SU593425A1 - Chalcone derivatives as antibacterial substances - Google Patents

Chalcone derivatives as antibacterial substances Download PDF

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Publication number
SU593425A1
SU593425A1 SU762356309A SU2356309A SU593425A1 SU 593425 A1 SU593425 A1 SU 593425A1 SU 762356309 A SU762356309 A SU 762356309A SU 2356309 A SU2356309 A SU 2356309A SU 593425 A1 SU593425 A1 SU 593425A1
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USSR - Soviet Union
Prior art keywords
antibacterial substances
chalcone derivatives
chalcones
acute toxicity
und
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SU762356309A
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Russian (ru)
Inventor
Э.Т. Оганесян
В.С. Череватый
В.И. Яковенко
Л.П Кирильчук
Original Assignee
Oganesyan E T
Cherevatyj V S
Yakovenko V I
Kirilchuk L P
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Application filed by Oganesyan E T, Cherevatyj V S, Yakovenko V I, Kirilchuk L P filed Critical Oganesyan E T
Priority to SU762356309A priority Critical patent/SU593425A1/en
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Publication of SU593425A1 publication Critical patent/SU593425A1/en

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(54) ПРОИЗВОДНЫЕ ХАЛКОНД В КАЧЕСТВЕ АНТИБАКТЕРИАЛЬНЫХ СРЕДСТВ(54) HALCOND DERIVATIVES AS ANTIBACTERIAL MEANS

а затем выливают в подкисленную воду. Образуетс  осадок желтого цвета. Выход 75%.and then poured into acidified water. A yellow precipitate forms. 75% yield.

Найдено, %: С 36,33; Н 1,99; Вг 48,97.Found,%: C 36.33; H 1.99; Br 48.97.

CisH9Br3O4.CisH9Br3O4.

Вычислено, %: С 36,54; Н 1,84; Вг 48,62. Т. пл. 116-1,17° С (ЮН).Calculated,%: C, 36.54; H 1.84; Br 48.62. T. pl. 116-1.17 ° C. (YUN).

ИК-спектр: 1630, 1600, 1480 CM-I.IR spectrum: 1630, 1600, 1480 CM-I.

Микробиологические испытани  показывают , что полученные халконы обладают высоким антибактериальным действием на модели различных стафилококков. Бумажные диски, содержащие равные навески (в мкг) халконов и антибиотиков (пенициллина , стрептомицина, неомицина), дают в экспериментах равные зоны задержки роста стафилококка 209-Р и золотистого гемолитического стафилококка, выделенного от больного. Указанные халконы не оказывают губительного действи  на кишечную микрофлору.Microbiological tests show that the obtained chalcones have a high antibacterial effect on models of various staphylococci. Paper disks containing equal weights (in mcg) of chalcones and antibiotics (penicillin, streptomycin, neomycin) give in experiments equal zones of growth inhibition of staphylococcus 209-P and golden hemolytic staphylococcus isolated from the patient. These chalcones do not have a detrimental effect on the intestinal microflora.

Остра  токсичность у1казанных халконов определ етс  на трех видах лабораторных животных: л гушках, белых мышах и белых крысах. Вводились препараты per OS и подкожно в виде водной суспензии или раствора в диметилсульфоксиде. Контрольна  сери  опытов позвол ет изучить вли ние тех же количеств диметилсульфоксида и тех же путей введени , какие берутс  при использовании его как растворител  халконов. При испытании остройThe acute toxicity of these chalcones is determined by three types of laboratory animals: animals, white mice and white rats. Drugs were administered per OS and subcutaneously in the form of an aqueous suspension or solution in dimethyl sulfoxide. A control series of experiments allows to study the effect of the same amounts of dimethyl sulfoxide and the same routes of administration that are taken when using it as a chalcone solvent. When experiencing acute

токсичности 2,2,4-триокси-5-бромх1алкона набелых мышах при подкожном введении LDso 200 мг/кг, LjDioo 280 мг/кг. Острую токсичность 2,2,4-триокси-5-бромхалкона такжепровер ют на белых крысах. При подкожном введении 2,(2,4-триокси-3,5,5-трибромхалкона остра  токсичность LDso 60 мг/кг,, LDioo 100 мг/кг.toxicity of 2,2,4-trioxy-5-bromochondone on mice with subcutaneous administration of LDso 200 mg / kg, LjDioo 280 mg / kg. The acute toxicity of 2,2,4-trioxy-5-bromchalcone was also tested on white rats. When subcutaneously administered 2, (2,4-trioxy-3,5,5-tribromhalkona acute toxicity LDso 60 mg / kg, LDioo 100 mg / kg.

При введении 2 г/кг указанных халконов per OS смертельных исходов не наблюдалось . В сери х с определением хронической, токсичности летальности не было.With the introduction of 2 g / kg of these chalcones per OS, no deaths were observed. In the series with the definition of chronic toxicity, lethality was not.

Claims (1)

1. S. Н. Dandegaonker und G. R. Revan30 kar. Die antibacterielle Wirkung halogensubstituierter Chalkone., Arch. Pharmaz und:; Ber. Dtsch. pharmar. Ges., ,1967, 300 11, 897,1. S. N. Dandegaonker und G. R. Revan30 kar. Die antibacterielle Wirkung halogensubstituierter Chalkone., Arch. Pharmaz und :; Ber. Dtsch. pharmar. Ges.,, 1967, 300 11, 897,
SU762356309A 1976-05-11 1976-05-11 Chalcone derivatives as antibacterial substances SU593425A1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208353A (en) * 1989-06-14 1993-05-04 Smithkline Beecham Corp. Intermediates for preparing epoxy esters
KR101526055B1 (en) * 2013-07-15 2015-06-04 계명대학교 산학협력단 New chalcone compound or pharmaceutically acceptable salt thereof having inhibitory activity on Hsp90 and medical use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208353A (en) * 1989-06-14 1993-05-04 Smithkline Beecham Corp. Intermediates for preparing epoxy esters
KR101526055B1 (en) * 2013-07-15 2015-06-04 계명대학교 산학협력단 New chalcone compound or pharmaceutically acceptable salt thereof having inhibitory activity on Hsp90 and medical use thereof

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