรือ C1-4 อัลคอกซี C1-4อัลคิล; R9 คือ C1-4อัลคิล, ไซโคลโพรพิล, ไตรฟลูออโรเมทธิล, C1-4อัลคอกซี, หรือไดเมทธิลอะมิโน; R10 คือ ไฮโดรเจน, C1-4อัลคิล, ไซโคลโพรพิล, ไตรฟลูออโร เมทธิล, C1-4อัลคอกซี, หรือไดเมทธิลอะมิโน; เกลือที่มีการเติมและโซลเวตของมันที่ยอมรับได้ทาง เภสัชกรรม ; องค์ประกอบทางเภสัชกรรมที่มีสารประกอบเหล่านี้ในการเป็นส่วนประกอบออกฤทธิ์และ กระบวนการสำหรับการเตรียมสารประกอบดังกล่าว: HIV inhibitors of the structural formula (chemical formula) (I), where R1 is halo, C1-4 alkoxy, trifluoromethoxy; R2 is (chemical formula page 1); R3 is: ( Chemical formula), (Chemical formula), (Chemical formula), (Chemical formula); R4 is: (Chemical formula p.1) n is 0 or 1; A is CH or N; R5 and R6 is hydrogen, C1-4 alkyl, Ha. Lo; R7 and R8 are C1-4 alkyl or C1-4 alkoxy, C1-4 alkyl; R9 is C1-4 alkyl, cyclopropyl, trifluoromethyl, C1-4 alkoxi, or dimethylamino; R10 is hydrogen, C1-4 alkyl, cyclopropyl, trifluoromethyl, C1-4 alkoxi, or dimethylamino; The added salt and its solvates are pharmacologically acceptable; Pharmaceutical components that contain these active ingredients and The process for preparing such compounds:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH130492B true TH130492B (en) | 2013-12-25 |
| TH130492A TH130492A (en) | 2013-12-25 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JOP20190070B1 (en) | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | |
| PH12016502037A1 (en) | Certain amino-pyrimidines, compositions thereof, and methods for their use | |
| EA201300200A1 (en) | N - ((6-AMINOPIRIDIN-3-IL) METHYL) HETEROARILKARBOXAMIDES AS KALLYCREIN INHIBITORS IN PLASMA | |
| MX344669B (en) | Novel anti-platelet agent. | |
| WO2012007869A3 (en) | N- sulfonylbenzamides as inhibitors of voltage - gated sodium channels | |
| EA201200938A1 (en) | IMIDAZOPIRIDINE DERIVATIVES AS JAK INHIBITORS | |
| EA201201677A1 (en) | DERIVATIVES OF HETEROARILIMIDAZOLONE AS JAK INHIBITORS | |
| MX2015010354A (en) | C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv. | |
| ATE440833T1 (en) | ANTITHRBOTIC DIAMIDES | |
| ATE500222T1 (en) | BENZAMIDE AND HETEROARE DERIVATIVES AS CETP INHIBITORS | |
| MX2012006805A (en) | Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors. | |
| FI20115234A0 (en) | New pyridazinone and pyridone compounds | |
| UA114325C2 (en) | PHENOXYETHYLPIPERIDINE COMPOUNDS | |
| CY1111102T1 (en) | 2- (4-Cyanophenyl) -6-hydroxylaminopyrimidines that inhibit HIV | |
| PH12014502285A1 (en) | Anti-malarial agents | |
| TN2016000061A1 (en) | Amide derivatives as lysophosphatidic acid receptor antagonists | |
| PE20140629A1 (en) | DERIVATIVES OF PHENYL-ISOXAZOLE AND PROCEDURE FOR THE PREPARATION OF THE SAME | |
| CO6341560A2 (en) | PROCESS FOR THE PREPARATION OF SUBSTITUTED PIRIMIDINE DERIVATIVES. | |
| EA201200726A1 (en) | SYNTHESIS METHOD, CRYSTALLINE FORM 4- {3- [CIS-HEXAHYDROCYCLOPENT [C] PYRROL-2 (1H) IL] PROPOXI} BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS, WHICH AE-TUR-JI / EU / EU / EU / EU / EU / EU / Europe / Europe / Europe / Europe / Europe. | |
| TH130492B (en) | 5-amino-4-hydroxy pentoyyl amide | |
| TW200606155A (en) | Mercaptoimidazoles as CCR2 receptor antagonists | |
| TH130492A (en) | 5-amino-4-hydroxy pentoyyl amide | |
| EA201290487A1 (en) | 5-AMINO-4-HYDROXYPENTOYOLAMIDES | |
| UA108744C2 (en) | 5-AMINO-4-HYDROXYPENTOILAMIDES | |
| MX2015012575A (en) | Novel acrylamide derivatives as antimalarial agents. |