TH130487B - The derivative peptides are derived from Factor VIII. - Google Patents
The derivative peptides are derived from Factor VIII.Info
- Publication number
- TH130487B TH130487B TH1101003174A TH1101003174A TH130487B TH 130487 B TH130487 B TH 130487B TH 1101003174 A TH1101003174 A TH 1101003174A TH 1101003174 A TH1101003174 A TH 1101003174A TH 130487 B TH130487 B TH 130487B
- Authority
- TH
- Thailand
- Prior art keywords
- derived
- factor viii
- peptide
- derivative peptides
- hemophilia
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 2
- 229960000301 Factor VIII Drugs 0.000 title abstract 2
- 102000001690 Factor VIII Human genes 0.000 title abstract 2
- 108010054218 Factor VIII Proteins 0.000 title abstract 2
- 102100000368 F8 Human genes 0.000 claims abstract 4
- 101700070229 F8 Proteins 0.000 claims abstract 4
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 abstract 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 abstract 1
- 210000001744 T-Lymphocytes Anatomy 0.000 abstract 1
- 102000004965 antibodies Human genes 0.000 abstract 1
- 108090001123 antibodies Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000038129 antigens Human genes 0.000 abstract 1
- 108091007172 antigens Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000003542 factor VIII deficiency Diseases 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้ให้เพปไทด์ (peptide) ที่อย่างน้อยส่วนหนึ่งสามารถอนุพัทธ์ได้มาจาก FVIII ซึ่งสามารถจับกับโมเลกุล MHC คลาส II โดยปราศจากกระบวนการแอนติเจนและถูกจดจำโดย T เซลล์ที่จำเพาะกับแฟกเตอร์ VIII โดยเฉพาะอย่างยิ่ง การประดิษฐ์นี้ให้เพปไทด์ซึ่งประกอบรวมด้วย หรือประกอบด้วยลำดับ EDNIMVTFRNQASR การประดิษฐ์นี้ยังเกี่ยวข้องกับการใช้ของเพปไทด์นั้น สำหรับการป้องกันหรือการระงับการสรางแอนติบอดีของสารยับยั้งในฮีโมฟิเลีย A และ/หรือ ฮีโมฟิเลียที่เกิดขึ้นภายหลัง The invention provided at least part of the peptide derived from FVIII, which binds to MHC class II molecules without antigen and is recognized by T cells that are specific to factor VIII. The invention provides a peptide that includes Or composed of sequences EDNIMVTFRNQASR The invention also involved the use of that peptide. For prevention or suppression of inhibitory antibody formation in hemophilia A and / or post-hemophilia.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH130487B true TH130487B (en) | 2013-12-25 |
| TH130487A TH130487A (en) | 2013-12-25 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015502180B1 (en) | Wt1-antigen peptide conjugate vaccine | |
| CY1123304T1 (en) | INHIBITING PEPTIDES DERIVED FROM TREM TRANSCRIPTION TYPE 1 (TLT-1) AND USES THEREOF | |
| RU2018132044A (en) | ANTIBODIES AGAINST TAU | |
| EA201000207A1 (en) | NEW IMMUNOGENIC EPITOPES FOR IMMUNOTHERAPY | |
| NZ731571A (en) | T cell receptors | |
| UA118167C2 (en) | Peptides and their use | |
| WO2016054598A3 (en) | Antibodies that bind ebola glycoprotein and uses thereof | |
| EA201070271A1 (en) | PEPTIDES FOR RECEIVING A VACCINE | |
| UA112416C2 (en) | FAP ANTIBODY AND METHODS OF ITS APPLICATION | |
| UA111818C2 (en) | ANTIBODY AGAINST CSF-1R | |
| EA201070681A1 (en) | PEPTIDES FVIII AND THEIR APPLICATION FOR THE INDUCTION OF TOLERANCE IN PATIENTS WITH HEMOPHILIA | |
| EA201390806A1 (en) | CONSTRUCTION OF PEPTIDE FRAME | |
| TR201903026T4 (en) | S100A4 ANTIBODIES AND THEIR THERAPEUTIC USES. | |
| WO2009052489A3 (en) | Novel inhibitors of mammalian tight junction opening | |
| EA201691306A1 (en) | PEPTIDE COMBINATIONS AND THEIR APPLICATION IN THE TREATMENT OF ALLERGY ON THE CLAW OF HOME DUST | |
| PH12015501033A1 (en) | Peptides | |
| EA201492068A1 (en) | PEPTID HYDROCHLORIDE SALT AND ITS APPLICATION IN COMBINATION WITH OTHER PEPTIDES IN IMMUNOTHERAPY | |
| EA201171430A1 (en) | Peptides | |
| AR066311A1 (en) | ANTI PROTEIN ANTIBODIES MOLECULES HSP90 FUNGICA AND NUCLEIC ACIDS CODING THEM | |
| EA201390811A1 (en) | TOMM34 PEPTIDES AND CONTAINING THEIR VACCINES | |
| GB201118201D0 (en) | Novel peptides | |
| TH130487B (en) | The derivative peptides are derived from Factor VIII. | |
| WO2008154493A3 (en) | Novel peptides that inhibit the opening of mammalian tight junctions | |
| UA114015C2 (en) | PEPTIDE | |
| TH130487A (en) | The derivative peptides are derived from Factor VIII. |