SU664562A3 - Method of obtaining triazole derivatives or salts thereof - Google Patents

Method of obtaining triazole derivatives or salts thereof

Info

Publication number
SU664562A3
SU664562A3 SU772499560A SU2499560A SU664562A3 SU 664562 A3 SU664562 A3 SU 664562A3 SU 772499560 A SU772499560 A SU 772499560A SU 2499560 A SU2499560 A SU 2499560A SU 664562 A3 SU664562 A3 SU 664562A3
Authority
SU
USSR - Soviet Union
Prior art keywords
salts
triazole derivatives
obtaining
obtaining triazole
derivatives
Prior art date
Application number
SU772499560A
Other languages
Russian (ru)
Inventor
Бернхард Бернтссон Педер
Эрнульф Гаардер Ян
Рихард Люнг Бенгт
Original Assignee
Аб Хэссле (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аб Хэссле (Фирма) filed Critical Аб Хэссле (Фирма)
Application granted granted Critical
Publication of SU664562A3 publication Critical patent/SU664562A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

с обратным холодильником в течение ночи. Затем реакционную массу охлаждают , разбавл ют одинаковым по-объему количеством простого йзопропилового эфира и фильтруют. Получают кристаллы , которые нагревают в среде этанола , охлаждают, фильтруют,-промывают 5 простым изопропиловым эфиром и снова перекристаллизовывают из воды. Получают 20,4 г (70% от теоретического) гидрозслорида 3- (2, 6-дихлорбензилиденгидразино )-1,2,4-триазола с т.пл.194с.under reflux overnight. The reaction is then cooled, diluted with the same volume of izopropyl ether and filtered. Crystals are obtained, which are heated in ethanol, cooled, filtered, washed with 5 simple isopropyl ether and recrystallized from water again. 20.4 g (70% of theory) of 3- (2, 6-dichlorobenzylidene hydrazino) -1,2,4-triazole hydrosloride are obtained with mp 194s.

Аналогично примеру 1 синтезируют . соединени , приведенные в таблице.Analogously to example 1 is synthesized. compounds listed in the table.

1 /4-CH N-«H-iA1/4-CH N- “H-iA

Продолжение таблContinued tab

Claims (1)

Формула изобретени Invention Formula Способ получени  производных триазола общей формулыThe method of obtaining triazole derivatives of General formula 1one W-W-
SU772499560A 1976-07-05 1977-07-04 Method of obtaining triazole derivatives or salts thereof SU664562A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7607653A SE7607653L (en) 1976-07-05 1976-07-05 SUBSTITUTED TRIAZOLES

Publications (1)

Publication Number Publication Date
SU664562A3 true SU664562A3 (en) 1979-05-25

Family

ID=20328383

Family Applications (1)

Application Number Title Priority Date Filing Date
SU772499560A SU664562A3 (en) 1976-07-05 1977-07-04 Method of obtaining triazole derivatives or salts thereof

Country Status (16)

Country Link
JP (1) JPS535168A (en)
AT (1) AT351529B (en)
AU (1) AU2650677A (en)
BE (1) BE856356A (en)
DD (1) DD130478A5 (en)
DE (1) DE2727333A1 (en)
DK (1) DK295377A (en)
FI (1) FI772013A (en)
FR (1) FR2357549A1 (en)
HU (1) HU172956B (en)
LU (1) LU77684A1 (en)
NL (1) NL7707445A (en)
NO (1) NO772339L (en)
SE (1) SE7607653L (en)
SU (1) SU664562A3 (en)
ZA (1) ZA773470B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338453A (en) 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
GB201300435D0 (en) 2013-01-10 2013-02-27 Medical Res Council Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases

Also Published As

Publication number Publication date
BE856356A (en) 1978-01-02
LU77684A1 (en) 1978-01-31
AU2650677A (en) 1979-01-04
ZA773470B (en) 1978-04-26
DD130478A5 (en) 1978-04-05
FI772013A (en) 1978-01-06
HU172956B (en) 1979-01-28
JPS535168A (en) 1978-01-18
NO772339L (en) 1978-01-06
FR2357549A1 (en) 1978-02-03
DK295377A (en) 1978-01-06
AT351529B (en) 1979-07-25
SE7607653L (en) 1978-01-06
NL7707445A (en) 1978-01-09
ATA446877A (en) 1979-01-15
FR2357549B1 (en) 1979-07-20
DE2727333A1 (en) 1978-01-12

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