TH94735B - Quinoline and its modulator derivatives CSF-1R - Google Patents
Quinoline and its modulator derivatives CSF-1RInfo
- Publication number
- TH94735B TH94735B TH701001806A TH0701001806A TH94735B TH 94735 B TH94735 B TH 94735B TH 701001806 A TH701001806 A TH 701001806A TH 0701001806 A TH0701001806 A TH 0701001806A TH 94735 B TH94735 B TH 94735B
- Authority
- TH
- Thailand
- Prior art keywords
- csf
- chemical formula
- substance
- formula
- quinoline
- Prior art date
Links
- 102100005175 CSF1R Human genes 0.000 title abstract 2
- 101700063802 CSF1R Proteins 0.000 title 1
- 230000000051 modifying Effects 0.000 title 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 10
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 1
- 229960002897 Heparin Drugs 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- JSGZKHJWRITPII-UHFFFAOYSA-N oxoniumylideneazanide Chemical compound O[N] JSGZKHJWRITPII-UHFFFAOYSA-N 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drugs Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Abstract
การประดิษฐ์นั้นเกี่ยวข้องกับสารประกอบทางเคมีที่มีสูตร IAIB (สูตรเคมี) (IA) (สูตรเคมี) (IB) หรือเกลือของสารดังกล่าวซึ่งเป็นที่ยอมรับทางเภสัชกรรมซึ่งมีฤทธิ์ยับยั้ง CSF-1R ไคเนส และดังนั้น จึงมีประโยชน์เนื่องจากฤทธิ์ต้านมะเร็งของสารดังกล่าว และดังเช่นในวิธีการรักษาร่างกายของมนุษย์ หรือสัตว์ การประดิษฐ์นั้นเกี่ยวข้องกับกรรมวิธีสำหรับการผลิตสารประกอบทางเคมีดังกล่าว สารผสมทางเภสัชกรรมซึ่งมีสารดังกล่าว และการใช้สารดังกล่าวในการผลิตตัวยามี่มีประโยชน์ใน การทำให้เกิดผลต้านมะเร็งในสัตว์เลือดอุ่น เช่น มนุษย์อีกด้วย: The invention involves a chemical compound with the formula IAIB (Chemical formula) (IA) (Chemical formula) (IB) or a salt of such substance, which is pharmacologically acceptable, has an inhibitory effect on CSF-1R kinase and therefore has Benefit due to the anti-cancer effect of the said substance And as in human or animal body treatments, the invention involves a process for the manufacture of such chemical compounds. Pharmaceutical mixtures containing such substances And the use of such substances in drug production is useful in Also causing anticancer effects in warm-blooded animals such as humans:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH94735A TH94735A (en) | 2009-03-27 |
| TH94735B true TH94735B (en) | 2009-03-27 |
Family
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