TH100707B - The process for the preparation of products of benzimidazol thiamine amines and their derivatives. This is useful as a form III sodium / proton exchange inhibitor. - Google Patents
The process for the preparation of products of benzimidazol thiamine amines and their derivatives. This is useful as a form III sodium / proton exchange inhibitor.Info
- Publication number
- TH100707B TH100707B TH801003282A TH0801003282A TH100707B TH 100707 B TH100707 B TH 100707B TH 801003282 A TH801003282 A TH 801003282A TH 0801003282 A TH0801003282 A TH 0801003282A TH 100707 B TH100707 B TH 100707B
- Authority
- TH
- Thailand
- Prior art keywords
- useful
- preparation
- proton exchange
- benzimidazol
- thiamine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 4
- 238000002360 preparation method Methods 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 2
- 229910052708 sodium Inorganic materials 0.000 title abstract 2
- 239000011734 sodium Substances 0.000 title abstract 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 title 1
- -1 benzimidazol thiamine amines Chemical class 0.000 title 1
- 229960003495 thiamine Drugs 0.000 title 1
- 235000019157 thiamine Nutrition 0.000 title 1
- 239000011721 thiamine Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 108091006649 SLC9A3 Proteins 0.000 abstract 2
- 102000046061 Sodium-Hydrogen Exchanger 3 Human genes 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 208000008784 apnea Diseases 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Abstract
การประดิษฐ์นี้เป็นกระบวนการที่ปรับปรุงขึ้น สำหรับการเตรียมผลิตภัณฑ์ของสารยับยั้ง การแลกเปลี่ยนโซเดียม/โปรตอน ของรูปแบบย่อยที่ 3 (NHE-3) ซึ่งเป็นประโยชน์ในการรักษา ภาวะการหยุดหายใจในช่วงการนอนหลับ และความผิดปกติทางด่านการหายใจที่เกี่ยวข้องชนิดอื่นๆ การสังเคราะห์ที่ปรับปรุงขึ้นของสารยับยั้ง NHE-3 โดยเฉพาะ คือ เบนซิมิดาซอล ไธเอนิลเอมีน โดยมี การใช้ประโยชน์จากสารทดลองชนิดใหม่ต่างๆ และสารเคมีระหว่างทาง และทำให้ผลผลิตสุดท้ายมี ปริมาณและความบริสุทธิ์มากขึ้น โดยมีขั้นตอนของกระบวนการทำปฏิกิริยาหรือการสังเคราะห์ที่ น้อยลง This invention is an improved process. For the preparation of inhibitor products Sodium / proton exchange Of the third sub-pattern (NHE-3), which is useful in treatment Apnea during sleep And other related types of respiratory disorders Improved synthesis of a specific NHE-3 inhibitor, benzimidazolthienylamine, is utilized by a variety of new experimental compounds. And chemicals along the way And make the final product there More quantity and purity With less steps of the reaction or synthesis process
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH100707B true TH100707B (en) | 2010-03-26 |
| TH100707A TH100707A (en) | 2010-03-26 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009008465A (en) | 2-aminooxazolines as taar1 ligands. | |
| BRPI0813284A8 (en) | PROCESS FOR THE PREPARATION OF A COMPOUND OF FORMULA (I) AND COMPOUND | |
| NO20085385L (en) | Thiazole compounds such as cannabinoid receptor ligands and uses thereof | |
| TW200635585A (en) | Monocyclic substituted methanones | |
| MY142807A (en) | Benzimidazole derivative and use thereof. | |
| EA200900817A1 (en) | Method of producing fluorinated substituted heterocyclic compounds | |
| EA201001682A1 (en) | Derivatives of phenyl and benzodioxynyl-substituted indazols | |
| UA84462C2 (en) | Crystalline polymorphs of methanesulfonic acid addition salts of imatinib | |
| MX2011009127A (en) | Substituted nicotinamides as kcnq2/3 modulators. | |
| UA105185C2 (en) | Pyrrols | |
| MX352470B (en) | Malonic acid di-salts and a method for preparing malonyl dihalides. | |
| WO2009154754A3 (en) | Synthesis of deuterated morpholine derivatives | |
| EA201071012A1 (en) | DERIVATIVES OF AZETIDINE, METHOD OF THEIR RECOVERY AND USE OF THEM IN THERAPY | |
| MY148769A (en) | Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments | |
| PL401473A1 (en) | New, highly fluorescent heterocyclic substances and their preparation | |
| BRPI0606676A2 (en) | processes for the preparation of 4- (phenoxy-5-methyl-pyrimidin-4-yloxy) -piperidine-1-carboxylic acid derivatives and related compounds | |
| NO20082226L (en) | 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof | |
| EA200900008A1 (en) | NEW CHIRAL INTERMEDIATE PRODUCTS, METHOD OF THEIR PRODUCTION AND THEIR APPLICATION IN THE PRODUCTION OF TLTERODINE, PHESOTORODINE OR THEIR ACTIVE METABOLITES | |
| NO20073330L (en) | SULPHANYL-SUBSTITUTED PHENYL METHANONES AS GLYCIN TRANSPORTOR 1 (GLYT-1) INHIBITORS FOR TREATMENT OF NEVROLOGICAL AND NEVROPSYCIATRIC DISORDERS | |
| IL200323A0 (en) | Synthesis of glyt-1 inhibitors | |
| ATE550326T1 (en) | COMPOUNDS THAT CAN BE USED AS MODULATORS OF HDL | |
| TH100707B (en) | The process for the preparation of products of benzimidazol thiamine amines and their derivatives. This is useful as a form III sodium / proton exchange inhibitor. | |
| TH100707A (en) | ||
| MX2009007598A (en) | Enrofloxacin-hexahydrate. | |
| UA93860C2 (en) | Process for the preparation of pyrazoles, process for the regioselective alkylation and use of phosphate or phosphonate |