TH110875B - Process for the preparation of sucrose-6-esters By esterification in the presence of solid superacid catalysts. - Google Patents
Process for the preparation of sucrose-6-esters By esterification in the presence of solid superacid catalysts.Info
- Publication number
- TH110875B TH110875B TH701005348A TH0701005348A TH110875B TH 110875 B TH110875 B TH 110875B TH 701005348 A TH701005348 A TH 701005348A TH 0701005348 A TH0701005348 A TH 0701005348A TH 110875 B TH110875 B TH 110875B
- Authority
- TH
- Thailand
- Prior art keywords
- sucrose
- esters
- esterification
- preparation
- sucralose
- Prior art date
Links
- 239000003054 catalyst Substances 0.000 title claims abstract 3
- 239000003930 superacid Substances 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 238000005886 esterification reaction Methods 0.000 title 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract 4
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims abstract 4
- 239000005720 sucrose Substances 0.000 claims abstract 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003759 ester based solvent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000000737 periodic Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002194 synthesizing Effects 0.000 claims 1
- FYSNRJHAOHDILO-UHFFFAOYSA-N Thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 2
- BAQAVOSOZGMPRM-JVFSCRHWSA-N (2R,3R,4R,5R,6R)-2-[(2S,3R,4R,5R)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@]1(CCl)[C@H](O)[C@@H](O)[C@H](CCl)O1 BAQAVOSOZGMPRM-JVFSCRHWSA-N 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N AI2O3 Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N Sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004376 Sucralose Substances 0.000 abstract 1
- SSVFMICWXDVRQN-UHFFFAOYSA-N ethanol;sodium Chemical compound [Na].CCO SSVFMICWXDVRQN-UHFFFAOYSA-N 0.000 abstract 1
- NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 235000019408 sucralose Nutrition 0.000 abstract 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000010215 titanium dioxide Nutrition 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
Abstract
รูปลักษณะหนึ่งของการประดิษฐ์นี้ คือ กระบวนการของการเตรียมซูโครส-6-เอสเทอร์ จากซูโครสโดยทรานส์เอสเทอริฟิเคชัน ในการมีอยู่ของคะตะลิสต์ชนิดซูเปอร์แอซิดที่เป็นของแข็ง เช่น SO42---TiO2/AI2O3 หรือ SO42---Tio2 จากนั้น ซูโครส-6-อะซิเตต จะถูกคลอริเนทเพื่อให้ ซูคราโลส-6-อะซิเตต โดยใช้ BTC หรือ ไธโอนิล คลอไรด์ เปลี่ยนซูคราโลส-6-อะซิเตต ไปเป็น TPSGA สำหรับความมุ่งหมายของการทำให้บริสุทธิ์ TPSGA จะผ่านดีเอสเทอริฟิเคชันโย โซเดียม เมทธอกไซค์/เมทธานอล หรือ โซเดียม เอทธอกไซค์/เอทธานอล เพื่อให้ซูคราโลส One feature of this invention is the process of preparing sucrose-6-esters. From sucrose by trans esterification In the presence of solid superacid catalysts such as SO42 --- TiO2 / AI2O3 or SO42 --- Tio2, then sucrose-6-acetate. Will be chlorinated so that Sucralose-6-acetate, using BTC or thionyl chloride, converts sucralose-6-acetate to TPSGA.For purification purposes, TPSGA will pass DST. Arrification yosodium methoxide / methanol or sodium ethoxide / ethanol For sucralose
Claims (4)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH110875B true TH110875B (en) | 2011-11-21 |
| TH110875A TH110875A (en) | 2011-11-21 |
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