SU833262A1 - Method of organism detoxification - Google Patents

Description

(54) METHOD OF DETOXICATION OF AN ORGANISM

The invention relates to medicine; and can be used to remove toxic substances from lymph. There is a known method of detoxifying the body by passing through the columns with the subsequent return to the patient P1. However, the method is accompanied by the sorption and destruction of lymphocytes in the lymph sometimes up to 25%, which further reduces the body's immune reactivity, already damaged by the underlying disease. The purpose of the invention is to prevent damage to lymphocytes and to obtain a more resistant therapeutic effect. This goal is achieved by the fact that the method of detoxification of the body is carried out by passing the lymph through the columns and then returning it to the patient, the lymph extracted from the body is centrifuged to separate the cellular elements, and the liquid lymph is passed through the sorption columns and mixed with the cellular ones before reinfusion. elements. The method is carried out as follows. The lymph obtained from the pre-drained thoracic duct is centrifuged, the lymphoplasm is separated from the cells, passed through adsorption columns, and mixed with the previously separated cells. Drainage of the thoracic duct is performed under local anesthesia on the left side of the neck. A combined transverse longitudinal supraclavicular approach is applied to the dorsal thoracic duct. The lymph duct of the thoracic duct is directed along a catheter into a sterile vial previously washed with heparin. From the intermediate tank, a centrifuge is fed to separate the formed elements from lymphoplasma. The complete separation of the form 1x elements from the plasma of the lymph occurs within 20 minutes at 1000 rpm. Uniform lymph elements are left in

the same eMijocTH, lymphoplasma is aspirated with a vacuum pump under sterile conditions into a second intermediate container and an extracorporeal perfusion is performed through a column of sorbents to remove toxic substances contained in the lymphatic spasm. Purified lymphoplasm is collected in a third container, and then mixed with previously separated lymph elements. The resulting mixture, which is a purified lymph, is returned to the patient by drip intravenous administration, for example, into the subclavian vein.

The composition of the purified lymph is presented in the table when comparing the changes in the composition of the central one during the purification of the lymph in 57 patients in a known manner and in the purification of only the plasma in patients with the proposed method.

From the table it follows that the proposed method of detoxifying the body almost does not alter the composition of leukocytes in the lymph and removes toxic metabolites to a greater extent.

Example. BolYna Ts. 32 g. Was admitted to the clinic with a diagnosis of acute gangrenous perforativegia appenvicitis, periappendicular abscess with a breakthrough into the free abdominal cavity, leukocytes, in μl Total protein, g / l Bilirubin, μmol / l Residual nitrogen,

mmol / L

Urea, mmol / l Ammonia, μmol / l Cholesterol, mmol / l Potassium, mmol / l Sodium, mmop / l Calcium, mmol / l

cast fibrious-purulent peritonitis. An hour after hospitalization, under anesthesia, the midline laparotomy, appendectomy, drainage and plugging of the abdominal cavity were performed. During the day, massive detoxification, antibacterial and anti-inflammatory therapy was carried out. However, there was no improvement. To relieve the effects of intoxication under local anesthesia, external drainage of the thoracic duct was performed. The drainage lymph flowed at a rate of 3 ml / mi at a pressure of 240 mm of water. Within 3 days, 4 liters of lymphoma were obtained, which was divided into uniform elements and lymphoplasm. The latter was cleaned through the SCT activated carbon, combined with the uniform lymph elements, and the patient was transfused with a drip system into the subclavian vein.

A complex of therapeutic measures, especially lympho sorption,. performed only with lymph plasma, brought the patient to recovery and she was discharged home in a satisfactory condition.

The proposed method allows to prevent damage to lymphocytes and to obtain a more lasting therapeutic effect.

1200

10,000 4.6

3.7 156.0 68, 0

42.5

17,8

11.5

22.0

360,0

143.0

5.7

4.0

4.1

3.5

122.0

9.8

2.6

1.9

58332626

Claims (1)

The invention claims that the lymph is centrifuged, the method of detoxifying the body by pulling lymph through a sorption flow of lymph through column columns and before reinfusing the mixture with its subsequent return of pain. with cell elements, different from those. Sources of information, that, in order to prevent damage taken into account in the examination, neither lymphocytes and obtaining a stable one. USSR author's certificate therapeutic effect, extracted from 583804, cl. A 61 M 1/02, .1974. cell elements are divided, and liquid