SU685885A1

SU685885A1 - Arrangement for drying materials in ampoules

Info

Publication number: SU685885A1
Application number: SU772510208A
Authority: SU
Inventors: Эвелина Григорьевна Тутова; Роза Исааковна Фельдман; Клара Борисовна Гисина; Марлена Соломоновна Идельчик
Original assignee: Ордена Трудового Красного Знамени Институт Тепло И Массообмена Им. А.В.Лыкова Ан Белорусской Сср
Priority date: 1977-07-21
Filing date: 1977-07-21
Publication date: 1979-09-15

Description

(54) УСТРОЙСТВО ДЛЯ СУШКИ МАТЕРИАЛОВ В АМПУЛАХ(54) DEVICE FOR DRYING MATERIALS IN AMPULES

ii

Изобретение относитс к устройствам дл получени лиофилизнрованных материалов в ампулах и может быть использовано в медицинской и микробиологической отрасл х промышленности , преимущественно дл высокотермолабильных препаратов типа крови, плазмы и бактериальных суспензий.The invention relates to devices for the production of lyophilized materials in ampoules and can be used in the medical and microbiological industries, mainly for high thermolabile preparations such as blood, plasma and bacterial suspensions.

Наиболее близким к описываемому изобретению по технической сущности и достигаемому результату вл етс устройство дл сушки материалов в ампулах, состо щее из герметичной емкости, заполн емой сорбентом, и системы патрубков дл подсоединени к ампулам и вакуум-насосу 1).The closest to the described invention by its technical essence and the achieved result is a device for drying materials in ampoules, consisting of a sealed container filled with a sorbent, and a nozzle system for connecting to ampoules and a vacuum pump 1).

Недостатком известного устройства вл етс то, что в нем содержимое ампул может подвергатьс предварительному оттаиванию ри их переносе от холодильной камеры и подсоединении к патрубкам, а также при длительном последовательном подсоединении каждой ампулы к соответствующему патрубку, которое по тре-. бовани м стерильности осуществл етс над источником открытого огн , что тем самым снижает интенсивность процесса сушки.A disadvantage of the known device is that the contents of the ampoules in it can be pre-thawed when they are transferred from the refrigerating chamber and connected to the nozzles, as well as during long-term sequential connection of each ampoule to the corresponding nozzle, which is three. The use of sterility is carried out over an open flame source, thereby reducing the intensity of the drying process.

Целью изобретени вл етс интенсификаци процесса.The aim of the invention is to intensify the process.

Это достигаетс тем, что предлагаемое устройство дл сушки материалов в ампулах снабжено решеткой, смонтированной в емкости дл размещени сорбента, а патрубки дл подсоединени ампул укреплены в днище емкости под решеткой.This is achieved by the fact that the proposed device for drying materials in ampoules is equipped with a grid mounted in a container for accommodating a sorbent, and the connections for connecting ampoules are fixed in the bottom of a container under the grid.

На фиг. 1 схематично изображено устройство дл сущки материалов в ампулах, общий вид; на фиг. 2 - ампула.FIG. 1 shows schematically a device for viscous materials in ampoules, general view; in fig. 2 - ampoule.

Устройство содержит герметичную емкость 1 с патрубками 2 и 3 дл ввода и вывода сорбента , систему патрубков 4 и 5 дл подсоединени к ампулам и вакуум-насосу (на чертеже не показана) соответственно.The device contains a sealed container 1 with nozzles 2 and 3 for the input and output of the sorbent, a system of nozzles 4 and 5 for connection to the ampoules and a vacuum pump (not shown), respectively.

Герметична емкость 1 заполнена сорбентом в, дл размещени которого в емкости 1 смонтирована решетка 7.The sealed container 1 is filled with sorbent B, for which grating 7 is mounted in the vessel 1.

Патрубки 4 дл подсоединени ампул укреплены в днище емкости.Nozzles 4 for connecting ampoules are fixed in the bottom of the container.

Устройство работает следующим образом.The device works as follows.

Claims

A dispersed sorbent (for example, CaA zeolite) is poured onto the surface of the grid 7 into the preliminary sterilized container 1 through the pipe 2. The JbfcriepcHbrft sorbent is calcined at 450 ° C in a thermal oven for dehydration and sterilization before being filled into the tank 1. Then, a sealed container with a sorbent pipe 5 is connected to a vacuum pump, and under sterile conditions 4 containers 1 ampoules with a pre-frozen material are connected to the pipes 4. Then the vacuum pump is turned on and the system is brought to the operating mode (the set pressure of the medium and temperature), then the taps of the nozzles 4 are opened, and the process of dewatering the contents of the ampoules is led to the set final humidity. After reaching a certain final moisture content of the material in the ampoules, controlled by raising the vacuum or by changing the temperature (the sensor is placed in one of the ampoules), the taps of the nozzles 4 overlap, and without sealing the ampoules with the atmosphere, they are sealed. Sealing of ampoules is performed over a burner flame of any type at the place where the ampoule is pinched (Fig. 2). Consequently, vacuuming the ampoules after sealing is maintained in the system (the device is a vacuum pump) during the lyophilization process. Storing the contents of ampoules in a vacuum has a positive effect on the quality of the product. The proposed device, in comparison with the known, allows to maintain communication and bring the sorbent closer to the surface of the dehydrated material and thereby intensify the process while maintaining the sterility of the free-living material. Sealing ampoules with vacuum dods ensures long-term preservation of the quality of dry material. Claim device for drying materials in ampoules, consisting of a sealed container filled with a sorbent, and a nozzle system for connecting it to the ampoules and a vacuum pump, characterized in that, in order to intensify the process, it is provided with a grating, connections for connected ampoules are mounted on the bottom of the tank under the grill. Sources of information taken into account during the examination 1. USSR Author's Certificate No. 99271, cl. F 26 B 5/06, 1950.