SU711037A1 - Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity - Google Patents
Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity Download PDFInfo
- Publication number
- SU711037A1 SU711037A1 SU772449114A SU2449114A SU711037A1 SU 711037 A1 SU711037 A1 SU 711037A1 SU 772449114 A SU772449114 A SU 772449114A SU 2449114 A SU2449114 A SU 2449114A SU 711037 A1 SU711037 A1 SU 711037A1
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- SU
- USSR - Soviet Union
- Prior art keywords
- pyrido
- thiadiazine
- dioxides
- antiinflammatory activity
- analgetic
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
рим в воде и этаноле при нагревании. Найдено, %: С 42,68; Н 3,67; N 21,35; C HyNgOjS. Вычислено, %: С 42,60; Н 3,60; N 21,30, ,63 (бутанолгвода:уксусна кислота - 4:1 si) .Rome in water and ethanol when heated. Found,%: C 42.68; H 3.67; N 21.35; C HyNgOjS. Calculated,%: C 42.60; H 3.60; N 21.30, 63 (butanol: aqueous acetic acid - 4: 1 si).
Исследовани биологической активности были проведены на белых машах и белых крысах линии Вистар при внутрибрюшинном введении.Studies of biological activity were carried out on white masks and white Wistar rats with intraperitoneal administration.
Дл оценки противовоспалительного действи была использована модель формалинового воспалени , дл чего в планетарный апоневроз задней лапы крысы вводили 2,5%-ный раствор формалина (0,1 мл). Величину отека задней лапы опЕюдел ли онкометрическим методом Л.С. Сал мона через 3 и 6 ч. после введени оркогенного агента. Испытуе- мые препараты вводили в дозе 50 мг/кг :(1/10 от ЛДдд) за 0,5 ч до и через 3 ч после введени формалина. Эталоном сравнени служит фенилбутазон (бутадион) в дозе 30 мг/кг.A formalin-inflammatory model was used to evaluate the anti-inflammatory effect, for which a 2.5% formalin solution (0.1 ml) was injected into the planetary aponeurosis of the hind paw of the rat. The value of the swelling of the hind paw was determined by the oncometric method LS Sal Mona 3 and 6 hours after the introduction of the orogenic agent. The tested drugs were administered at a dose of 50 mg / kg: (1/10 from LDDD) 0.5 hours before and 3 hours after the formalin was injected. The reference standard is phenylbutazone (butadione) at a dose of 30 mg / kg.
Дл оценки анальгетического действи была использована общеприн та методика гор чей пластинки (Эдди и Леймбах, 1953) . В качестве эталона дл сравнени анальгетической активности был использован амидопирин в дозе 100 мг/кг (1/3 от ДЦзо)The conventional hot plate technique was used to evaluate the analgesic effect (Eddie and Leimbach, 1953). Amidopyrine at a dose of 100 mg / kg (1/3 from DZZO) was used as a reference for comparison of analgesic activity.
Исследовани показа.ли, что испытанный препарат обладает противовоспалительной и анальгетической активностью , сопоставимой с эффектами примен емых в практике лекарственных веществ.Studies have shown that the tested drug has anti-inflammatory and analgesic activity comparable to the effects of medicinal substances used in practice.
Соединени 1 и П малотоксичны, ЛД50 500 мг/кг.Compounds 1 and P are of low toxicity, LD50 500 mg / kg.
Результаты испытаний, подтверждающие противовоспалительную и анальгетическую активность, представлены в таблице.The test results confirming the anti-inflammatory and analgesic activity are presented in the table.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU772449114A SU711037A1 (en) | 1977-02-01 | 1977-02-01 | Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU772449114A SU711037A1 (en) | 1977-02-01 | 1977-02-01 | Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SU711037A1 true SU711037A1 (en) | 1980-01-25 |
Family
ID=20694266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU772449114A SU711037A1 (en) | 1977-02-01 | 1977-02-01 | Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity |
Country Status (1)
Country | Link |
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SU (1) | SU711037A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA010308B1 (en) * | 2004-12-10 | 2008-08-29 | Ле Лаборатуар Сервье | Benzothiazine and benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them |
-
1977
- 1977-02-01 SU SU772449114A patent/SU711037A1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA010308B1 (en) * | 2004-12-10 | 2008-08-29 | Ле Лаборатуар Сервье | Benzothiazine and benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them |
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