TH103199A - Materials for eyes, ears, nose, and larynx containing macrophenilene-siloxane - Google Patents

Abstract

DC60 (25/06/51) What was revealed is a soft acrylic device material. It has a high refractive index. Increased strength The material contains macrophenylene siloxane. What was disclosed was a soft acrylic device material. High refractive index with Increased stiffness The material contains macrophenylene siloxane.

Claims (17)

1. Materials for devices of the eye, ear, nose, throat and larynx made of polymers consisting of a) monofunctional acrylate or methacrylate monomers [1], b) difunctional acrylate or methacrylate crosslinkers [2], and c) phenylene-siloxane macromers [3a] or [3b] (chemical formulas) (chemical formulas) (chemical formulas) (chemical formulas) where B=O(CH2)n,NH(CH2)n,or NCH3(CH2)n R1,R2,R3 are all = H, CH3,CH2CH3 or CH2OH X,X' are all = O(CH2)n, NH(CH2)n, NCH3(CH2)n, O(CH2)nC6H4, O(CH2CH2O)nCH2, O(CH2CH2CH2O)nCH2, O(CH2CH2 O(CH2CH2O)nCH2, or are meaningless J = (CH2)a, O(CH2CH2O)b, O or meaningless. If X and X' are meaningless, then J (formula) is meaningless. J', J" are all = (CH2)a, or meaningless. If X and X' are meaningless, then J', J" (formula) are meaningless. n = 0-12 Y = C6H5 (CH2)mH or O(CH2)mC6H5 Z,Z' are all = C(=O) or OCH2CH2C6H4 M = 0 - 12 a = 1 -12 b = 1 - 24 R4, R5, R6, R7, R8, R9 are all = (CH2)bH, CH=CH2, CH=C(CH3), CH2CH=CH, CH2CH+CHCH3, CH(CH3)2, CH2CH(CH)2, O(CH2)mC6H5, O(CH2)mC6H4(OH)C(O)C6H5, CH2CH2CH2NH2, CH2CH2CH2NHCH3, CH2CH2CH2N(CH3)2, H2CH2CH2NHCH2CH2NH2, CH2CH(CH3)CH2NHCH2CH2NH2, (CH2)aOC(O)C(R1) = CH2, (CH2)bSH, CH2CH2CH2OCH2(O)CH2, CH(CH3)NHCH2CH3, CH(CH3)N(CH3) CH2CH3, CH(CH3)N(CH2CH3)2, Cyclopentyl, Cyclohexyl, CH2CH2CN, CH2CH2CH2CN, CH2CH2CH(CH3)CN, CH2CI, CH2CH2CI, CH2CH2CH2CI, CH2CH2C6H4CH2CI CH2Si(CH3)3, CH2Si(CH2CH3)3, CH2CH2CF, CH2NCO, CH2NCH6H5, C6F5, phenyl or naphthyl, each of which may be selectively represented by C1-C12 alkyl, C1-C12 alkoxy, C1-C12 cycloalkyl, C1-C12 cycloalkoxy, NO2, OH, CH, NCO, NH2, F, Br, Cl, I or (CH2CH2O)bH, R10 = phenyl, biphenyl, diphenyl ether or naphthyl, each of which may be selectively represented by C1-C12 alkyl, C1-C12 alkoxy, C1-C12 cycloalkyl, C1-C12 cycloalkoxy, NO2, OH, CN,NCO, NH2, F, Br, Cl, I or (CH2CH2O)bH, and W = 3 -120 2. Materials for devices of the eye, ear, nose, throat and larynx from polymers according to patent I in which formula [1] B = O(CH2)n R1 = H or CH3 n =1-4 and Y = C6H5 3. Materials for devices for the eye, ear, nose, throat and vocal cords from polymers according to Patent 1 in which formula [2] R2,R3 are both = H or CH3 X,X' are both = O(CH2)n, O(CH2)n C6H4, or are meaningless J = O(CH2CH2O)b, or are meaningless if X and X' are meaningless then J (formula) is meaningless n = 0-6 and b = 1-24 4. Materials for devices for the eye, ear, nose, throat and larynx from polymers according to Patent 1 in which formulas [3a] and [3b] R2,R3 are all = H or CH3 R4, R5, R6, R7, R8, R9 are all = CH3 or CH2CH3 R8,R9 are all = CH3, phenyl or naphtyl R10 = phenyl, biphenyl, or naphtyl X,X' = O(CH2)n,O(CH2CH2O)nCH2, O(CH2CH2CH2O)nCH2, O(CH2CH2CH2CH2O)nCH2, or meaningless J' ,J" = (CH2)a a = 3 - 12 Z ,Z =C(=O) and W = 3 - 90 5. Materials for devices of the eye, ear, nose, throat and larynx from polymers according to Patent 1 where the phenylene siloxane macromer is a macromer of the formulas [4a] and [4b] as follows (chemical formulas) (chemical formulas) where R2, R3 both = H or CH3, R8, R9 both = CH3 or phenyl, J', J" = (CH2)a, a = 3, X,X' = O(CH2)n, n = 0, Z,Z' = C(=O), and W = 10 - 70. 6. Materials for devices of the eye, ear, nose, throat and larynx from polymers according to patent 31 in which the monomers of the formulation [2] are selected from groups consisting of ethylene glycol dimethacrylate ("EGDMA") and diethylene glycol dimethacrylate and 1,6-hexanediol dimethacrylate and 1,4-butanediol dimethacrylate and poly(ethylene oxide) dimethacrylate (average molecular weight in increments of 200-1000) and similar acrylates of these compounds. 7. Materials for devices of the eye, ear, nose, throat and larynx made from polymers according to Patent 1 containing 45 to 85% (weight/weight) of the formula [1] monomers. 8. Materials for devices of the eye, ear, nose, throat and larynx made from polymers according to Patent 1 containing 45 to 75% (weight/weight) of the formula [1] monomers. 9. Materials for devices of the eye, ear, nose, throat and larynx made of polymers according to Patent 1 containing 1 to 95% (weight/weight) of the formulated [3a] or [3b] monomers. 10. Materials for devices of the eye, ear, nose, throat and larynx made of polymers according to patent 9 containing 5 to 70% (weight/weight) of the formulated [3a] or [3b] monomers. 11. Materials for devices of the eye, ear, nose, throat and larynx made of polymers according to patent 9 containing 10 to 50% (weight/weight) of the formulated [3a] or [3b] monomers. 12. Materials for devices of the eye, ear, nose, throat and larynx made of polymers as per Patent 1, containing one or more components selected from a group of polymerizable ultraviolet absorbers and polymerizable blue light absorbers. 13. Materials for devices of the eye, ear, nose, throat and larynx made from polymers as per Patent 12 containing 0.1 to 5% (weight/weight) of a polymerizable ultraviolet absorber. 14. Materials for devices of the eye, ear, nose, throat and larynx made from polymers as per patent 13 containing 0.01 to 0.5% (weight/weight) of a polymerizable blue light absorber. 15. Materials for devices of the eye, ear, nose, throat and larynx made from polymers as per Patent 1, in which such materials have a dry refractive index of at least 1.47. 16. Materials for devices of the eye, ear, nose, throat and larynx made of polymers as per Patent 1, where the devices of the eye, ear, nose, throat and larynx are selected from a group consisting of intraocular lenses, contact lenses, artificial corneas, corneal rings or corneal implants, otolaryngoscopes and nasal implants. 17. An artificial intraocular lens constructed with the materials specified in claim 1.