TH121706B - Stabilized amorphous form of imatinibMecylate - Google Patents
Stabilized amorphous form of imatinibMecylateInfo
- Publication number
- TH121706B TH121706B TH801002783A TH0801002783A TH121706B TH 121706 B TH121706 B TH 121706B TH 801002783 A TH801002783 A TH 801002783A TH 0801002783 A TH0801002783 A TH 0801002783A TH 121706 B TH121706 B TH 121706B
- Authority
- TH
- Thailand
- Prior art keywords
- amorphous form
- imatinibmecylate
- stabilized
- pharmaceutical
- amorphous
- Prior art date
Links
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 3
- -1 polyethylene- Polymers 0.000 claims 3
- KTUFNOKKBVMGRW-UHFFFAOYSA-N Imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 229960002411 imatinib Drugs 0.000 claims 2
- 239000004698 Polyethylene (PE) Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007962 solid dispersion Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
การประดิษฐ์เกี่ยวข้องกับรูปแบบอสัญฐานที่ถูกทำให้เสถียรของเกลือจากการเติมกรด มีเธนซัลโฟนิคของ 4-(4-เมทธิลไพเพอราซิน-1-อิลเมทธิล)-N-[4-เมทธิล-3-(4-ไพริดิน-3-อิล)-ไพริมิดิน- 2-อิลอะมิโน)-ฟีนิล]-เบนซาไมด์,องค์ประกอบทางเภสัชกรรม เช่น แคปซูลหรือยาเม็ดกลมแบน ที่มีรูปแบบนี้, การใช้ของรูปแบบดังกล่าวในวิธีการวินิจฉัยหรือ, ที่ให้ผลดี, สำหรับการบำบัดเพื่อ การรักษาของสัตว์เลือดอุ่น, โดยเฉพาะอย่างยิ่งมนุษย์, และการใช้ของสูตรด้วยาทำให้รูปแบบอสัณฐาน ของอิมาทินิบ มีซิเลทเสถียรเป็นสารตัวกลางสำหรับการเตรียมขององค์ประกอบทางเภสัชกรรม The invention involves the stabilized anniation forms of salts from the addition of acids. Methane sulphonic of 4- (4-methylpiperacin-1-ilmethyl) -N- (4-methyl-3- (4- pyridin-3-il) - pyridin Midin-2-ilamino) -phenyl] - benzamide, pharmaceutical components such as capsules or tablets. Where there is this pattern, the use of the above pattern in a diagnostic method or, that is effective, for therapy to Treatment of warm-blooded animals, especially humans, and the use of dosing regimens have stabilized the amorphous form of imatinibMecylate as an intermediate for the preparation of a pharmaceutical component.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH121706B true TH121706B (en) | 2013-02-28 |
| TH121706A TH121706A (en) | 2013-02-28 |
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