SU97366A1 - The method of obtaining 3,4-xylyl-d-ribamine - Google Patents
The method of obtaining 3,4-xylyl-d-ribamineInfo
- Publication number
- SU97366A1 SU97366A1 SU447006A SU447009A SU97366A1 SU 97366 A1 SU97366 A1 SU 97366A1 SU 447006 A SU447006 A SU 447006A SU 447009 A SU447009 A SU 447009A SU 97366 A1 SU97366 A1 SU 97366A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- ribamine
- xylyl
- calcium
- obtaining
- solution
- Prior art date
Links
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- Saccharide Compounds (AREA)
Description
Известен способ получени 3,4ксилил-й -рибамина путем конденсадии uf-рибозы с 3,4-ксилидином и восстановлени промежзточного Nглюкозкда . Однако способ этот отличаетс сложностью, особенно на стадии выделени d-рибозы.A known method for the preparation of 3,4 xylyl-y-ribamine by condensation of uf-ribose with 3,4-xylidine and reduction of intermediate N glucoside. However, this method is complicated, especially at the stage of d-ribose isolation.
Предлагаемый способ вл етс более простым и, кроме того, сокращает производственный гфоцесс получени 3,4-ксил1:л-б -рнбамина.The proposed method is simpler and, in addition, reduces the production process for the preparation of 3,4-xyl1: lb-rnbamine.
Особен1 ость предлагаемого способа заключаетс в том, что неочищенную d-рнбозу из арабоната кальци путем его эпимернзацик , выделени свободной рибановой кислоты, лактонизапии и восстановлени лактона без выделени кадмиевой соли рибановой кислоты и обработки сероводородо:.:. а неочицденную о-рибозу при конденсации с 3,4-ксиладмно.м освобождают от эпимерных соединеипй путем выделени труднораствори.0го в водноспиртовом растворе ко глекса ЗД-ксилидин-М- л-рр-бопирйнозида с сульфатом натрил.The particularity of the proposed method lies in the fact that unpurified d-rnbose from calcium arabonate by epimerbenzide, liberating free ribanoic acid, lactonisapy and reducing lactone without isolating the cadmium ribanoic acid salt and processing hydrogen sulfide:. and neo-licensed o-ribose, when condensed with 3,4-xyladm, m, is freed from epimeric compounds by isolating the hardly soluble solution in water-alcohol solution of HP-xylidine-M-l-rr-bopyrinozide with sodium sulphate.
П р и м е р. 150 г г/-арабоната каль ш раствор ют в 525 мл воды. .; ют 50 j/y пиочдина и ипгреваюг в лвтоклаве прп температуре 135 137 в течение 6 час. Эпимерный раствор в гор чем состо нии перегружают в колбу и из него отгон ют с вод ным паром пиридин, одновременно сгуща раствор до 250 мл. Затем оставишйс раствор оставл ют на холоду до следуюпхего дн .PRI me R. 150 g of g-calc-carbonate are dissolved in 525 ml of water. ; There are 50 j / y pyocdin and ipgreuyug in a 13-pin temperature of 135 137 for 6 hours. The epimeric solution, in a hot state, is transferred to a flask and pyridine is distilled off with water vapor, while condensing the solution to 250 ml. The remaining solution is then left in the cold until the next day.
Выкристаллизовавшийс избыточный арабонат кальци;- отфильтровывают и промывают небольщим количеством лед ной воды. Получают около 95 г арабоната кальци ; около 55 г превращаетс в эпимерную смесь рибоната кальци с небольши .м количеством (около 25 о) арабоната кальци .Excess calcium arabonate crystallized; - filtered and washed with a small amount of ice water. About 95 g of calcium arabonate are obtained; about 55 g is converted into an epimeric mixture of calcium ribonate with a small amount (about 25 o) of calcium arabonate.
Из полученного раст;юра кальций точно осаждают раствг/ро.ч щавелевой кислоты при иа-рСЕ ании до 85-90. Осадок оксалата кальци отфильтровывают и промывают гор чей водой. Раствор альдоновыхFrom the obtained plant; Jurassic calcium, solution / ox. of oxalic acid is precisely precipitated in the course of IR-PEC up to 85-90. The calcium oxalate precipitate is filtered off and washed with hot water. Aldonic solution
кислот осветл ют аКТГ:Б; рОВаННЫ1Acids are clarified with ACTH: B; GROUND1
углем (2 г при кип чении и затем фильтруют.charcoal (2 g at boiling and then filtered.
Светложелтый фильтрат поривают 3 вакууме до сиропа, который нагревают еще два часа на кип щейA light yellow filtrate is poured into 3 vacuum until syrup is heated for another two hours in boiling
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU447006A SU97366A1 (en) | 1952-08-04 | 1952-08-04 | The method of obtaining 3,4-xylyl-d-ribamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU447006A SU97366A1 (en) | 1952-08-04 | 1952-08-04 | The method of obtaining 3,4-xylyl-d-ribamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU97366A1 true SU97366A1 (en) | 1953-11-30 |
Family
ID=49302128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU447006A SU97366A1 (en) | 1952-08-04 | 1952-08-04 | The method of obtaining 3,4-xylyl-d-ribamine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU97366A1 (en) |
-
1952
- 1952-08-04 SU SU447006A patent/SU97366A1/en active
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