TH106094A - Interaction inhibitor between MDM2 and P53. - Google Patents
Interaction inhibitor between MDM2 and P53.Info
- Publication number
- TH106094A TH106094A TH801004823A TH0801004823A TH106094A TH 106094 A TH106094 A TH 106094A TH 801004823 A TH801004823 A TH 801004823A TH 0801004823 A TH0801004823 A TH 0801004823A TH 106094 A TH106094 A TH 106094A
- Authority
- TH
- Thailand
- Prior art keywords
- mdm2
- formula
- compounds
- chemical formula
- well
- Prior art date
Links
- 102100019155 MDM2 Human genes 0.000 title claims abstract 5
- 101700032565 MDM2 Proteins 0.000 title claims abstract 5
- 239000003112 inhibitor Substances 0.000 title claims abstract 5
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 5
- 230000003993 interaction Effects 0.000 title claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- 239000000126 substance Substances 0.000 claims abstract 6
- 239000000470 constituent Substances 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
Abstract
DC60 (11/12/51) การประดิษฐ์ให้สารประกอบของสูตร (I), การใช้ของสารเหล่านั้นเป็นตัวยับยั้งอันตรกิริยา ระหว่าง p53 และ MDM2 รวมทั้งองค์ประกอบทางเภสัชกรรมที่ประกอบรวมด้วยสารประกอบ ดังกล่าว (สูตรเคมี) (I) ซึ่ง n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q และ Z มีความหมายที่นิยามไว้แล้ว การประดิษฐ์ให้สารประกอบของสูตร (I), การใช้ของสารเหล่านั้นเป็นตัวยับยั้งอันตรกิริยา ระหว่าง p53 และ MDM2 รวมทั้งองค์ประกอบทางเภสัชกรรมที่ประกอบรวมด้วยสารประกอบ ดังกล่าว: (สูตรเคมี) (I) ซึ่ง n,m,p,s,t,R1,R2,R3,R4,R5,R6,R7,R20,X,Y,Q และ Z มีความหมายที่นิยามไว้แล้ว: สิทธิบัตรยา DC60 (11/12/51) The invention provides compounds of formula (I), the use of them as inhibitors of interactions between p53 and MDM2, as well as the pharmaceutical constituents that make up the compound (chemical formula) (I. ) Where n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q and Z have already defined meanings. The invention provides compounds of formula (I), their use as an inhibitor of the interaction between p53 and MDM2, as well as the pharmaceutical components that make up such compounds: (Chemical formula) (I), where n, m, p. , s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q and Z have a predetermined meaning: drug patents.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH106094A true TH106094A (en) | 2011-02-24 |
| TH106094B TH106094B (en) | 2011-02-24 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE547415T1 (en) | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | |
| UA91027C2 (en) | Inhibitors of the interaction between mdm2 and p53 | |
| IL185275A0 (en) | N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same | |
| CY1112305T1 (en) | Formulation Containing Metformin and Vildagliptin | |
| EA200500203A1 (en) | NEW METHOD OF SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS THAT HERE CONTAINS | |
| CY1109916T1 (en) | Benzimidazolo-thiophene compounds as PLK inhibitors | |
| MX2010003060A (en) | Inhibitors of the interaction between mdm2 and p53. | |
| EA200970372A1 (en) | ALGHEIMER'S DISEASE INHIBITOR CONTAINING HETEROCYCLIC COMPOUND | |
| EA200801139A1 (en) | COMPOSITION FOR AEROSOL INHALATION | |
| TH106094A (en) | Interaction inhibitor between MDM2 and P53. | |
| TH157551A (en) | Heterocyclic inhibitors Aspartil Protease | |
| TH76504A (en) | A substituted 2-alkylquinazolinone derivative for PARP inhibitors. | |
| TH129809A (en) | Heterocyclic compounds are fused together. | |
| TH76320A (en) | Quinazolinone derivative for PARP inhibitors | |
| TH75303A (en) | Kinase inhibitor | |
| TH106094B (en) | Interaction inhibitor between MDM2 and P53. | |
| TH87788B (en) | Fixed-release drug formulas and their use | |
| TH107393A (en) | AKT inhibitors and p70 S6 kinase | |
| TH106301A (en) | Heterocyclic CETP inhibitor | |
| TH98374A (en) | Heterocyclic CETP inhibitor | |
| TH128610A (en) | Quinazoline dioxide derivative for PARP inhibitors | |
| TH106480A (en) | New types of diosmetin compounds Methods for preparing these substances And pharmaceutical components containing these substances | |
| TH94287A (en) | Heterocyclic CETP inhibitors | |
| TH87459A (en) | compound | |
| TH87788A (en) | Fixed-release drug formulas and their use |