TH106943A - Benzimidazolone compounds with anti-active 5-HT4 receptor - Google Patents

Abstract

DC60 (19/11/47) The present invention provides compounds of formula (I): (chemical formula) (I) or pharmaceutically accepted salts thereof, and mixtures containing such compounds, and the use of such compounds for the manufacture of pharmaceuticals for gastroesophageal reflux disease, gastritis, motility disorders, non-ulcerative dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, indigestion, esophagitis, gastritis, nausea, central nervous system diseases, Alzheimer's disease, cognitive disorders, vomiting, migraine, neurological diseases, pain, cardiovascular disorders, heart failure, arrhythmias, diabetes and respiratory arrest syndrome. These compounds have 5-HT receptor antagonist activity and are therefore useful for the treatment of gastroesophageal reflux disease. Gastroesophageal reflux disease, non-ulcerative dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammals, especially humans. The present invention provides compounds of formula (I): (chemical formula) (I) or pharmaceutically acceptable salts thereof, and mixtures containing such compounds, and the use of such compounds for the manufacture of pharmaceuticals for gastroesophageal reflux disease, gastritis, motility disorders, non-ulcerative dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, indigestion, esophagitis, gastroesophageal disease, nausea, central nervous system diseases, Alzheimer's disease, cognitive disorders, vomiting, migraine, neurological diseases, pain, cardiovascular disorders, heart failure, arrhythmias, diabetes and respiratory arrest syndrome. These compounds have 5-HT receptor antagonist activity and are thus useful for the treatment of gastroesophageal reflux disease. Gastric and esophageal indigestion, non-ulcerative dyspepsia, functional dyspepsia, irritable bowel syndrome, or similar in mammals, particularly humans.

Claims (1)

1. Compounds of formula (I): (Chemical formula) (I) in which Het represents the heterocyclic group containing one atom of nitrogen, which B directly binds. And carbon from 4 to 7 atoms and hetero groups Such cyclic is not replaced or is substituted with a 1 to 4 substitution group independently selected from a group containing 1 (alpha) 1; A represents an L-Kylene group containing from 1 to 4 carbon atoms; B represents a covalent bond or an alkylene group with carbon from 1 to 5 atoms and six: drug patent.