SU722913A1 - Method of preparing 1/3'(1",4"-tetrahydrothiazine-1"-oxide) propyl/silatrones - Google Patents
Method of preparing 1/3'(1",4"-tetrahydrothiazine-1"-oxide) propyl/silatrones Download PDFInfo
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- SU722913A1 SU722913A1 SU782615799A SU2615799A SU722913A1 SU 722913 A1 SU722913 A1 SU 722913A1 SU 782615799 A SU782615799 A SU 782615799A SU 2615799 A SU2615799 A SU 2615799A SU 722913 A1 SU722913 A1 SU 722913A1
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- USSR - Soviet Union
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- oxide
- propyl
- silatrones
- tetrahydrothiazine
- preparing
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Description
Изобретение относитс к области кремнеорганической химии и касаетс нового способа получени неизвестных ранее (l,4 -тетрагидротиазин-1 -оксид)пропил силатр нов общей формулы: VI - CH -CHR-О - 51-(снЛ -N X / V 2/3 с. где R - Н, СНз. Наличие у полученных соединений одновременно силатранового и тиази оксидного колец позвол ет предпо ложить, что кремнеорганические тиазиноксйды могут примен тьс в самых различных област х народного хоз йства. Известно, что соединени содержащие в своем составе тиазиноксидное кольцо, обладают холиноли тической и противогрибковой активностью . Они могут быть использованы в качестве экстрагентов-комплексоо разователей дл селективного извлечени благородных металлов. Такие циклические аминосульфоксиды могут . , примен тьс как адгезивы, присадки к смазочным маслам, пестициды. В свою очередь производные силатронов интенсифицируют биосинтез белков, способствуют росту и регенерации соединительных тканей, шерсти и волос , преп тствуют развитию атеросклероза и звы желудка у животных. Известны реакции 1-(3-аминопропил )силатрана с бензоилхлоридом 1 или 2 ,3-дихлорбензо (cf) тиофен-1,1-даоксидом 2, Процесс ведут в среде бензола (3 ч), использу значительный избыток 3-аминопропилсилатрана (мол рное соотношение 1:3).Выход целевого продукта 79%. Реакци образовани гетероциклических систем на основе взаимодействи аминосилатранов с непредельными соединени ми не изучались. Целью изобретени вл етс разработка способа получени новых типов биологически активных веществ из класса силатранов, содержащих тиазин-З-оксидный фрагмент, форму .пы (I) , Это достигаетс тем, что 1-(3-аминопропил )силатран подвергают взаимодействию с дивинилсульфоксиThe invention relates to the field of organosilicon chemistry and concerns a new method of producing previously unknown (l, 4-tetrahydrothiazin-1-oxide) propyl silatols of the general formula: VI - CH-CHR-O - 51- (cn -NX / V 2/3 s where R is H, CH3. The presence of the compounds of silatrane and thiazia of the oxide rings at the same time allows us to assume that the organosilicon thiazinoxides can be used in various areas of the national economy. It is known that compounds containing a thiazinoxide ring have anticholinergic and resistive ribic activity. They can be used as complexing agents for selective extraction of noble metals. Such cyclic aminosulfoxides can be used as adhesives, lubricant additives, pesticides. In turn, silatron derivatives intensify protein biosynthesis, promote growth and regeneration connective tissue, hair and hair, prevent the development of atherosclerosis and gastric ulcers in animals. The reactions of 1- (3-aminopropyl) silatrane with benzoyl chloride 1 or 2, 3-dichlorobenzo (cf) thiophene-1,1-dioxide 2 are known. The process is carried out in benzene (3 hours) using a significant excess of 3-aminopropylsilatrane (molar ratio 1: 3). The yield of the target product is 79%. The reaction to form heterocyclic systems based on the interaction of aminosilate with unsaturated compounds has not been studied. The aim of the invention is to develop a method of obtaining new types of biologically active substances from the class of silatranes containing a thiazine-3-oxide fragment, the form of .py (I). This is achieved by reacting 1- (3-aminopropyl) silatrane with divinylsulfoxy
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782615799A SU722913A1 (en) | 1978-05-15 | 1978-05-15 | Method of preparing 1/3'(1",4"-tetrahydrothiazine-1"-oxide) propyl/silatrones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782615799A SU722913A1 (en) | 1978-05-15 | 1978-05-15 | Method of preparing 1/3'(1",4"-tetrahydrothiazine-1"-oxide) propyl/silatrones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU722913A1 true SU722913A1 (en) | 1980-03-25 |
Family
ID=20764663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782615799A SU722913A1 (en) | 1978-05-15 | 1978-05-15 | Method of preparing 1/3'(1",4"-tetrahydrothiazine-1"-oxide) propyl/silatrones |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU722913A1 (en) |
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1978
- 1978-05-15 SU SU782615799A patent/SU722913A1/en active
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