TH127211B - The pyrazolo compound [1,5-a] pyrimidine was replaced as a TRK kinase inhibitor. - Google Patents
The pyrazolo compound [1,5-a] pyrimidine was replaced as a TRK kinase inhibitor.Info
- Publication number
- TH127211B TH127211B TH1201000066A TH1201000066A TH127211B TH 127211 B TH127211 B TH 127211B TH 1201000066 A TH1201000066 A TH 1201000066A TH 1201000066 A TH1201000066 A TH 1201000066A TH 127211 B TH127211 B TH 127211B
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- trk kinase
- pyrimidine
- replaced
- kinase inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 3
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 3
- 102100016102 NTRK1 Human genes 0.000 title 1
- 125000000714 pyrimidinyl group Chemical group 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910006074 SO2NH2 Inorganic materials 0.000 claims 1
- 125000004965 chloroalkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000000565 sulfonamide group Chemical group 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010029333 Neurosis Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 201000009910 diseases by infectious agent Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 201000006487 neurotic disease Diseases 0.000 abstract 1
Abstract
สารประกอบของสูตร I (สูตรเคมี) I และเกลือของสิ่งเหล่านี้ซึ่ง R1,R2,R3,R4,X,Y และ n มีความหมายตามที่ให้ไว้ในข้อกำหนด,คือ ตัวยับยั้งของ Trk ไคเนสและเป็นประโยชน์ในการรักษาของโรคซึ่งสามารถถูกรักษาด้วยตัวยับยั้ง Trk ไคเนส เช่น ความเจ็บปวด,มะเร็ง,การอักเสบ,โรคประสาทเสื่อมและบางโรคติดเชื้อ: Compounds of formula I (chemical formula) I and salts of them, which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, namely Trk kinase inhibitors and is useful in the treatment of diseases which can be treated with Trk kinase inhibitors such as pain, cancer, inflammation, neurosis and some infectious diseases:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH127211A TH127211A (en) | 2013-09-20 |
| TH127211B true TH127211B (en) | 2013-09-20 |
Family
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