TH126607B - "New elements and processes for the preparation of 5-amino or replaced amino 1,2,3-Triazole And Triacol O Rotate formula " - Google Patents
"New elements and processes for the preparation of 5-amino or replaced amino 1,2,3-Triazole And Triacol O Rotate formula "Info
- Publication number
- TH126607B TH126607B TH1201000899A TH1201000899A TH126607B TH 126607 B TH126607 B TH 126607B TH 1201000899 A TH1201000899 A TH 1201000899A TH 1201000899 A TH1201000899 A TH 1201000899A TH 126607 B TH126607 B TH 126607B
- Authority
- TH
- Thailand
- Prior art keywords
- amino
- triazole
- processes
- triacol
- preparation
- Prior art date
Links
- JSIAIROWMJGMQZ-UHFFFAOYSA-N 2H-triazol-4-amine Chemical compound NC1=CNN=N1 JSIAIROWMJGMQZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 abstract 1
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000006934 chronic myeloid leukemia Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-M orotate Chemical class [O-]C(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-M 0.000 abstract 1
- 201000011056 retinal disease Diseases 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing Effects 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Abstract
ได้เปิดเผย พอลิมอร์ฟตัวใหม่ของ 5-อะมิโน หรือ อะมิโนที่ถูกแทนที่ 1,2,3 -ไทรอะโซล และอนุพันธ์ ที่ถูกแทนที่ของสารเหล่านี้,ของโอโรเตทของคาร์บอกซีอะมิโดไทรอะโซล,ของสูตรของไทรอะโซลและกรด โอโรติกในสัดส่วน 11 ถึง 1:4 (เบส:กรด)และของกระบวนการที่ปลอดภัยขึ้นในการเตรียมสารเหล่านี้. สารประกอบนี้เป็นประโยชน์ในการควบคุมและบำบัดโรคที่รวมถึง แต่ไม่จำกัดกับมะเร็งชนิดก้อน,จุดรับภาพ เสื่อม,โรคจอตา,มะเร็งเม็ดเลือกขาวเรื้อรังชนิดไมอิลอยด์,AIDS และโรคซึ่งขึ้นกับการส่งทอดสัญญาณ ผิดปกติ. กระบวนการที่ปรับปรุงเพื่อเตรียมสูตรโอโรเตทนี้ใช้สารขั้นกลางเอไซด์เป็นสารตั้งต้นที่เสถียร, มีประสิทธิภาพ และปลอดภัยมากขึ้นในการสังเคราะห์พอลิมอร์ฟตัวใหม่ของคาร์บอกซีอะมิโดไทรอะโซล.: New polymorphs of 5-amino or substituted amino 1,2,3 -triazole and their substituted derivatives, of carboxes orotes. Ciamidotyazole, formulations of triazole and acid Orotics in the proportion 11 to 1: 4 (base: acid) and of the safer processes to prepare them. This compound is useful in the control and treatment of diseases including But not limited to cancer of the tumor, the image receiving point Alzheimer's, retinal disease, chronic myeloid leukemia, AIDS And diseases subject to abnormal signal transmission. The improved process for preparing this orotate formulation uses an intermediate azide as a stable, efficient substrate. And safer in the synthesis of new polymorphs of carboxymidotyazole:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH126607A TH126607A (en) | 2013-08-23 |
| TH126607B true TH126607B (en) | 2013-08-23 |
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