TH129241A - 1,2,4-triazolone derivatives - Google Patents
1,2,4-triazolone derivativesInfo
- Publication number
- TH129241A TH129241A TH1301001645A TH1301001645A TH129241A TH 129241 A TH129241 A TH 129241A TH 1301001645 A TH1301001645 A TH 1301001645A TH 1301001645 A TH1301001645 A TH 1301001645A TH 129241 A TH129241 A TH 129241A
- Authority
- TH
- Thailand
- Prior art keywords
- disease
- formula
- pharmacokinetics
- disorder
- cerebral
- Prior art date
Links
- MDTUWBLTRPRXBX-UHFFFAOYSA-N 1,2,4-triazol-3-one Chemical class O=C1N=CN=N1 MDTUWBLTRPRXBX-UHFFFAOYSA-N 0.000 title claims abstract 3
- 201000010099 disease Diseases 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 4
- 230000036231 pharmacokinetics Effects 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 239000011780 sodium chloride Substances 0.000 claims abstract 4
- 102100017238 AVP Human genes 0.000 claims abstract 2
- 101700084127 AVP Proteins 0.000 claims abstract 2
- 206010057666 Anxiety disease Diseases 0.000 claims abstract 2
- 206010048962 Brain oedema Diseases 0.000 claims abstract 2
- 206010008118 Cerebral infarction Diseases 0.000 claims abstract 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims abstract 2
- 208000008208 Craniocerebral Trauma Diseases 0.000 claims abstract 2
- 206010013663 Drug dependence Diseases 0.000 claims abstract 2
- 206010015037 Epilepsy Diseases 0.000 claims abstract 2
- 208000008665 Gastrointestinal Disease Diseases 0.000 claims abstract 2
- 206010019196 Head injury Diseases 0.000 claims abstract 2
- 206010020772 Hypertension Diseases 0.000 claims abstract 2
- 206010061218 Inflammation Diseases 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 201000004384 alopecia Diseases 0.000 claims abstract 2
- 231100000360 alopecia Toxicity 0.000 claims abstract 2
- 230000003042 antagnostic Effects 0.000 claims abstract 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims abstract 2
- 201000006474 brain ischemia Diseases 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 235000014632 disordered eating Nutrition 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 201000006180 eating disease Diseases 0.000 claims abstract 2
- 201000002146 gastrointestinal system disease Diseases 0.000 claims abstract 2
- 230000004054 inflammatory process Effects 0.000 claims abstract 2
- 201000008895 mood disease Diseases 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 230000004224 protection Effects 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 206010008748 Chorea Diseases 0.000 claims 1
- 201000001973 choreatic disease Diseases 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 abstract 1
- 201000001971 Huntington's disease Diseases 0.000 abstract 1
- 206010061536 Parkinson's disease Diseases 0.000 abstract 1
Abstract
DC60 (11/06/56) การประดิษฐ์นี้ จัดเตรียมอนุพันธ์ 1,2,4-ไตรแอโซโลนที่แทนด้วยสูตร (1A) ที่มีกิจกรรมเป็น ปฏิปักษ์ (antagonistic activity) ต่ออาร์จินีน-แวโซเพรซซิน 1b รีเซพเตอร์ หรือ เกลือของสารที่ยอมรับ ได้เชิงเภสัชกรรม และให้องค์ประกอบเชิงเภสัชกรรมที่ประกอบรวมด้วย สารประกอบ หรือ เกลือ เป็นส่วนผสมมีฤทธิ์ โดยเฉพาะอย่างยิ่ง สารเพื่อการรักษา หรือการป้องกัน ที่แสดงเภสัช จลนพลศาสตร์ที่ (pharmacokinetics) ที่นิยมในโรค เช่น mood disorder, anxiety disorder, schizophernia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema,head injury, inflammation, immune-related disease, หรือ alopecia [สูตร 1] สูตรเคมี (1A) สิทธิบัตรยา DC60 (11/06/56) invention of this Prepare the derivative 1,2,4-triazolone represented by formula (1A) with antagonistic activity against arginine-vasopressin 1b receptor or salt of the accept Pharmacy And the pharmaceutical components that contain compounds or salts as active ingredients Especially Therapeutic agents Or protections showing pharmacokinetics that (pharmacokinetics) popular in diseases such as mood disorder, anxiety disorder, schizophernia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia [Formula 1] chemical formula (1A) drug patent
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH129241A true TH129241A (en) | 2013-11-14 |
TH129241B TH129241B (en) | 2013-11-14 |
Family
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