TH102395B - Binding proteins specific to growth factors such as insulin and the use of these binding proteins. - Google Patents
Binding proteins specific to growth factors such as insulin and the use of these binding proteins.Info
- Publication number
- TH102395B TH102395B TH601006183A TH0601006183A TH102395B TH 102395 B TH102395 B TH 102395B TH 601006183 A TH601006183 A TH 601006183A TH 0601006183 A TH0601006183 A TH 0601006183A TH 102395 B TH102395 B TH 102395B
- Authority
- TH
- Thailand
- Prior art keywords
- igf
- binding proteins
- sequence
- insulin
- specific
- Prior art date
Links
- 108091007650 binding proteins Proteins 0.000 title claims abstract 6
- 102000024070 binding proteins Human genes 0.000 title claims abstract 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims 4
- 108090001061 Insulin Proteins 0.000 title claims 2
- 102000004877 Insulin Human genes 0.000 title claims 2
- 239000003102 growth factor Substances 0.000 title claims 2
- 108090000723 Insulin-like growth factor I Proteins 0.000 claims abstract 5
- 102000004218 Insulin-like growth factor I Human genes 0.000 claims abstract 5
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102100014231 IGF1 Human genes 0.000 claims 1
- 230000005591 charge neutralization Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001264 neutralization Effects 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 102400000022 Insulin-Like Growth Factor II Human genes 0.000 abstract 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 2
- 102000004965 antibodies Human genes 0.000 abstract 2
- 108090001123 antibodies Proteins 0.000 abstract 2
- 102000018358 Immunoglobulins Human genes 0.000 abstract 1
- 108060003951 Immunoglobulins Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000875 corresponding Effects 0.000 abstract 1
- 102000005614 monoclonal antibodies Human genes 0.000 abstract 1
- 108010045030 monoclonal antibodies Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Abstract
โปรตีนจับ ดังเช่น แอนติบอดีซึ่งเกี่ยวข้องโดยตรงกับ IGF-II โดยมีความไวปฏิกิริยาข้ามกับ IGF-I และการใช้แอนติบอดีดังกล่าวได้รับการบรรยาย กล่าวโดยจำเพาะเจาะจง โมโนโคลนอล แอนติบอดีของมนุษย์สายสมบูรณ์ซึ่งเกี่ยวข้องโดยตรงกับ IGF-II โดยมีความไวปฏิกิริยาข้ามกับ IGF-I ได้รับการเปิดเผย ยังได้รับการอภิปรายอีกด้วยเป็นลำดับของนิวคลีโอไทด์ซึ่งเข้ารหัส และลำดับของ กรดอะมิโนซึ่งประกอบรวมด้วยโมเลกุลของอิมมูโนโกลบูลินสายโซ่หนักและเบา กว่าโดยจำเพาะ เจาะจง ลำดับซึ่งสมนัยกับลำดับของสายโซ่หนักและเบาที่ติดกันซึ่งทอดข้ามช่วงกรอบงาน และ/หรือ ช่วงเพื่อการกำหนดหาสภาพคู่สม (CDR's) อย่างจำเพาะ จาก FRI ตลอดถึง FR4 หรือ CDR1 ตลอดถึง CDR3 Binding proteins such as antibodies, which are directly related to IGF-II, with cross-reactivity to IGF-I and the use of such antibodies are described. Specifically, a complete human monoclonal antibody, directly related to IGF-II, with cross-reactivity to IGF-I has been revealed. It has also been discussed as the sequence of nucleotides encoded and the sequence of amino acids made up of heavy and light chain immunoglobulin molecules. More specifically, a specific sequence corresponding to the sequence of adjacent heavy and light chains spanning across frameworks and / or ranges for specific determination of equations (CDR's) from FRI, through FR4 or CDR1, as well as CDR3.
Claims (3)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH102395A TH102395A (en) | 2010-06-30 |
| TH102395B true TH102395B (en) | 2010-06-30 |
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