SU943578A1 - Heparin daily dose determination method - Google Patents

Description

(54) METHOD FOR DETERMINING DAY HEPARIN DOSE

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The invention relates to medicine, in particular bone to the prevention and treatment of disease, associated with the pathological increase in the activity of the blood coagulation system of various etiologies.

The closest solution to the invention in its essence and the achieved result is the well-known method for determining the daily dose of heparin, which involves calculating this dose per patient’s body mass or per unit surface area tU. However, the well-known method does not provide the necessary accuracy of heparin dosage.

The aim of the invention is to improve the accuracy of the dosage of the drug.

This goal is achieved by the fact that in the method of determining the daily dose of heparin, the distinguishing feature is that the patient's body weight and the concentration of endogenous heparin in the patient's blood are determined, and the daily dose of heparin is calculated by the formula

.

where X is the required daily dose of heparin, ed .; A is the concentration of endogenous heparin at the time of examination in the patient’s blood, units / ml of blood;

The concentration of endogenous heparin is normal, u / ml of blood; C - body weight of the patient. The method is carried out as follows. The concentration of endogenous heparin in units of action (AU) per 1 ml of patient’s blood and body weight in kg is determined by a known method and, based on the data obtained, calculate the daily dose of heparin using the following formula

A-zzz m

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-№

xh

where X is the required daily dose of heparin, ed .;

A is the concentration of endogenous heparin at the time of examination in the patient’s blood, units / ml of blood;

B - normal endogenous heparin concentration, u / ml of blood;

Claims (1)

C - body weight of the patient. The method was tested in clinical and conditions in six patients with emergency treatment of severe liver injury with good immediate results. Example. Patient B., 44 years old, was admitted to the hospital with a diagnosis of serum hepatitis, cirrhosis of the liver. On admission, the concentration of endogenous heparin was 3.5 U / ml of blood. The body weight of the patient is 68 kg. According to the proposed formula, there is a daily dose of heparin for this patient, which is. 40,800 units, its introduction every 4 hours to 6800 units. against the background of the generally accepted complex treatment of this disease. During treatment, the concentration of endogenous heparin in the patient's blood is periodically monitored and, based on the data obtained, the daily dose of the drug administered is adjusted. 10 days after the start of treatment with the next blood examination, it is established that the concentration of heparin in it increases to 4.1 units. 1 ml, due to which the dose of anticoagulant according to the formula is reduced to 24,480 units. in days or up to 4080 units every 4 h Exodus - recovery. The proposed method for determining the daily dose of heparin is simple to perform and, in comparison with the known, allows to increase the accuracy of the individual dosage of the drug, its consumption and improve the effectiveness of the treatment. Claims The method of determining the daily dose of heparin, characterized in that, in order to improve the accuracy of the dosage of the drug, determine the patient's body weight and the concentration of endogenous heparin in his blood, and the daily dose of heparin is calculated by the formula),. A-zgsu where X is the required daily dose of heparin in units; A is the concentration of endogenous heparin at the time of examination in the patient’s blood, units / ml of blood; B - the concentration of endogenous heparin is normal in units / ml of blood: the patient's body weight. The background of information taken into account during the examination 1. S. Anichkov V. and Belenky M. L. Pharmacology textbook. L., Medgiz, 1955, p. 28-29.