SU596171A3 - Method of preparing ethoxycarbonyloxyethyl ester - Google Patents

Method of preparing ethoxycarbonyloxyethyl ester

Info

Publication number
SU596171A3
SU596171A3 SU752110881A SU2110881A SU596171A3 SU 596171 A3 SU596171 A3 SU 596171A3 SU 752110881 A SU752110881 A SU 752110881A SU 2110881 A SU2110881 A SU 2110881A SU 596171 A3 SU596171 A3 SU 596171A3
Authority
SU
USSR - Soviet Union
Prior art keywords
compound
formula
optical isomers
alkaline agent
preparing
Prior art date
Application number
SU752110881A
Other languages
Russian (ru)
Inventor
Аке Экстрем Бертиль
Олоф Харальд Сьеберг Берндт
Original Assignee
Астра Лекемедел Актиеболаг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астра Лекемедел Актиеболаг (Фирма) filed Critical Астра Лекемедел Актиеболаг (Фирма)
Application granted granted Critical
Publication of SU596171A3 publication Critical patent/SU596171A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/08—Modification of a carboxyl radical directly attached in position 2, e.g. esterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Claims (2)

лиэацией из смеси ацетона и петролейного эфира. Найдено,%: С 55,98; Н 5,66; N6,29; О 24,34; 57,20. Вычислено,%: С 56,10; Н 5,83; N6,23; О 24,88; ,S 7,13. 5 Продукт имеет сильное ИК поглсоцени  при 1780-1750 см вследствие наличи  f -лактама и карббнильных групп сложного эфира. Формула изобретени  Способ получени  этоксикарбонилоксиэтилового эфира бенэилпенициллина общей формулы РП ЯгСОНК-, «ЮСНОСООСаЗ% СНз или его оптических изомеров, о т ли   а ю ц и и с   тем, что соль бенэил пенициллина подвергают взаимодействию с соединением формулы XCHOCOOCiHs СНз где X - атом галогена, сульфонилоксигруппа , в среде несмеишвающегос  с водой органического растворител  в присутствии щелочного агента и полученное соединение вЕддел ют или при необходимости перевод т в оптические изомеры . by lietation from a mixture of acetone and petroleum ether. Found,%: C 55.98; H 5.66; N6.29; O 24.34; 57.20. Calculated,%: C 56.10; H 5.83; N6.23; O 24.88; S 7.13. 5 The product has a strong infrared intensity at 1780-1750 cm due to the presence of f-lactam and carbonyl ester groups. The method of the invention The method of obtaining ethoxycarbonyloxyethyl ester of benylpenicillin of the general formula YcCeCONC-, YUSHOSOOSA3% CH3 or its optical isomers, with the compound of the formula XCHOCOCoc having the salt of the benelyl penicillin, is reacted with a compound of the formula XCHOCOCocCocCocCocCocCocCocCocCoccocCocCocCoCoCoCoCeOcCoCoCoCoCoCoCoCoCoCoCoCoCoCoCoCoC3C3C. a sulfonyloxy group, in an environment of a water-immiscible organic solvent in the presence of an alkaline agent, and the resulting compound is added or, if necessary, converted into optical isomers. 2. Способ по п. 1, отличающийс  тем, что в качестве щелочного агента используют бикарбонат . Источники информации, прин тые вй внимание при экспертизе: 1. Патент ГДР I 70093,кл. 12р,4/01 05.12.1966.2. A method according to claim 1, characterized in that bicarbonate is used as the alkaline agent. Sources of information taken into consideration during the examination: 1. GDR patent I 70093, cl. 12p, 4/01 12/5/1966.
SU752110881A 1970-09-17 1975-03-04 Method of preparing ethoxycarbonyloxyethyl ester SU596171A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7012688A SE374747B (en) 1970-09-17 1970-09-17

Publications (1)

Publication Number Publication Date
SU596171A3 true SU596171A3 (en) 1978-02-28

Family

ID=20296148

Family Applications (1)

Application Number Title Priority Date Filing Date
SU752110881A SU596171A3 (en) 1970-09-17 1975-03-04 Method of preparing ethoxycarbonyloxyethyl ester

Country Status (5)

Country Link
AU (1) AU461353B2 (en)
CS (1) CS187317B2 (en)
SE (1) SE374747B (en)
SU (1) SU596171A3 (en)
ZA (1) ZA715836B (en)

Also Published As

Publication number Publication date
AU461353B2 (en) 1975-05-22
AU3354971A (en) 1973-03-22
CS187317B2 (en) 1979-01-31
SE374747B (en) 1975-03-17
ZA715836B (en) 1972-05-31

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