SU997084A1 - Method of simulating peritonitis - Google Patents

Description

The invention relates to medicine, in particular, to methods for producing models of peritonitis for the study of the rate of development, course and treatment.

There is a known method for simulating peritonitis by introducing a 30% fecal suspension into the tumor cavity tlj.

However, when using a known method, the penetration of a pathogenic irritant into the peritoneal cavity leads to shock, reaction and death of animals, and the introduction of a dog feces suspension, where the response of microflora to drugs is insufficiently investigated, makes it difficult to study yeritonitis under conditions of medication and chemotherapy.

The aim of the invention is the approximation of an artificial pathology to the clinical course of the disease in humans, adequate to the complication of appendicitis and cholecystitis ..

The goal is achieved by the fact that when modeling peritonitis by introducing a 30% suspension of feces into the abdominal cavity, the suspension of feces is administered at a dose of 1-2 ml / kg of animal weight into the thickness of the respiratory tissue.

The method is carried out as follows.

 In r v6oKHe layers of peritoneum and prebryut

tire tissue n shne-bozor st. Nok stomach animal, such as dogs, on the background of altered reactivity. pathogenic stimulus, HanpHfdep human feces suspension is administered to the body. The injected dose is. 1-2 ml per kg of animal weight. And to prevent possible perforation

10 brgalina animal wall layers.:: Cut through to the serous cover and under ,. vision control 30% suspension -: injected with a needle into the thickness of the peritoneum and

pre-breakthrough fiber.

15

 With the introduction of a pathogenic stimulus, conditions are created that are identical to the occurrence of peritonitis with which os; -; lied appendicitis and cholecystitis in humans. To prevent the development of painful shock and peritoneal sepsis, the pathogenic stimulus is not introduced into the cavity of the brain, but is localized in the prebarum tissue and the deep layers of the peritoneum in a limited part of it and does not cause intense irritation of the receptor apparatus. serous cover. When appendicitis and cholecystitis, complicating, aggravated peritonitis, inflammatory

30 process is first localized in spruce

Claims (1)

Claim A method for simulating peritonitis by introducing a 30% feces suspension into the abdominal cavity, which is so simple because in order to bring the artificial pathology closer to the clinical course of the disease in humans, adequate to complicate appendicitis and cholecystitis, the feces suspension is administered at a dose of 1-2 ml / kg of animal weight into the thickness of the parietal peritoneum and into the peritoneal fiber.