SU711037A1 - Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity - Google Patents

Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity Download PDF

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Publication number
SU711037A1
SU711037A1 SU772449114A SU2449114A SU711037A1 SU 711037 A1 SU711037 A1 SU 711037A1 SU 772449114 A SU772449114 A SU 772449114A SU 2449114 A SU2449114 A SU 2449114A SU 711037 A1 SU711037 A1 SU 711037A1
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SU
USSR - Soviet Union
Prior art keywords
pyrido
thiadiazine
dioxides
antiinflammatory activity
analgetic
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SU772449114A
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Russian (ru)
Inventor
Светлана Константиновна Котовская
Галина Александровна Мокрушина
Исаак Яковлевич Постовский
Лариса Васильевна Корольченко
Евгений Леонидович Пидэмский
Алевтина Федоровна Голенева
Татьяна Ивановна Ковина
Original Assignee
Уральский ордена Трудового Красного Знамени политехнический институт им. С.М.Кирова
Пермский государственный университет
Всесоюзный Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений
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Application filed by Уральский ордена Трудового Красного Знамени политехнический институт им. С.М.Кирова, Пермский государственный университет, Всесоюзный Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений filed Critical Уральский ордена Трудового Красного Знамени политехнический институт им. С.М.Кирова
Priority to SU772449114A priority Critical patent/SU711037A1/en
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Publication of SU711037A1 publication Critical patent/SU711037A1/en

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Description

рим в воде и этаноле при нагревании. Найдено, %: С 42,68; Н 3,67; N 21,35; C HyNgOjS. Вычислено, %: С 42,60; Н 3,60; N 21,30, ,63 (бутанолгвода:уксусна  кислота - 4:1 si) .Rome in water and ethanol when heated. Found,%: C 42.68; H 3.67; N 21.35; C HyNgOjS. Calculated,%: C 42.60; H 3.60; N 21.30, 63 (butanol: aqueous acetic acid - 4: 1 si).

Исследовани  биологической активности были проведены на белых машах и белых крысах линии Вистар при внутрибрюшинном введении.Studies of biological activity were carried out on white masks and white Wistar rats with intraperitoneal administration.

Дл  оценки противовоспалительного действи  была использована модель формалинового воспалени , дл  чего в планетарный апоневроз задней лапы крысы вводили 2,5%-ный раствор формалина (0,1 мл). Величину отека задней лапы опЕюдел ли онкометрическим методом Л.С. Сал мона через 3 и 6 ч. после введени  оркогенного агента. Испытуе- мые препараты вводили в дозе 50 мг/кг :(1/10 от ЛДдд) за 0,5 ч до и через 3 ч после введени  формалина. Эталоном сравнени  служит фенилбутазон (бутадион) в дозе 30 мг/кг.A formalin-inflammatory model was used to evaluate the anti-inflammatory effect, for which a 2.5% formalin solution (0.1 ml) was injected into the planetary aponeurosis of the hind paw of the rat. The value of the swelling of the hind paw was determined by the oncometric method LS Sal Mona 3 and 6 hours after the introduction of the orogenic agent. The tested drugs were administered at a dose of 50 mg / kg: (1/10 from LDDD) 0.5 hours before and 3 hours after the formalin was injected. The reference standard is phenylbutazone (butadione) at a dose of 30 mg / kg.

Дл  оценки анальгетического действи  была использована общеприн та  методика гор чей пластинки (Эдди и Леймбах, 1953) . В качестве эталона дл  сравнени  анальгетической активности был использован амидопирин в дозе 100 мг/кг (1/3 от ДЦзо)The conventional hot plate technique was used to evaluate the analgesic effect (Eddie and Leimbach, 1953). Amidopyrine at a dose of 100 mg / kg (1/3 from DZZO) was used as a reference for comparison of analgesic activity.

Исследовани  показа.ли, что испытанный препарат обладает противовоспалительной и анальгетической активностью , сопоставимой с эффектами примен емых в практике лекарственных веществ.Studies have shown that the tested drug has anti-inflammatory and analgesic activity comparable to the effects of medicinal substances used in practice.

Соединени  1 и П малотоксичны, ЛД50 500 мг/кг.Compounds 1 and P are of low toxicity, LD50 500 mg / kg.

Результаты испытаний, подтверждающие противовоспалительную и анальгетическую активность, представлены в таблице.The test results confirming the anti-inflammatory and analgesic activity are presented in the table.

Claims (1)

Формула изобретенияClaim Пиридо 2,3-е -1,2,4-тиациазин-1,1циоксиды формулPyrido 2,3--1,2,4-thiaziazin-1,1cycioxides of the formulas ЦНИИПИ Заказ 8953/16 Филиал ППП ''Патент*' в сравнеии с интактными; в сравнении с эталоном.TSNIIIPI Order 8953/16 Branch of the PPP '' Patent * 'in comparison with intact ones; in comparison with the standard. Обладающие анальгетическим и противовоспалительным действием.With analgesic and anti-inflammatory effects.
SU772449114A 1977-02-01 1977-02-01 Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity SU711037A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU772449114A SU711037A1 (en) 1977-02-01 1977-02-01 Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU772449114A SU711037A1 (en) 1977-02-01 1977-02-01 Pyrido /2,3-e/-1,2,4-thiadiazine-1,1-dioxides possessing analgetic and antiinflammatory activity

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SU711037A1 true SU711037A1 (en) 1980-01-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010308B1 (en) * 2004-12-10 2008-08-29 Ле Лаборатуар Сервье Benzothiazine and benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010308B1 (en) * 2004-12-10 2008-08-29 Ле Лаборатуар Сервье Benzothiazine and benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them

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