SU961698A1 - Onycholitic agent - Google Patents

Description

This invention relates to medicine, in particular to dermatology, and relates to medical preparations used in the treatment of nail plates porgiene by fungi.

Known onikholiticheskiy plaster containing urea1 nU water, lanolin and beeswax tlJ.

The effective action of a known onychotic patch appears only with long periods of its use due to its mild keratological activity.

The purpose of the invention is to increase the keratolytic effect of the patch.

This is achieved by the fact that onycholysis plaster containing urea, water, lanolin and beeswax,; additionally contains paraffin wax in the following ratio of components, wt.%;

Urea 29-, 31

Water14-16

Beeswax 9.5-10.5 Paraffin wax 9.5-10.5 LanolinOther

The plaster is prepared as follows.

The urea powder is dissolved in hot water at 80-90 ° C, where, then, at

while stirring, the form-forming base (beeswax, paraffin wax, lanolin) with all its constituents, but melted on a water bath, is added. The resulting mass is continuously stirred until thickening, and the mixture is prepared in the following ratio of components, wt.%:

ten

Urea 29-31

Water14-16

Beeswax9,5-10,5

Paraffin wax 9,5-10,5 Lanolin, Else

15 The patch was tested in the clinic, for which three of its compositions were manufactured, having different ratios of the components, which are listed in Table 1. Studies have shown that with increasing urea concentration, the keratolytic effect of the onycholytic plaster increases, and with decreasing lanolin content with increasing amount of beeswax and hard paraffin wax, its plasticity decreases. For the complete removal of all nail plates affected by fungi, 1-3 applications of the compositions are sufficient.

30 48 hours each. Composition No. 2 is the most convenient for use in combination of plastically and keratolytic properties. Comparative tests of the proposed and known onycholytic patches were carried out (control). I 14 patients with onychomycosis were under observation. The oniholytic agents studied were superimposed under the adhesive plaster on the nail plates affected by fungi on 48.4 (oniholytic plaster) and on the known plaster n 48-96 h (control then mechanical removal of softened corneous masses was performed. This cycle was repeated several times. The test results are given in Table 2 Under the action of a known plaster, the complete removal of fungal nails affected by the fungi occurred in 15-45 days.This required at least 6-8 applications for 48 hours each.Example: Ill, 46 years old, entered A diagnosis of complaints about changes in the nails of the fingers and toes, diagnosis: rubromycosis, onychomycosis of both bones and feet, confirmed by laboratory methods of research. The affected horny masses of the nail plates practically did not soften. After 1-2 times overlapping for 48 hours of the proposed onycholytic patch, the affected parts of the nail plates were removed. Using the fully. PRI m e. P 2. Ill, diagnosis: mycosis, stop, multiple onychomycosis, - due to Tr.rubrum PeniciBEium, a tennaria. A nail patch was applied to the fungus-affected nail plates. To completely remove the nail plates, at least 6 applications of 48-96 hours each were required. Fully ND records were removed only after 45 days. Example Patient, diagnosis: mycosis of the palms and feet, multiple onychomycosis due to Tg. rubru PeniciEEium, Scoputariopsis, Asper gite.us. The damaged nail plates were applied to the mushrooms by a known plaster. It took 17 days to completely remove the nail plates (6–8 applications for 48 hours each). For the complete removal of fungal-affected nail plates using the proposed onycholytic plaster, 2-3 applications were required for 48 hours each. The time for complete removal of the nail plate was 4-6 days. PRI me R 4. Sick, diagnosis: mycosis, right hand and foot, multiple onychomycosis. All affected nails are removed after. 2-3 applications of the proposed onychotic patch for 48 hours each. Example 5. Patient, diagnosis: rubromycosis of the right hand, multiple onychomycosis. All nails affected by fungi are removed after two applications of the proposed onychotic patch for 48 hours each. Three patients with onychomycosis on the part of the affected nails (8 nails) were applied the proposed onycho-lytic plaster, on the remaining nails (8 nails) a known plaster. The tests were carried out blindly. After 2-3 applications for 48 hours each of the proposed onycholysis plaster, all the nails were completely removed. After the same exposure of a known plaster, no visible effect was observed in any case. Patients continued to apply the known plaster for another 4 days: only 1/41/2 of the affected nail plates were removed. Due to the ineffectiveness of the known plaster to patients for one day, the proposed oniholytic plaster was applied, and all the nails were completely removed. Side effects in the application of the studied oniholiticheskogo funds were noted. The plastic properties of the onycholysis plaster offered in the favorable direction distinguish it from the well-known one in that it is somewhat harder, therefore it does not spread on the nail and on the periungual ridges during application. Thus, the proposed onycholytic plaster provides a keratolytic effect 5 times stronger than the known plaster and, thus, allows, respectively, to reduce the overall duration of treatment of patients and reduce the time of loss or disability.

Table

Urea

Water

Beeswax

Lanolin Paraffin Wax

In order to enhance the keratolytic effect, it additionally contains paraffin wax with the following ratio of components, wt%:

20 15 10 35 10

31 15

10.5 33

10.5

table 2

Information sources,

Ll taken into account during the examination 1. Mashkovsky MD. Medicines. M., 1977 ,, v.1, p. 445.

Claims (1)

Claim An onycholytic patch containing 35 urea, iodine, lanolin and beeswax, characterized in that, in order to enhance the keratolytic effect, it additionally contains solid paraffin in the following ratio, wt.%: Urea Water Beeswax Paraffin wax Lanolin 29-31 14-16 9.5-10.5 9.5-10.5 Else