SU727198A1 - Acacetine producing method - Google Patents
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- SU727198A1 SU727198A1 SU772511436A SU2511436A SU727198A1 SU 727198 A1 SU727198 A1 SU 727198A1 SU 772511436 A SU772511436 A SU 772511436A SU 2511436 A SU2511436 A SU 2511436A SU 727198 A1 SU727198 A1 SU 727198A1
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- evaporation
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- acacetine
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ АКАЦЕТИПА(54) METHOD OF OBTAINING ACACETYPE
1one
Изобретение относитс к фармацевтической промышленности в частности к получению биологически активного соединени .The invention relates to the pharmaceutical industry, in particular, to the preparation of a biologically active compound.
Известен способ получени флавоноидного гликозида-акацетина из льн пки кокандской путем экстракции сырь хлороформом с последующей экстракцией этанолом, упариванием; осадок отфильтровывают , спиртовой раствор хроматографируют на полиамидном сорбенте 1.A known method of producing flavonoid glycoside-acacetin from Kokand flax is made by extracting raw material with chloroform, followed by extraction with ethanol, by evaporation; the precipitate is filtered off, the alcohol solution is chromatographed on polyamide sorbent 1.
Однако известный способ вл етс длительным и трудоемким.However, the known method is long and laborious.
Целью изобретени вл етс расширение сырьевой базы и упрощение способа.The aim of the invention is to expand the raw material base and simplify the process.
Эта цель достигаетс тем, что по предлагаемому способу в качестве источника сырь используют листь бод ка щетинистого (Cirsium setosum willd), которые экстрагируют метанолом в аппарате Сокслета, после упаривани экстракт охлаждают и после фильтрации перекристаллизовывают и гидролизуют .This goal is achieved by using the proposed method as a source of raw materials using bored leaves of bristle (Cirsium setosum willd), which are extracted with methanol in a Soxhlet apparatus, after evaporation the extract is cooled and after filtration recrystallized and hydrolyzed.
Пример. 100 г измельченных листьев бод ка щетинистого экстрагируют метанолом в аппарате Сокслета в течение 48 ч. Извлечение упаривают до 250 мл и оставл ют в холодильнике дл кристаллизацииExample. 100 g of ground leaves of baud bristle are extracted with methanol in a Soxhlet apparatus for 48 hours. Extraction is evaporated to 250 ml and left in a refrigerator for crystallization
линарина на 3 ч. Осадок технического линарина (4,5 г) отфильтровывают, промывают 30-50 мл хлороформа, сущат и перекристаллизовывают из смеси диоксан: вода (1:1). Получают 3,12 г линарина с т.пл. 267-269°С к раствору 3,12 г линарина в смеси диоксан: вода (1:1) (300 мл) добавл ют концентрированной серной кислоты до содержани 10°/о (18 мл) и смесь кип т т с обратным холодильником в течение 5 ч, растворитель упаривают до половины объема (150 мл), о.хлаждают, выпавщий акацетин отфильтровывают, промывают водой до пейтральной реакции, сущат. Получают 1,34 г акацетина с т.пл. 261-263°С.linarin for 3 hours. The precipitate of technical linarin (4.5 g) is filtered off, washed with 30-50 ml of chloroform, dried and recrystallized from dioxane: water (1: 1). Obtain 3.12 g of linarin with so pl. 267-269 ° C. To a solution of 3.12 g of tinarin in a mixture of dioxane: water (1: 1) (300 ml) is added concentrated sulfuric acid to a content of 10 ° / o (18 ml) and the mixture is boiled under reflux in a for 5 h, the solvent is evaporated to half the volume (150 ml), the o.ch is cooled, the precipitated acacetin is filtered off, washed with water until it reaches a neutral reaction, it is dried. 1.34 g of acetacin are obtained. 261-263 ° C.
Предлагаемый способ обеспечивает расщирение сырьевой базы и упрощает технологию получени препарата.The proposed method ensures the spreading of the raw material base and simplifies the technology of the preparation of the drug.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU772511436A SU727198A1 (en) | 1977-07-26 | 1977-07-26 | Acacetine producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU772511436A SU727198A1 (en) | 1977-07-26 | 1977-07-26 | Acacetine producing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU727198A1 true SU727198A1 (en) | 1980-04-15 |
Family
ID=20719563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772511436A SU727198A1 (en) | 1977-07-26 | 1977-07-26 | Acacetine producing method |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU727198A1 (en) |
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1977
- 1977-07-26 SU SU772511436A patent/SU727198A1/en active
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