SU727198A1 - Acacetine producing method - Google Patents
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- SU727198A1 SU727198A1 SU772511436A SU2511436A SU727198A1 SU 727198 A1 SU727198 A1 SU 727198A1 SU 772511436 A SU772511436 A SU 772511436A SU 2511436 A SU2511436 A SU 2511436A SU 727198 A1 SU727198 A1 SU 727198A1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ АКАЦЕТИПА(54) METHOD OF OBTAINING ACACETYPE
1one
Изобретение относитс к фармацевтической промышленности в частности к получению биологически активного соединени .The invention relates to the pharmaceutical industry, in particular, to the preparation of a biologically active compound.
Известен способ получени флавоноидного гликозида-акацетина из льн пки кокандской путем экстракции сырь хлороформом с последующей экстракцией этанолом, упариванием; осадок отфильтровывают , спиртовой раствор хроматографируют на полиамидном сорбенте 1.A known method of producing flavonoid glycoside-acacetin from Kokand flax is made by extracting raw material with chloroform, followed by extraction with ethanol, by evaporation; the precipitate is filtered off, the alcohol solution is chromatographed on polyamide sorbent 1.
Однако известный способ вл етс длительным и трудоемким.However, the known method is long and laborious.
Целью изобретени вл етс расширение сырьевой базы и упрощение способа.The aim of the invention is to expand the raw material base and simplify the process.
Эта цель достигаетс тем, что по предлагаемому способу в качестве источника сырь используют листь бод ка щетинистого (Cirsium setosum willd), которые экстрагируют метанолом в аппарате Сокслета, после упаривани экстракт охлаждают и после фильтрации перекристаллизовывают и гидролизуют .This goal is achieved by using the proposed method as a source of raw materials using bored leaves of bristle (Cirsium setosum willd), which are extracted with methanol in a Soxhlet apparatus, after evaporation the extract is cooled and after filtration recrystallized and hydrolyzed.
Пример. 100 г измельченных листьев бод ка щетинистого экстрагируют метанолом в аппарате Сокслета в течение 48 ч. Извлечение упаривают до 250 мл и оставл ют в холодильнике дл кристаллизацииExample. 100 g of ground leaves of baud bristle are extracted with methanol in a Soxhlet apparatus for 48 hours. Extraction is evaporated to 250 ml and left in a refrigerator for crystallization
линарина на 3 ч. Осадок технического линарина (4,5 г) отфильтровывают, промывают 30-50 мл хлороформа, сущат и перекристаллизовывают из смеси диоксан: вода (1:1). Получают 3,12 г линарина с т.пл. 267-269°С к раствору 3,12 г линарина в смеси диоксан: вода (1:1) (300 мл) добавл ют концентрированной серной кислоты до содержани 10°/о (18 мл) и смесь кип т т с обратным холодильником в течение 5 ч, растворитель упаривают до половины объема (150 мл), о.хлаждают, выпавщий акацетин отфильтровывают, промывают водой до пейтральной реакции, сущат. Получают 1,34 г акацетина с т.пл. 261-263°С.linarin for 3 hours. The precipitate of technical linarin (4.5 g) is filtered off, washed with 30-50 ml of chloroform, dried and recrystallized from dioxane: water (1: 1). Obtain 3.12 g of linarin with so pl. 267-269 ° C. To a solution of 3.12 g of tinarin in a mixture of dioxane: water (1: 1) (300 ml) is added concentrated sulfuric acid to a content of 10 ° / o (18 ml) and the mixture is boiled under reflux in a for 5 h, the solvent is evaporated to half the volume (150 ml), the o.ch is cooled, the precipitated acacetin is filtered off, washed with water until it reaches a neutral reaction, it is dried. 1.34 g of acetacin are obtained. 261-263 ° C.
Предлагаемый способ обеспечивает расщирение сырьевой базы и упрощает технологию получени препарата.The proposed method ensures the spreading of the raw material base and simplifies the technology of the preparation of the drug.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU772511436A SU727198A1 (en) | 1977-07-26 | 1977-07-26 | Acacetine producing method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU772511436A SU727198A1 (en) | 1977-07-26 | 1977-07-26 | Acacetine producing method |
Publications (1)
Publication Number | Publication Date |
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SU727198A1 true SU727198A1 (en) | 1980-04-15 |
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ID=20719563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SU772511436A SU727198A1 (en) | 1977-07-26 | 1977-07-26 | Acacetine producing method |
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SU (1) | SU727198A1 (en) |
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1977
- 1977-07-26 SU SU772511436A patent/SU727198A1/en active
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