SU597685A1 - Method of obtaining sulfocationites containing naphthalene ring - Google Patents

Description

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In contrast to the well-known sulfonic cation exchanger, the structure of the elementary unit of the ion exchanger SNK ensures the mobility of the naphthalene ring, the possibility of using long-term divinyl compounds for cross-linking ensures a good permeability of the matrix. The OH group in structure causes the formation of strong additional hydrogen bonds with the sorbed ions, which naturally increases the selectivity. In the polymerization process, it is easy to obtain a sorbent with desired properties; if necessary, the swelling ratio can be varied within wide limits. The resulting sulfonic cation exchanger has the following characteristics; SOY 1.8-2.9 mg eq / g; K 2-7. The coefficient of selectivity relative to adenosine 80-15O,

The process of obtaining sulfonic cation exchanger of the CNS by the proposed method is delayed in the following.

M Q - aminomethacryl-8-naphthol b-sulfonic acid salt 2 in a mixture with a di- or polyvinyl cross-linking agent and a pacTBOpsnoT radical type initiator in a suitable solvent, for example, 50% aqueous dimethylformamide, is polymerized at 7 ~ 100 ° C for 2-5 hours. The resulting copolymer is recovered, treated with demineralized water, 0.5 N, N aOH, 1N. HC, organic solvents.

Example 2.16.46 g of the N a-salt of 2-aminomethacrylyl-8-naphthol-6-sulfonic acid, 4.19 g of ethylene methacrylamide, and 0.1 g of azo-diisobutyric acid dinitrile are dissolved in 31.0 ml of 50% dimethylformamide. The resulting clear solution is maintained at 95 ° C for 5 hours. Next, the resulting gel is removed and treated as in Example 1, Yield 94% of the theoretically calculated; SOY 2.40 mg eq / g; K 4.5; selectivity coefficient relative to adenosine 116.

Example 3. 13.7g of N a-salt of 2-aminome-

tacrylyl-8-naphthol-6-sulfonic acids, 1.11 g

hexamethylenedimethacrylamide and 0, O7 g of nitric nitrile, azo-diisobutyric acid are dissolved in 22.2 ml of 50% dimethylformamide. The resulting solution is kept at 95 ° C for 4 hours. The gel is then removed and treated as in Example 1. Yield 90% of theory; EOC 2.88 mg eq / g; K 7; selectivity relative to adenosine 15O.

Thus, the proposed SNK sorbent has an increased selectivity relative to nucleosides and their derivatives, for example, adenosine, and, besides, due to the rarefied structure of the framework, it has good sorption and desorption kinetics.

Claims (2)

1. A method of producing sulfonic cation exchangers containing a naphthalene ring, characterized in that, in order to increase the selectivity and permeability during sorption of biologically active substances, the a-salt 2 of aminomethacryl t-8 naphthol-6-sulfonic acid is copolymerized with polyvinyl compounds. Example 1. 49.4 g of the Na-salt of 2-amivomegacryl-8-naphthol- € sulfo acid, 20.7 g of hexamethylenedimethacrylamide and 0.35 g of dinitrile azodiisobutyric acid are dissolved in 106. ml of 50% dimethylformamide. The resulting clear solution is heated at 60 for 15 lin, at 80 ° C 4O min and at 90 ° C - 3 hours. The resulting gel is recovered, crushed and treated with demineralized water, then 0.5N. NaOH, washed to pH 78, treated with 1 n. NSB, washed with demineralized water to pH 6-7. Yield 06% of theoretically calculated; C OE 2.1 mg eq / g; K 2.85; coefficient of selectivity relative to adenosine 85. 5597685 2. The method according to p. 1, on tl and h ay w Hft-Sources of information, based on the fact that as a polyvinyl; compounds use ethyleneomethacryl-1. USSR author's certificate amide or hexamethylenedimethacrylamide. M 48O729, cl. C 08 J 5 / 2O, 1971.