TH11673B - Material: N-Oxide, Enanthiomer And its mixtures and used - Google Patents
Material: N-Oxide, Enanthiomer And its mixtures and usedInfo
- Publication number
- TH11673B TH11673B TH9201001275A TH9201001275A TH11673B TH 11673 B TH11673 B TH 11673B TH 9201001275 A TH9201001275 A TH 9201001275A TH 9201001275 A TH9201001275 A TH 9201001275A TH 11673 B TH11673 B TH 11673B
- Authority
- TH
- Thailand
- Prior art keywords
- tramadol
- oxide
- pain
- formula
- compounds according
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 4
- 150000001204 N-oxides Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 claims abstract 6
- 229940079593 drug Drugs 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 3
- 206010011224 Cough Diseases 0.000 claims abstract 2
- 206010012735 Diarrhoea Diseases 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 abstract 4
- 229960004380 tramadol Drugs 0.000 abstract 4
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 abstract 4
- HBXKSXMNNGHBEA-ZBFHGGJFSA-N 1-[(1r,2r)-2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]-n,n-dimethylmethanamine oxide Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)C[N+](C)(C)[O-])=C1 HBXKSXMNNGHBEA-ZBFHGGJFSA-N 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 239000008896 Opium Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229960001027 opium Drugs 0.000 abstract 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับวัสดุทรามาดอล N-ออกไซด์,อีแนนซิโอเมอร์ และสูตรผสมและประโยชน์ของมัน วัสดุทรามาดอลN-ออกไซด์และสูตรผสมของมันมีประโยชน์ในทางเป็นยาบำบัดอาการปวด, ท้องเสียและอาการไอ อีกทั้ง ทรามาดอลยังก่อให้เกิดผลข้างเคียงน้อย เมื่อเทียบกับสูตรผสมที่มีพื้นฐานเป็นฝิ่นบริสุทธิ์ เช่นที่ได้มีการใช้ทำหน้าที่ในทางที่ผิด ทำให้มีความสามารถในการทน ทำให้เกิดอาการท้องผูกและมีการกดการหายใจ นอกจากนี้เพื่อให้วัสดุทรามาดอล N-ออกไซด์ทางปากยังแสงผลในการระงับอาหารปวดได้ในระยะเวลานานกว่าเมื่อใช้ยาระงับอาการปวดที่มีปริมาณเท่ากันกับทรามาดอล สิทธิบัตรยา This invention relates to tramadol material. N-oxide, enanciomer And the formula and its benefits The tramadol N-Oxide material and its formulations are useful as a treatment for pain, diarrhea and cough, and the tramadol has few side effects. When compared with a formula based on pure opium Such as having been used to act in the wrong way Making it capable of tolerating Causing constipation and breathing pressure In addition, to provide tramadol material Oral N-Oxide was also effective in suppressing pain over a longer period of time than when used an analgesic containing the same dosage as the drug tramadol.
Claims (7)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH13252A TH13252A (en) | 1993-10-13 |
| TH11673B true TH11673B (en) | 2002-01-14 |
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